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Rnls Gene Detail
Summary
  • Symbol
    Rnls
  • Name
    renalase, FAD-dependent amine oxidase
  • Synonyms
    6530404N21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915045
    NCBI Gene: 67795
  • Gene Overview
    MyGene.info: RNLS
Location & Maps
more
  • Sequence Map
    Chr19:33137747-33392265 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      254519 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 29.08 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RNLS, renalase, FAD dependent amine oxidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RNLS, renalase, FAD dependent amine oxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C10orf59, RENALASE
  • Links
    NCBI Gene ID: 55328
    neXtProt AC: NX_Q5VYX0

  • Chr Location
    10q23.31; chr10:88180643-88583854 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41254
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RNLS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    6
  • Targeted
    4
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit aggravated ischemic myocardial damage, increased heart rate, increased blood pressure and increased serum levels of dopamine, adrenaline and noradrenaline.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase rnls
    ZFIN rnls
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033116 VEGA Gene Model | MGI Sequence Detail 254519 C57BL/6J ±  kb
transcript OTTMUST00000082781 VEGA | MGI Sequence Detail 1597 Not Applicable  
polypeptide OTTMUSP00000044412 VEGA | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1512 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232785 Hollander L, et al., Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Res. 2016 Jul 1;76(13):3884-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory