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Ppid Gene Detail
Summary
  • Symbol
    Ppid
  • Name
    peptidylprolyl isomerase D (cyclophilin D)
  • Synonyms
    4930564J03Rik, cyclophilin 40, CYP-40, cytoplasmic cyclophilin D, Ppidl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914988
    NCBI Gene: 67738
  • Gene Overview
    MyGene.info: PPID
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79591389-79603650 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 34.91 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914988
protein coding gene Chr3:79591342-79603650 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027313
protein coding gene Chr3:79298366-79310648 (+)
A/J MGP_AJ_G0027275
protein coding gene Chr3:76706461-76718763 (+)
AKR/J MGP_AKRJ_G0027243
protein coding gene Chr3:78474481-78486829 (+)
BALB/cJ MGP_BALBcJ_G0027286
protein coding gene Chr3:76735082-76747791 (+)
C3H/HeJ MGP_C3HHeJ_G0027030
protein coding gene Chr3:78802795-78816122 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027732
protein coding gene Chr3:82313663-82327213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025085
protein coding gene Chr3:72346055-72358631 (+)
CAST/EiJ MGP_CASTEiJ_G0026477
protein coding gene Chr3:78867296-78879643 (+)
CBA/J MGP_CBAJ_G0027005
protein coding gene Chr3:85040394-85055518 (+)
DBA/2J MGP_DBA2J_G0027141
protein coding gene Chr3:76261188-76273583 (+)
FVB/NJ MGP_FVBNJ_G0027109
protein coding gene Chr3:74603022-74615356 (+)
LP/J MGP_LPJ_G0027249
protein coding gene Chr3:80267875-80280165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027128
protein coding gene Chr3:91292511-91305980 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027790
protein coding gene Chr3:78311978-78324331 (+)
PWK/PhJ MGP_PWKPhJ_G0026211
protein coding gene Chr3:76019702-76032818 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026027
protein coding gene Chr3:77452383-77469974 (+)
WSB/EiJ MGP_WSBEiJ_G0026555
protein coding gene Chr3:78636830-78649132 (+)



Homology
more
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
  • Vertebrate Orthologs
    12
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYP-40, CYPD
  • Links
    NCBI Gene ID: 5481
    neXtProt AC: NX_Q08752
    UniProt: Q08752

  • Chr Location
    4q32.1; chr4:158709127-158723400 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31283
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;2 macaque, rhesus
  • HCOP
    human homology predictions: PPID
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67738 NCBI Gene Model | MGI Sequence Detail 12262 C57BL/6J ±  kb
transcript NM_001356326 RefSeq | MGI Sequence Detail 2047 C57BL/6  
polypeptide Q9CR16 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013078 eukaryotic-type peptidyl-prolyl cis-trans isomerase D
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35888, MGI:107419
References
more
  • Summaries
    All 63
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:34612 Yokoi H, et al., The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. Genomics. 1996 Aug 1;35(3):448-55
  • Latest
    J:234299 Zhu X, et al., Cyclophilin D regulates necrosis, but not apoptosis, of murine eosinophils. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G609-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory