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Slc25a37 Gene Detail
Summary
  • Symbol
    Slc25a37
  • Name
    solute carrier family 25, member 37
  • Synonyms
    1700020E22Rik, 4930513O14Rik, 4930526G11Rik, C330015G08Rik, Frascati, Mfrn, Mfrn1, mitoferrin, Mscp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914962
    NCBI Gene: 67712
  • Gene Overview
    MyGene.info: SLC25A37
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:69241848-69285103 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 36.03 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914962
protein coding gene Chr14:69241848-69285112 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021516
protein coding gene Chr14:64010321-64058869 (-)
A/J MGP_AJ_G0021475
protein coding gene Chr14:62496799-62542093 (-)
AKR/J MGP_AKRJ_G0021451
protein coding gene Chr14:64593027-64636182 (-)
BALB/cJ MGP_BALBcJ_G0021481
protein coding gene Chr14:62474222-62517749 (-)
C3H/HeJ MGP_C3HHeJ_G0021258
protein coding gene Chr14:64319099-64363686 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021920
protein coding gene Chr14:66933063-66978984 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019460
protein coding gene Chr14:60336532-60380041 (-)
CAST/EiJ MGP_CASTEiJ_G0020775
protein coding gene Chr14:60855504-60902035 (-)
CBA/J MGP_CBAJ_G0021225
protein coding gene Chr14:69021012-69064302 (-)
DBA/2J MGP_DBA2J_G0021348
protein coding gene Chr14:62097326-62141612 (-)
FVB/NJ MGP_FVBNJ_G0021327
protein coding gene Chr14:61515261-61558989 (-)
LP/J MGP_LPJ_G0021423
protein coding gene Chr14:65087791-65095546 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021356
protein coding gene Chr14:67973531-68020011 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021943
protein coding gene Chr14:63854538-63900208 (-)
PWK/PhJ MGP_PWKPhJ_G0020519
protein coding gene Chr14:58845869-58890990 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020352
protein coding gene Chr14:59781804-59824441 (-)
WSB/EiJ MGP_WSBEiJ_G0020828
protein coding gene Chr14:64149861-64197365 (-)



Homology
more
  • Human Ortholog
    SLC25A37, solute carrier family 25 member 37
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC25A37, solute carrier family 25 member 37
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HT015, MFRN, MFRN1, MSC, MSCP, PRO1278, PRO1584, PRO2217
  • Links
    NCBI Gene ID: 51312
    neXtProt AC: NX_Q9NYZ2
    UniProt: Q9NYZ2

  • Chr Location
    8p21.2; chr8:23528795-23575463 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out allele are pale, exhibit no hemoglobinization in the yolk sac and heart, and die during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67712 NCBI Gene Model | MGI Sequence Detail 43256 C57BL/6J ±  kb
    transcript NM_026331 RefSeq | MGI Sequence Detail 4162 C57BL/6  
    polypeptide Q920G8 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 23
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1922377, MGI:1925436, MGI:1925952, MGI:2145697
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:232376 Chung J, et al., Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. J Biol Chem. 2014 Mar 14;289(11):7835-43

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory