About   Help   FAQ
Kirrel3
Gene Detail
Symbol

Name
ID
Kirrel3
kin of IRRE like 3 (Drosophila)
MGI:1914953
Synonyms
1500010O20Rik, 2900036G11Rik, mKIAA1867, Neph2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
18.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:34485894-35036716 bp, + strand
From VEGA annotation of GRCm38

  550823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human
homologs
Human Homolog KIRREL3, kin of IRRE like 3 (Drosophila)
NCBI Gene ID 84623
neXtProt AC  NX_Q8IZU9
Human Synonyms  KIRRE, MRD4, NEPH2, PRO4502
Human Chr (Location)  11q24; chr11:126423493-127000870 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KIRREL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired accessory olfactory bulb formation with reduced coalescence of vomeronasal sensory neuron axons in the posterior accessory olfactory bulb, loss of male-male aggression and abnormal male sexual response to a male intruder mouse.
 
Interactions
Kirrel3 interacts with 214 markers (Mir7-1, Mir7-2, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process glomerulus morphogenesis, hemopoiesis, ...
Component axon, dendritic shaft, ...
Function PDZ domain binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (79)    Tissues (56)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 51
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016800 (Evidence)
Ensembl Gene ModelENSMUSG00000032036 (Evidence), ENSMUSG00000098841 (Evidence)
Entrez Gene67703 (Evidence)
DFCITC1612424, TC1594006, TC1594001, TC1588386, TC1580202
DoTSDT.102555440, DT.102544506, DT.101724295, DT.60118068, DT.55280491, DT.99853712, DT.94256843, DT.87036716, DT.99856306
NIA Mouse Gene IndexU010238
Consensus CDS ProjectCCDS40574.1, CCDS57667.1
International Mouse Knockout Project StatusKirrel3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016800 VEGA Gene Model | MGI Sequence Detail 550823 C57BL/6J ±  kb
transcript OTTMUST00000120078 VEGA | MGI Sequence Detail 3532 Not Applicable 
polypeptide OTTMUSP00000066617 VEGA | MGI Sequence Detail 777 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(26) UniProt(10)
Polymorphisms
SNPs within 2kb(5373 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5377)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000009343 kin of IRRE-like protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198564 Prince JE, et al., Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Development. 2013 Jun;140(11):2398-408
All references(38)
Other
accession IDs
MGI:1920101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory