Mrpl18 MGI Mouse Gene Detail - MGI:1914931 - mitochondrial ribosomal protein L18

Symbol

Mrpl18
Name

mitochondrial ribosomal protein L18
Synonyms

1010001C05Rik, HSPC071, MRP-L18

Feature Type

protein coding gene
IDs

MGI:1914931
NCBI Gene: 67681
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:13130236-13135232 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 8.72 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914931	protein coding gene	Chr17:13130232-13136674 (-)
129S1/SvImJ	ENSMUSG00200031987	protein coding gene	Chr17:9361856-9366854 (-)
A/J	ENSMUSG00195022566	protein coding gene	Chr17:9561187-9566184 (-)
AKR/J	ENSMUSG00220026455	protein coding gene	Chr17:9629959-9634957 (-)
BALB/cJ	ENSMUSG00180024726	protein coding gene	Chr17:9210401-9215398 (-)
C3H/HeJ	ENSMUSG00175033339	protein coding gene	Chr17:9349814-9354810 (-)
C57BL/6NJ	ENSMUSG00215020417	protein coding gene	Chr17:9399599-9404595 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021044	protein coding gene	Chr17:4034153-4039384 (+)
CAST/EiJ	ENSTCUG00005020672	protein coding gene	Chr17:9599623-9604672 (-)
CBA/J	ENSMUSG00210036920	protein coding gene	Chr17:9013084-9018078 (-)
DBA/2J	ENSMUSG00185035861	protein coding gene	Chr17:10110726-10115723 (-)
FVB/NJ	ENSMUSG00205008871	protein coding gene	Chr17:9438615-9443612 (-)
JF1/MsJ	ENSUMUG00000033677	protein coding gene	Chr17:9709025-9714066 (-)
LP/J	ENSMUSG00230024733	protein coding gene	Chr17:11545501-11550498 (-)
NOD/ShiLtJ	ENSMUSG00190027031	protein coding gene	Chr17:9544771-9549765 (-)
NZO/HlLtJ	ENSMUSG00225047672	protein coding gene	Chr17:13464391-13469388 (-)
PWK/PhJ	ENSLUMG00010018120	protein coding gene	Chr17:9531024-9536060 (-)
SPRET/EiJ	ENSMSPG00010035623	protein coding gene	Chr17:4071148-4076000 (+)
WSB/EiJ	ENSIUOG00005012909	protein coding gene	Chr17:9436676-9441673 (-)

Human Ortholog

MRPL18, mitochondrial ribosomal protein L18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPL18, mitochondrial ribosomal protein L18
Synonyms

HSPC071, L18mt, MRP-L18, uL18m
Links

HGNC:14477

NCBI Gene ID: 29074

UniProt: Q9H0U6
Chr Location

6q25.3; chr6:159789812-159799027 (+) GRCh38

MGI Vertebrate Homology

Mrpl18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPL18
Gene Tree

Mrpl18

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Endonuclease-mediated

2
Gene trapped

25
Targeted

4
Genomic Mutations

1 involving Mrpl18
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

659
Tissues

49
cDNA Data

155
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrpl18

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS28396.1

Ensembl

ENSMUSG00000057388 (Evidence)
NCBI Gene

67681

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057388	Ensembl Gene Model \| MGI Sequence Detail	4997	C57BL/6J	± kb
transcript	ENSMUST00000079121	Ensembl \| MGI Sequence Detail	1219	Not Applicable
polypeptide	ENSMUSP00000078123	Ensembl \| MGI Sequence Detail	180	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010580 large ribosomal subunit protein uL18m

(term hierarchy)
PDB

9E9C, 9HCC, 9HCD, 9HCE, 9HCF, 9HCG, 9HCH
InterPro Domains

IPR057268 Large ribosomal subunit protein uL18

IPR005484 Large ribosomal subunit protein uL18, bacterial/plantae/animalia

IPR036967 Small ribosomal subunit protein uS11 superfamily
GlyGen

Q9CQL5 1 site, 1 O-linked glycan (1 site)

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All nucleic 156

cDNA 155

Primer pair 1

Microarray probesets 4

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MGI:2147133

Summaries

All 48

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mrpl18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146464	Chr17:13135678-13135718 (-)	-466 bp
Tssr146463	Chr17:13135276-13135295 (-)	-54 bp
Tssr146462	Chr17:13134978-13135006 (-)	240 bp
Tssr146461	Chr17:13134889-13134931 (-)	322 bp
Tssr146460	Chr17:13134522-13134543 (-)	699 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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