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Alkbh8 Gene Detail
Summary
  • Symbol
    Alkbh8
  • Name
    alkB homolog 8, tRNA methyltransferase
  • Synonyms
    4930562C03Rik, 8030431D03Rik, 9430088N01Rik, Abh8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914917
    NCBI Gene: 67667
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:3335231-3391154 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.02 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914917
protein coding gene Chr9:3335140-3391154 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034305
protein coding gene Chr9:21673-84599 (+)
A/J MGP_AJ_G0034282
protein coding gene Chr9:175998-231307 (+)
AKR/J MGP_AKRJ_G0034212
protein coding gene Chr9:70173-124174 (+)
BALB/cJ MGP_BALBcJ_G0034276
protein coding gene Chr9:27779-79098 (+)
C3H/HeJ MGP_C3HHeJ_G0033988
protein coding gene Chr9:168527-232600 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034798
protein coding gene Chr9:117498-177986 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0033315
protein coding gene Chr9:276489-331280 (+)
CBA/J MGP_CBAJ_G0033960
protein coding gene Chr9:11310-80647 (+)
DBA/2J MGP_DBA2J_G0034117
protein coding gene Chr9:181143-234339 (+)
FVB/NJ MGP_FVBNJ_G0034062
protein coding gene Chr9:11072-66090 (+)
LP/J MGP_LPJ_G0034204
protein coding gene Chr9:37941-90719 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034106
protein coding gene Chr9:149419-209638 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034817
protein coding gene Chr9:11059-63873 (+)
PWK/PhJ MGP_PWKPhJ_G0033019
protein coding gene Chr9:316155-371669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032856
protein coding gene Chr9:314002-374801 (+)
WSB/EiJ MGP_WSBEiJ_G0033431
protein coding gene Chr9:29808-92820 (+)



Homology
more
  • Human Ortholog
    ALKBH8, alkB homolog 8, tRNA methyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALKBH8, alkB homolog 8, tRNA methyltransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABH8, TRM9, TRMT9, TRMT9A
  • Links
    NCBI Gene ID: 91801
    neXtProt AC: NX_Q96BT7
    UniProt: Q96BT7

  • Chr Location
    11q22.3; chr11:107502726-107565740 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 44488
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ALKBH8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Homozygous mutants show no obvious phenotype at 20 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67667 NCBI Gene Model | MGI Sequence Detail 55924 C57BL/6J ±  kb
transcript NM_026303 RefSeq | MGI Sequence Detail 2300 Not Specified  
polypeptide Q80Y20 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924422, MGI:2442181
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236486 Ohshio I, et al., ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin. Biochem Biophys Res Commun. 2016 Aug 26;477(3):413-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory