Sdhb
Gene Detail

Symbol Name ID

Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) MGI:1914930

Synonyms

0710008N11Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 4

73.24 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:140961203-140979193 bp, + strand From VEGA annotation of GRCm38   17991 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Protein SuperFamily: fumarate reductase/succinate dehydrogenase (ubiquinone), iron-sulfur protein
Gene Tree: Sdhb

Human homologs

Human Homolog		SDHB, succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
NCBI Gene ID		6390
neXtProt AC		NX_P21912
Human Synonyms		CWS2, IP, PGL4, SDH, SDH1, SDH2, SDHIP
Human Chr (Location)		1p36.1-p35; chr1:17345217-17380665 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human SDHB

Alleles and phenotypes

All alleles(22) : Targeted(2) Gene trapped(20)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	electron transport chain, oxidation-reduction process, ...
Component	membrane, mitochondrial inner membrane, ...
Function	2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (215)    Tissues (99)    Images (38)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	213
Western blot	2

cDNA source data(260)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(261) cDNA(260) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000010087 (Evidence)
Ensembl Gene Model	ENSMUSG00000009863 (Evidence)
Entrez Gene	67680 (Evidence)
UniGene	246965
DFCI	TC1573536
DoTS	DT.101254943, DT.496467
NIA Mouse Gene Index	U005029
EC	1.3.5.1
Consensus CDS Project	CCDS18858.1
International Mouse Knockout Project Status	Sdhb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010087	VEGA Gene Model | MGI Sequence Detail	17991	C57BL/6J
transcript	OTTMUST00000023450	VEGA | MGI Sequence Detail	1142	Not Applicable
polypeptide	OTTMUSP00000010715	VEGA | MGI Sequence Detail	282	Not Applicable

All sequences(39) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(109 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site
InterPro	IPR001041	2Fe-2S ferredoxin-type domain
InterPro	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulpur binding domain
InterPro	IPR009051	Alpha-helical ferredoxin
InterPro	IPR012675	Beta-grasp domain
InterPro	IPR012285	Fumarate reductase, C-terminal
InterPro	IPR025192	Succinate dehydogenase/fumarate reductase N-terminal
InterPro	IPR004489	Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Protein Ontology	PR:000014564	succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:155116 Yang H, et al., Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. Hum Mol Genet. 2010 Jan 1;19(1):170-80
All references(45)