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N6amt1 Gene Detail
Summary
  • Symbol
    N6amt1
  • Name
    N-6 adenine-specific DNA methyltransferase 1 (putative)
  • Synonyms
    5830445C04Rik, Hemk2, Pred28
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915018
    NCBI Gene: 67768
Location & Maps
more
  • Sequence Map
    Chr16:87354185-87368742 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14558 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    N6AMT1, N-6 adenine-specific DNA methyltransferase 1 (putative)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    N6AMT1, N-6 adenine-specific DNA methyltransferase 1 (putative)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C21orf127, HEMK2, m.HsaHemK2P, MTQ2, N6AMT, PRED28
  • Links
    NCBI Gene ID: 29104
    neXtProt AC: NX_Q9Y5N5

  • Chr Location
    21q21.3; chr21:28872191-28885373 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5637
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: N6AMT1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving N6amt1
  • Incidental Mutations
Mice homozygous for a knock-out allele fail to form a primitive streak and die between E7.5 and E9.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026535 VEGA Gene Model | MGI Sequence Detail 14558 C57BL/6J ±  kb
transcript OTTMUST00000065657 VEGA | MGI Sequence Detail 1884 Not Applicable  
polypeptide OTTMUSP00000032752 VEGA | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 137
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR002052 DNA methylase, N-6 adenine-specific, conserved site
    IPR004557 Eukaryotic/archaeal PrmC-related
    IPR007848 Methyltransferase small domain
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
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  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 6
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory