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Ppid Gene Detail
Summary
  • Symbol
    Ppid
  • Name
    peptidylprolyl isomerase D (cyclophilin D)
  • Synonyms
    4930564J03Rik, cyclophilin 40, CYP-40, cytoplasmic cyclophilin D, Ppidl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914988
    NCBI Gene: 67738
  • Gene Overview
    MyGene.info: PPID
Location & Maps
more
  • Sequence Map
    Chr3:79591342-79603650 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12309 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 34.91 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
  • Vertebrate Orthologs
    12
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYP-40, CYPD
  • Links
    NCBI Gene ID: 5481
    neXtProt AC: NX_Q08752

  • Chr Location
    4q31.3; chr4:158709127-158723400 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31283
    1 human;1 mouse;2 rat;1 chimpanzee;2 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PPID
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ppid
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029417 VEGA Gene Model | MGI Sequence Detail 12309 C57BL/6J ±  kb
transcript OTTMUST00000072900 VEGA | MGI Sequence Detail 1752 Not Applicable  
polypeptide OTTMUSP00000037639 VEGA | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    122 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013078 eukaryotic-type peptidyl-prolyl cis-trans isomerase D
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR023114 Elongated TPR repeat-containing domain
    IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35888, MGI:107419
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:34612 Yokoi H, et al., The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. Genomics. 1996 Aug 1;35(3):448-55
  • Latest
    J:183839 Whelan RS, et al., Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6566-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory