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Kirrel3
Gene Detail
Symbol

Name
ID
Kirrel3
kin of IRRE like 3 (Drosophila)
MGI:1914953
Synonyms
1500010O20Rik, 2900036G11Rik, mKIAA1867, Neph2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
18.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:34485894-35036716 bp, + strand
From VEGA annotation of GRCm38

  550823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: KIRREL3
Gene Tree: Kirrel3

Human
homologs
KIRREL3, kin of IRRE like 3 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84623
neXtProt AC: NX_Q8IZU9

Human Synonyms: KIRRE, MRD4, NEPH2, PRO4502

Human Chr (Location): 11q24; chr11:126423493-127003460 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KIRREL3

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired accessory olfactory bulb formation with reduced coalescence of vomeronasal sensory neuron axons in the posterior accessory olfactory bulb, loss of male-male aggression and abnormal male sexual response to a male intruder mouse.
 
Interactions
Kirrel3 interacts with 213 markers (Mir7-1, Mir7-2, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process glomerulus morphogenesis, hemopoiesis, ...
Component axon, dendritic shaft, ...
Function PDZ domain binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (79)    Tissues (56)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 51
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kirrel3    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016800 (Evidence)
Ensembl Gene Model ENSMUSG00000032036 (Evidence)
Entrez Gene 67703 (Evidence)
DFCI TC1612424, TC1594006, TC1594001, TC1588386, TC1580202
DoTS DT.99856306, DT.99853712, DT.60118068, DT.94256843, DT.55280491, DT.87036716, DT.102555440, DT.102544506, DT.101724295
NIA Mouse Gene Index U010238
Consensus CDS Project CCDS40574.1, CCDS57667.1
International Mouse Phenotyping Consortium Status Kirrel3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016800 VEGA Gene Model | MGI Sequence Detail 550823 C57BL/6J ±  kb
transcript OTTMUST00000120078 VEGA | MGI Sequence Detail 3532 Not Applicable 
polypeptide OTTMUSP00000066617 VEGA | MGI Sequence Detail 777 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(22) UniProt(7)
Polymorphisms
SNPs within 2kb(5373 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5377)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000009343 kin of IRRE-like protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220652 Ashrafi S, et al., Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord. Neuron. 2014 Jan 8;81(1):120-9
All references(38)
Other
accession IDs
MGI:1920101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory