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4930453N24Rik Gene Detail
Summary
  • Symbol
    4930453N24Rik
  • Name
    RIKEN cDNA 4930453N24 gene
  • Synonyms
    din
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914859
    NCBI Gene: 67609
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:64583267-64592735 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 37.10 cM, cytoband C1.3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914859
 protein coding gene Chr16:64572114-64592735 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022940
 protein coding gene Chr16:64256805-64277354 (-)
A/J MGP_AJ_G0022908
 protein coding gene Chr16:61521900-61531203 (-)
AKR/J MGP_AKRJ_G0022878
 protein coding gene Chr16:63384489-63406360 (-)
BALB/cJ MGP_BALBcJ_G0022910
 protein coding gene Chr16:61718719-61740940 (-)
C3H/HeJ MGP_C3HHeJ_G0022672
 protein coding gene Chr16:63731618-63746414 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023358
 protein coding gene Chr16:66190347-66209795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020861
 protein coding gene Chr16:60570535-60590240 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022643
 protein coding gene Chr16:68936105-68954407 (-)
DBA/2J MGP_DBA2J_G0022775
 protein coding gene Chr16:61270382-61285851 (-)
FVB/NJ MGP_FVBNJ_G0022749
 protein coding gene Chr16:60887540-60902765 (-)
LP/J MGP_LPJ_G0022844
 protein coding gene Chr16:64068545-64079638 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022768
 protein coding gene Chr16:70172726-70192858 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023374
 protein coding gene Chr16:63528456-63551001 (-)
PWK/PhJ MGP_PWKPhJ_G0021938
 protein coding gene Chr16:61439377-61448480 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0022242
 protein coding gene Chr16:63596895-63611151 (-)



Homology
more
  • Human Ortholog
    C3orf38, chromosome 3 open reading frame 38
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C3orf38, chromosome 3 open reading frame 38
  • Links
    NCBI Gene ID: 285237
    neXtProt AC: NX_Q5JPI3
    UniProt: Q5JPI3

  • Chr Location
    3p11.1; chr3:88149959-88168729 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show arrested eruption of incisors causing dentin formation to continue and occlude the pulp chamber. Mice also display small size, reduced ear pinna, and have abnormal coat color and patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67609 NCBI Gene Model | MGI Sequence Detail 9469 C57BL/6J ±  kb
    transcript NM_026273 RefSeq | MGI Sequence Detail 1331 C57BL/6  
    polypeptide Q3TTL0 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-8848, MGI:2146476, MGI:94895
    References
    more
    • Summaries
      All 31
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:32738 Sweet HO, et al., Dense incisors (din): a new mouse mutation on chromosome 16 affecting tooth eruption and body size. J Hered. 1996 Mar-Apr;87(2):162-7
    • Latest
      J:223062 Palmer K, et al., Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology. Dev Biol. 2016 Jul 15;415(2):216-27
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory