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Fbxo32
Gene Detail
Symbol

Name
ID
Fbxo32
F-box protein 32
MGI:1914981
Synonyms
4833442G10Rik, atrogin-1, ATROGIN1, MAFbx
Feature Type
protein coding gene
Genetic Map
Chromosome 15
24.43 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:58175879-58214892 bp, - strand
From NCBI annotation of GRCm38

  39014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBXO32
Gene Tree: Fbxo32

Human
homologs
FBXO32, F-box protein 32
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 114907
neXtProt AC: NX_Q969P5

Human Synonyms: Fbx32, MAFbx

Human Chr (Location): 8q24.13; chr8:123497887-123541253 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Fbxo32 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.
 
Phenotype Images(2)
Interactions
Fbxo32 interacts with 439 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cellular response to dexamethasone stimulus, muscle atrophy, ...
Component cytoplasm, nucleolus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (79)    Tissues (24)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
RT-PCR 4
cDNA source data(54)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fbxo32 ; ZFIN fbxo32    NEW 
Molecular
reagents
All nucleic(57) cDNA(54) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022358 (Evidence)
Entrez Gene 67731 (Evidence)
UniGene 25683
DFCI TC1579220
DoTS DT.87072192, DT.529328
NIA Mouse Gene Index U036197, U220982
Consensus CDS Project CCDS27491.1
International Mouse Phenotyping Consortium Status Fbxo32
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 67731 NCBI Gene Model | MGI Sequence Detail 39014 C57BL/6J ±  kb
transcript NM_026346 RefSeq | MGI Sequence Detail 6936 C57BL/6 
polypeptide Q9CPU7 UniProt | EBI | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
Protein Ontology PR:000007402 F-box only protein 32
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212931 Zaglia T, et al., Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. J Clin Invest. 2014 Jun 2;124(6):2410-24
All references(55)
Other
accession IDs
MGI:2146006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory