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Dyx1c1 Gene Detail
Summary
  • Symbol
    Dyx1c1
  • Name
    dyslexia susceptibility 1 candidate 1
  • Synonyms
    1700010I24Rik, b2b811Clo, Dnaaf4, EKN1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914935
    NCBI Gene: 67685
Location & Maps
more
  • Sequence Map
    Chr9:72958785-72973064 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14280 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DYX1C1, dyslexia susceptibility 1 candidate 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DYX1C1, dyslexia susceptibility 1 candidate 1
    Orthology source: HomoloGene
  • Synonyms
    CILD25, DNAAF4, DYX1, DYXC1, EKN1, RD
  • Links
    NCBI Gene ID: 161582
    neXtProt AC: NX_Q8WXU2

  • Chr Location
    15q21.3; chr15:55417755-55508234 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dyx1c1 mouse models; 2 with human DYX1C1 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 25; CILD25   OMIM: 615482 View 1 model
       Dyslexia, Susceptibility to, 1; DYX1   OMIM: 127700
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    17 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Dyx1c1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033537 VEGA Gene Model | MGI Sequence Detail 14280 C57BL/6J ±  kb
transcript OTTMUST00000084414 VEGA | MGI Sequence Detail 1975 Not Applicable  
polypeptide OTTMUSP00000045495 VEGA | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 137
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006789 dyslexia susceptibility 1 candidate gene 1 protein
  • InterPro Domains
    IPR007052 CS domain
    IPR008978 HSP20-like chaperone
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
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MGI:5311341
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225195 Rendall AR, et al., Deficits in learning and memory in mice with a mutation of the candidate dyslexia susceptibility gene Dyx1c1. Brain Lang. 2015 May 16;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory