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Samd8 Gene Detail
Summary
  • Symbol
    Samd8
  • Name
    sterile alpha motif domain containing 8
  • Synonyms
    1110053F04Rik, 1700010P07Rik, Smsr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914880
    NCBI Gene: 67630
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:21750531-21798725 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.86 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    380 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914880
protein coding gene Chr14:21750531-21798726 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021055
protein coding gene Chr14:14592614-14644369 (+)
A/J MGP_AJ_G0021004
protein coding gene Chr14:14208904-14259214 (+)
AKR/J MGP_AKRJ_G0020981
protein coding gene Chr14:14773786-14825508 (+)
BALB/cJ MGP_BALBcJ_G0021007
protein coding gene Chr14:14315868-14364500 (+)
C3H/HeJ MGP_C3HHeJ_G0020791
protein coding gene Chr14:14698835-14748902 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021440
protein coding gene Chr14:15073826-15119679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019008
protein coding gene Chr14:14523959-14573469 (+)
CAST/EiJ MGP_CASTEiJ_G0020315
protein coding gene Chr14:14507467-14557358 (+)
CBA/J MGP_CBAJ_G0020757
protein coding gene Chr14:15848025-15903133 (+)
DBA/2J MGP_DBA2J_G0020880
protein coding gene Chr14:14044457-14093601 (+)
FVB/NJ MGP_FVBNJ_G0020863
protein coding gene Chr14:13931747-13980439 (+)
LP/J MGP_LPJ_G0020956
protein coding gene Chr14:14800914-14850941 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020889
protein coding gene Chr14:15601450-15650866 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021473
protein coding gene Chr14:14553636-14604286 (+)
PWK/PhJ MGP_PWKPhJ_G0020064
protein coding gene Chr14:13631863-13680543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019886
protein coding gene Chr14:14370904-14419692 (+)
WSB/EiJ MGP_WSBEiJ_G0020371
protein coding gene Chr14:14546621-14600135 (+)



Homology
more
  • Human Ortholog
    SAMD8, sterile alpha motif domain containing 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SAMD8, sterile alpha motif domain containing 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-177, SMSr
  • Links
    NCBI Gene ID: 142891
    neXtProt AC: NX_Q96LT4
    UniProt: Q96LT4

  • Chr Location
    10q22.2; chr10:75099592-75182123 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased ceramide phosphoethanolamine synthase activity but normal liver, kidney and spleen histology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67630 NCBI Gene Model | MGI Sequence Detail 48195 C57BL/6J ±  kb
transcript NM_001359954 RefSeq | MGI Sequence Detail 7071 C57BL/6  
polypeptide Q9DA37 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916072
References
more
  • Summaries
    All 31
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228568 Bickert A, et al., Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice. J Lipid Res. 2015 Apr;56(4):821-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory