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4930453N24Rik Gene Detail
Summary
  • Symbol
    4930453N24Rik
  • Name
    RIKEN cDNA 4930453N24 gene
  • Synonyms
    din
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914859
    NCBI Gene: 67609
Location & Maps
more
  • Sequence Map
    Chr16:64751751-64771161 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 37.10 cM, cytoband C1.3
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    C3orf38, chromosome 3 open reading frame 38
  • Vertebrate Orthologs
    8
  • Human Ortholog
    C3orf38, chromosome 3 open reading frame 38
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 285237
    neXtProt AC: NX_Q5JPI3

  • Chr Location
    3p11.1; chr3:88149743-88157965 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    10
  • Spontaneous
    1
  • Targeted
    3
  • Incidental Mutations
Homozygous mutants show arrested eruption of incisors causing dentin formation to continue and occlude the pulp chamber. Mice also display small size, reduced ear pinna, and have abnormal coat color and patterning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028521 VEGA Gene Model | MGI Sequence Detail 19411 C57BL/6J ±  kb
transcript OTTMUST00000070685 VEGA | MGI Sequence Detail 5522 Not Applicable  
polypeptide OTTMUSP00000036063 VEGA | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR032710 NTF2-like domain
    IPR026698 Uncharacterised protein C3orf38 (DUF4518)
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-8848, MGI:2146476, MGI:94895
References
more
  • Summaries
    All 28
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:32738 Sweet HO, et al., Dense incisors (din): a new mouse mutation on chromosome 16 affecting tooth eruption and body size. J Hered. 1996 Mar-Apr;87(2):162-7
  • Latest
    J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2015 Jul 30;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory