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Rnls
Gene Detail
 Symbol
Name
ID
Rnls
renalase, FAD-dependent amine oxidase
MGI:1915045
Synonyms 6530404N21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
29.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:33137747-33392265 bp, - strand
From VEGA annotation of GRCm38

  254519 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41254  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rnls

Human
homologs
Human Homolog RNLS, renalase, FAD-dependent amine oxidase
NCBI Gene ID 55328
neXtProt AC  NX_Q5VYX0
Human Synonyms  C10orf59, RENALASE
Human Chr (Location)  10q23.31; chr10:88273864-88583854 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline.
 
Interactions
Rnls interacts with 64 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cardiac left ventricle morphogenesis, dopamine metabolic process, ...
Component extracellular region, extracellular space
Function oxidoreductase activity
External Resources: FuncBase
Expression
cDNA source data(11)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033116 (Evidence)
Ensembl Gene ModelENSMUSG00000071573 (Evidence)
Entrez Gene67795 (Evidence)
UniGene204591
DFCITC1584897
DoTSDT.50316099
EC1.6.3.5
Consensus CDS ProjectCCDS50415.1, CCDS50416.1
International Mouse Knockout Project StatusRnls
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033116 VEGA Gene Model | MGI Sequence Detail 254519 C57BL/6J ±  kb
transcript OTTMUST00000082781 VEGA | MGI Sequence Detail 1597 Not Applicable 
polypeptide OTTMUSP00000044412 VEGA | MGI Sequence Detail 300 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(1527 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002937 Amine oxidase
Protein Ontology PR:000031216 renalase
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200928 Sizova D, et al., Renalase regulates renal dopamine and phosphate metabolism. Am J Physiol Renal Physiol. 2013 Sep;305(6):F839-44
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory