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Spaca1 Gene Detail
Summary
  • Symbol
    Spaca1
  • Name
    sperm acrosome associated 1
  • Synonyms
    1700124L11Rik, 4930540L03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914902
    NCBI Gene: 67652
Location & Maps
more
  • Sequence Map
    Chr4:34024874-34050191 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25318 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 16.63 cM, cytoband A5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPACA1, sperm acrosome associated 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SPACA1, sperm acrosome associated 1
    Orthology source: HomoloGene
  • Synonyms
    SAMP32
  • Links
    NCBI Gene ID: 81833
    neXtProt AC: NX_Q9HBV2

  • Chr Location
    6q15; chr6:88047035-88066832 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically and radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Spaca1
  • Incidental Mutations
Homozygous null male mice are infertile and display globozoospermia and asthenozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008303 VEGA Gene Model | MGI Sequence Detail 25318 C57BL/6J ±  kb
transcript OTTMUST00000018897 VEGA | MGI Sequence Detail 1197 Not Applicable  
polypeptide OTTMUSP00000008681 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    88 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015448 sperm acrosome membrane-associated protein 1
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 2
Other
Accession IDs
less
MGI:1923894
References
more
  • Summaries
    All 20
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:187685 Fujihara Y, et al., SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development. 2012 Oct;139(19):3583-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory