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Dyx1c1
Gene Detail
Symbol

Name
ID
Dyx1c1
dyslexia susceptibility 1 candidate 1 homolog (human)
MGI:1914935
Synonyms
1700010I24Rik, b2b811Clo, EKN1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
40.08 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:72958785-72973064 bp, + strand
From VEGA annotation of GRCm38

  14280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12173  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DYX1C1
Gene Tree: Dyx1c1

Human
homologs
DYX1C1, dyslexia susceptibility 1 candidate 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 161582
neXtProt AC: NX_Q8WXU2

Human Synonyms: CILD25, DNAAF4, DYX1, DYXC1, EKN1, RD

Human Chr (Location): 15q21.3; chr15:55417755-55508234 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DYX1C1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Human Diseases Modeled in Mice Using Dyx1c1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(10)
Interactions
Dyx1c1 interacts with 126 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cilium movement, determination of left/right symmetry, ...
Component cytoplasm, nucleus, ...
Function estrogen receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dyx1c1 ; ZFIN dyx1c1    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033537 (Evidence)
Ensembl Gene Model ENSMUSG00000092192 (Evidence)
Entrez Gene 67685 (Evidence)
UniGene 31817
DFCI TC1749266, TC1586364
DoTS DT.97371383, DT.94182366, DT.521651
NIA Mouse Gene Index U010730
Consensus CDS Project CCDS23333.1, CCDS52854.1
International Mouse Phenotyping Consortium Status Dyx1c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033537 VEGA Gene Model | MGI Sequence Detail 14280 C57BL/6J ±  kb
transcript OTTMUST00000084414 VEGA | MGI Sequence Detail 1975 Not Applicable 
polypeptide OTTMUSP00000045495 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007052 CS-like domain
InterPro IPR008978 HSP20-like chaperone
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000006789 dyslexia susceptibility 1 candidate gene 1 protein
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205312 Tarkar A, et al., DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013 Sep;45(9):995-1003
All references(31)
Disease annotation references (1)
Other
accession IDs
MGI:5311341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory