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Kirrel3 Gene Detail
Summary
  • Symbol
    Kirrel3
  • Name
    kin of IRRE like 3 (Drosophila)
  • Synonyms
    1500010O20Rik, 2900036G11Rik, mKIAA1867, Neph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914953
    NCBI Gene: 67703
  • Gene Overview
    MyGene.info: KIRREL3
Location & Maps
more
  • Sequence Map
    Chr9:34485894-35036716 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      550823 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 18.97 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KIRREL3, kin of IRRE like 3 (Drosophila)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIRREL3, kin of IRRE like 3 (Drosophila)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIRRE, MRD4, NEPH2, PRO4502
  • Links
    NCBI Gene ID: 84623
    neXtProt AC: NX_Q8IZU9

  • Chr Location
    11q24; chr11:126423493-127003460 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIRREL3 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Dominant 4; MRD4   OMIM: 612581
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    4
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired accessory olfactory bulb formation with reduced coalescence of vomeronasal sensory neuron axons in the posterior accessory olfactory bulb, loss of male-male aggression and abnormal male sexual response to a male intruder mouse.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016800 VEGA Gene Model | MGI Sequence Detail 550823 C57BL/6J ±  kb
transcript OTTMUST00000120078 VEGA | MGI Sequence Detail 3532 Not Applicable  
polypeptide OTTMUSP00000066617 VEGA | MGI Sequence Detail 777 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5319 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
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MGI:1920101
References
more
  • Summaries
    All 37
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228054 Martin EA, et al., The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory