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4930453N24Rik Gene Detail
Summary
  • Symbol
    4930453N24Rik
  • Name
    RIKEN cDNA 4930453N24 gene
  • Synonyms
    din
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914859
    NCBI Gene: 67609
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:64762205-64771156 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 37.10 cM, cytoband C1.3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914859
protein coding gene Chr16:64751751-64771161 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022940
protein coding gene Chr16:64256805-64277354 (-)
A/J MGP_AJ_G0022908
protein coding gene Chr16:61521900-61531203 (-)
AKR/J MGP_AKRJ_G0022878
protein coding gene Chr16:63384489-63406360 (-)
BALB/cJ MGP_BALBcJ_G0022910
protein coding gene Chr16:61718719-61740940 (-)
C3H/HeJ MGP_C3HHeJ_G0022672
protein coding gene Chr16:63731618-63746414 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023358
protein coding gene Chr16:66190347-66209795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020861
protein coding gene Chr16:60570535-60590240 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022643
protein coding gene Chr16:68936105-68954407 (-)
DBA/2J MGP_DBA2J_G0022775
protein coding gene Chr16:61270382-61285851 (-)
FVB/NJ MGP_FVBNJ_G0022749
protein coding gene Chr16:60887540-60902765 (-)
LP/J MGP_LPJ_G0022844
protein coding gene Chr16:64068545-64079638 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022768
protein coding gene Chr16:70172726-70192858 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023374
protein coding gene Chr16:63528456-63551001 (-)
PWK/PhJ MGP_PWKPhJ_G0021938
protein coding gene Chr16:61439377-61448480 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0022242
protein coding gene Chr16:63596895-63611151 (-)



Homology
more
  • Human Ortholog
    C3orf38, chromosome 3 open reading frame 38
  • Vertebrate Orthologs
    8
  • Human Ortholog
    C3orf38, chromosome 3 open reading frame 38
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 285237
    neXtProt AC: NX_Q5JPI3
    UniProt: Q5JPI3

  • Chr Location
    3p11.1; chr3:88149713-88157965 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants show arrested eruption of incisors causing dentin formation to continue and occlude the pulp chamber. Mice also display small size, reduced ear pinna, and have abnormal coat color and patterning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67609 NCBI Gene Model | MGI Sequence Detail 8952 C57BL/6J ±  kb
transcript NM_026273 RefSeq | MGI Sequence Detail 1331 C57BL/6  
polypeptide Q3TTL0 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR032710 NTF2-like domain superfamily
    IPR026698 Uncharacterised protein C3orf38 (DUF4518)
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-8848, MGI:2146476, MGI:94895
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:32738 Sweet HO, et al., Dense incisors (din): a new mouse mutation on chromosome 16 affecting tooth eruption and body size. J Hered. 1996 Mar-Apr;87(2):162-7
  • Latest
    J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2016 Jul 15;415(2):216-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory