Stx17 MGI Mouse Gene Detail - MGI:1914977

Symbol

Stx17
Name

syntaxin 17
Synonyms

4833418L03Rik, 6330411F21Rik, 9030425C21Rik

Feature Type

protein coding gene
IDs

MGI:1914977
NCBI Gene: 67727
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:48124915-48186507 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 26.07 cM
Mapping Data

2 experiments

SNPs within 2kb

1333 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914977	protein coding gene	Chr4:48124912-48186507 (+)
129S1/SvImJ	ENSMUSG00200002792	protein coding gene	Chr4:44194633-44256470 (+)
A/J	ENSMUSG00195006314	protein coding gene	Chr4:44620015-44681606 (+)
AKR/J	ENSMUSG00220002272	protein coding gene	Chr4:44343048-44403315 (+)
BALB/cJ	ENSMUSG00180028054	protein coding gene	Chr4:44206632-44268227 (+)
C3H/HeJ	ENSMUSG00175019771	protein coding gene	Chr4:44355934-44417531 (+)
C57BL/6NJ	ENSMUSG00215018917	protein coding gene	Chr4:44153646-44215236 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026000	protein coding gene	Chr4:42160648-42215785 (+)
CAST/EiJ	ENSTCUG00005037300	protein coding gene	Chr4:44400944-44461180 (+)
CBA/J	ENSMUSG00210019320	protein coding gene	Chr4:44055546-44117142 (+)
DBA/2J	ENSMUSG00185031882	protein coding gene	Chr4:44419066-44480661 (+)
FVB/NJ	ENSMUSG00205015979	protein coding gene	Chr4:43715893-43777497 (+)
JF1/MsJ	ENSUMUG00000017940	protein coding gene	Chr4:44644750-44705012 (+)
LP/J	ENSMUSG00230038743	protein coding gene	Chr4:47989702-48051541 (+)
NOD/ShiLtJ	ENSMUSG00190023186	protein coding gene	Chr4:44288390-44349985 (+)
NZO/HlLtJ	ENSMUSG00225002049	protein coding gene	Chr4:52584895-52646308 (+)
PWK/PhJ	ENSLUMG00010012239	protein coding gene	Chr4:43653959-43714148 (+)
SPRET/EiJ	ENSMSPG00010008552	protein coding gene	Chr4:44571532-44630826 (+)
WSB/EiJ	ENSIUOG00005004110	protein coding gene	Chr4:44034686-44096290 (+)

Human Ortholog

STX17, syntaxin 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STX17, syntaxin 17
Links

HGNC:11432

NCBI Gene ID: 55014

UniProt: P56962
Chr Location

9q31.1; chr9:99906654-99974534 (+) GRCh38

MGI Vertebrate Homology

Stx17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: STX17
Gene Tree

Stx17

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

4
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Loss of cardiac expression alleviates high fat diet induced cardiomyopathy.

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All GO Annotations

94
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

604
Tissues

1
cDNA Data

78
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN stx17

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All Sequences

63
RefSeq

10
UniProt

4
CCDS

CCDS18164.1

Ensembl

ENSMUSG00000061455 (Evidence)
NCBI Gene

67727

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061455	Ensembl Gene Model \| MGI Sequence Detail	61593	C57BL/6J	± kb
transcript	ENSMUST00000107720	Ensembl \| MGI Sequence Detail	5770	Not Applicable
polypeptide	ENSMUSP00000103348	Ensembl \| MGI Sequence Detail	301	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015789 syntaxin-17

(term hierarchy)
InterPro Domains

IPR010989 SNARE

IPR059001 STX17-like, N-terminal domain

IPR045242 Syntaxin

IPR028676 Syntaxin-17, SNARE motif

IPR006012 Syntaxin/epimorphin, conserved site

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 78

cDNA 78

Microarray probesets 9

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MGI:1917982, MGI:1921845, MGI:2140547

Summaries

All 48

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345305 Xu H, et al., Syntaxin17 contributes to obesity cardiomyopathy through promoting mitochondrial Ca(2+) overload in a Parkin-MCUb-dependent manner. Metabolism. 2023 Mar 21;143:155551

TSS for Stx17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37225	Chr4:48124903-48124938 (+)	6 bp
Tssr37226	Chr4:48124944-48124955 (+)	35 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24