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Rpl38 Gene Detail
Summary
  • Symbol
    Rpl38
  • Name
    ribosomal protein L38
  • Synonyms
    0610025G13Rik, Rbt, Ts, Tss
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914921
    NCBI Gene: 67671
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:114559350-114563157 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 79.82 cM, cytoband G1
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914921
protein coding gene Chr11:114558644-114563159 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019356
protein coding gene Chr11:118591948-118596541 (+)
A/J MGP_AJ_G0019325
protein coding gene Chr11:113440345-113445296 (+)
AKR/J MGP_AKRJ_G0019293
protein coding gene Chr11:116786893-116791883 (+)
BALB/cJ MGP_BALBcJ_G0019298
protein coding gene Chr11:113861334-113865141 (+)
C3H/HeJ MGP_C3HHeJ_G0019107
protein coding gene Chr11:117141130-117145616 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019749
protein coding gene Chr11:122146831-122150638 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017372
protein coding gene Chr11:110507964-110511781 (+)
CAST/EiJ MGP_CASTEiJ_G0018661
protein coding gene Chr11:118459579-118469335 (+)
CBA/J MGP_CBAJ_G0019077
protein coding gene Chr11:127036423-127040403 (+)
DBA/2J MGP_DBA2J_G0019189
protein coding gene Chr11:112881214-112886646 (+)
FVB/NJ MGP_FVBNJ_G0019180
protein coding gene Chr11:112361461-112365268 (+)
LP/J MGP_LPJ_G0019259
protein coding gene Chr11:119003067-119007096 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019211
protein coding gene Chr11:126194132-126197939 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019786
protein coding gene Chr11:117464095-117467902 (+)
PWK/PhJ MGP_PWKPhJ_G0018426
protein coding gene Chr11:114116938-114121412 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018218
protein coding gene Chr11:117266562-117270372 (+)
WSB/EiJ MGP_WSBEiJ_G0018713
protein coding gene Chr11:117423285-117429805 (+)



Homology
more
  • Human Ortholog
    RPL38, ribosomal protein L38
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL38, ribosomal protein L38
  • Synonyms
    eL38, L38
  • Links
    NCBI Gene ID: 6169
    neXtProt AC: NX_P63173
    UniProt: P63173

  • Chr Location
    17q25.1; chr17:74203582-74210655 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with Rpl38 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    103 phenotypes from 3 alleles in 22 genetic backgrounds
    3 phenotypes from multigenic genotypes
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene affect growth and tail formation, and result in anterior and posterior homeotic vertebral transformations along the axial skeleton along with other abnormalities depending on genetic background. Homozygotes die in the early embryonic period.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057322 Ensembl Gene Model | MGI Sequence Detail 3808 C57BL/6J ±  kb
    transcript ENSMUST00000082092 Ensembl | MGI Sequence Detail 345 Not Applicable  
    polypeptide ENSMUSP00000080741 Ensembl | MGI Sequence Detail 70 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15255, MGD-MRK-37425, MGI:108385, MGI:1859966, MGI:98840
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:13063 MORGAN WC, A new tail-short mutation in the mouse whose lethal effects are conditioned by the residual genotypes. J Hered. 1950 Aug;41(8):208-15
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory