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Dyx1c1
Gene Detail
 Symbol
Name
ID
Dyx1c1
dyslexia susceptibility 1 candidate 1 homolog (human)
MGI:1914935
Synonyms 1700010I24Rik, b2b811Clo, EKN1
Feature Type protein coding gene
Genetic Map
Chromosome 9
40.08 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:72958785-72973064 bp, + strand
From VEGA annotation of GRCm38

  14280 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12173  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dyx1c1

Human
homologs
Human Homolog DYX1C1, dyslexia susceptibility 1 candidate 1
NCBI Gene ID 161582
neXtProt AC  NX_Q8WXU2
Human Synonyms  CILD25, DYX1, DYXC1, EKN1, RD
Human Chr (Location)  15q21.3; chr15:55417755-55508234 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DYX1C1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out or ENU induced allele exhibit a phenotype resembling primary ciliary dyskinesia with prenatal and postnatal lethality, hydroencephaly, varying degrees of situs inversus, domed cranium and ciliary motility defects in ependyma and respiratory cells.
 
Human Diseases Modeled Using Mouse Dyx1c1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(11)
Interactions
Dyx1c1 interacts with 126 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cilium movement, determination of left/right symmetry, ...
Component cytoplasm, nucleus, ...
Function estrogen receptor binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033537 (Evidence)
Ensembl Gene ModelENSMUSG00000092192 (Evidence)
Entrez Gene67685 (Evidence)
UniGene31817
DFCITC1586364, TC1749266
DoTSDT.521651, DT.94182366, DT.97371383
NIA Mouse Gene IndexU010730
Consensus CDS ProjectCCDS23333.1, CCDS52854.1
International Mouse Knockout Project StatusDyx1c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033537 VEGA Gene Model | MGI Sequence Detail 14280 C57BL/6J ±  kb
transcript OTTMUST00000084414 VEGA | MGI Sequence Detail 1975 Not Applicable 
polypeptide OTTMUSP00000045495 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007052 CS-like domain
InterPro IPR008978 HSP20-like chaperone
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000006789 dyslexia susceptibility 1 candidate gene 1 protein
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205312 Tarkar A, et al., DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013 Sep;45(9):995-1003
All references(31)
Disease annotation references (1)
Other
accession IDs
MGI:5311341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory