About   Help   FAQ
Fbxo32
Gene Detail
Symbol

Name
ID
Fbxo32
F-box protein 32
MGI:1914981
Synonyms
4833442G10Rik, atrogin-1, ATROGIN1, MAFbx
Feature Type
protein coding gene
Genetic Map
Chromosome 15
24.43 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:58175879-58214892 bp, - strand
From NCBI annotation of GRCm38

  39014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12182  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Fbxo32

Human
homologs
Human Homolog FBXO32, F-box protein 32
NCBI Gene ID 114907
neXtProt AC  NX_Q969P5
Human Synonyms  Fbx32, MAFbx
Human Chr (Location)  8q24.13; chr8:123497887-123541253 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Fbxo32 (1)
Incidental mutations (data from Mutagenetix , APF )
 
A targeted homozygous mutation in this gene results in resistance to skeletal muscle atrophy in response to nerve injury.
 
Interactions
Fbxo32 interacts with 440 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cellular response to dexamethasone stimulus, muscle atrophy, ...
Component cytoplasm, nucleolus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (79)    Tissues (24)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 75
RT-PCR 4
cDNA source data(54)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) cDNA(54) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022358 (Evidence)
Entrez Gene67731 (Evidence)
UniGene25683
DFCITC1579220
DoTSDT.529328, DT.87072192
NIA Mouse Gene IndexU036197, U220982
Consensus CDS ProjectCCDS27491.1
International Mouse Knockout Project StatusFbxo32
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 67731 NCBI Gene Model | MGI Sequence Detail 39014 C57BL/6J ±  kb
transcript NM_026346 RefSeq | MGI Sequence Detail 6936 C57BL/6 
polypeptide Q9CPU7 UniProt | EBI | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(223 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
Protein Ontology PR:000007402 F-box only protein 32
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203690 Martinez-Lopez N, et al., Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
All references(54)
Other
accession IDs
MGI:2146006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory