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N6amt1
Gene Detail
 Symbol
Name
ID
N6amt1
N-6 adenine-specific DNA methyltransferase 1 (putative)
MGI:1915018
Synonyms 5830445C04Rik, Hemk2, Pred28
Feature Type protein coding gene
Genetic Map
Chromosome 16
49.52 cM, cytoband C3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:87354185-87368742 bp, + strand
From VEGA annotation of GRCm38

  14558 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5637  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: N6amt1

Human
homologs
Human Homolog N6AMT1, N-6 adenine-specific DNA methyltransferase 1 (putative)
NCBI Gene ID 29104
neXtProt AC  NX_Q9Y5N5
Human Synonyms  C21orf127, HEMK2, m.HsaHemK2P, MTQ2, N6AMT
Human Chr (Location)  21q21.3; chr21:28872191-28885373 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Genomic Mutations involving N6amt1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele fail to form a primitive streak and die between E7.5 and E9.5.
 
Interactions
N6amt1 interacts with 249 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process methylation, positive regulation of cell growth, ...
Component protein complex
Function methyltransferase activity, protein methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (66)    Tissues (65)    Images (3)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 48
RT-PCR 18
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026535 (Evidence)
Ensembl Gene ModelENSMUSG00000044442 (Evidence)
Entrez Gene67768 (Evidence)
UniGene296532
DFCITC1582694, TC1589859, TC1655073, TC1679335
DoTSDT.101371980, DT.55113855, DT.97388269
NIA Mouse Gene IndexU017332
Consensus CDS ProjectCCDS28289.1, CCDS49889.1
International Mouse Knockout Project StatusN6amt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026535 VEGA Gene Model | MGI Sequence Detail 14558 C57BL/6J ±  kb
transcript OTTMUST00000065657 VEGA | MGI Sequence Detail 1884 Not Applicable 
polypeptide OTTMUSP00000032752 VEGA | MGI Sequence Detail 214 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002052 DNA methylase, N-6 adenine-specific, conserved site
InterPro IPR004557 Eukaryotic/archaeal PrmC-related
Protein Ontology PR:000010942 HemK methyltransferase family member 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory