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Sdhb
Gene Detail
 Symbol
Name
ID
Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
MGI:1914930
Synonyms 0710008N11Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
73.24 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:140961203-140979193 bp, + strand
From VEGA annotation of GRCm38

  17991 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fumarate reductase/succinate dehydrogenase (ubiquinone), iron-sulfur protein
Gene Tree: Sdhb

Human
homologs
Human Homolog SDHB, succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
NCBI Gene ID 6390
neXtProt AC  NX_P21912
Human Synonyms  CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP
Human Chr (Location)  1p36.1-p35; chr1:17018722-17054170 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human SDHB
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sdhb interacts with 32 markers (Mir33, Mir139, Mir200a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process oxidation-reduction process, respiratory electron transport chain, ...
Component extracellular vesicular exosome, membrane, ...
Function 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (215)    Tissues (99)    Images (38)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 213
Western blot 2
cDNA source data(258)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(259) cDNA(258) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010087 (Evidence)
Ensembl Gene ModelENSMUSG00000009863 (Evidence)
Entrez Gene67680 (Evidence)
UniGene246965
DFCITC1573536
DoTSDT.101254943, DT.496467
NIA Mouse Gene IndexU005029
EC1.3.5.1
Consensus CDS ProjectCCDS18858.1
International Mouse Knockout Project StatusSdhb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010087 VEGA Gene Model | MGI Sequence Detail 17991 C57BL/6J ±  kb
transcript OTTMUST00000023450 VEGA | MGI Sequence Detail 1142 Not Applicable 
polypeptide OTTMUSP00000010715 VEGA | MGI Sequence Detail 282 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
InterPro IPR001041 2Fe-2S ferredoxin-type domain
InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulpur binding domain
InterPro IPR009051 Alpha-helical ferredoxin
InterPro IPR012675 Beta-grasp domain
InterPro IPR025192 Succinate dehydogenase/fumarate reductase N-terminal
InterPro IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Protein Ontology PR:000014564 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206222 Peralta S, et al., Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Hum Mol Genet. 2014 Mar 15;23(6):1399-412
All references(49)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory