Akt1s1 MGI Mouse Gene Detail - MGI:1914855

Symbol

Akt1s1
Name

AKT1 substrate 1
Synonyms

1110012J22Rik, Lobe, PRAS40

Feature Type

protein coding gene
IDs

MGI:1914855
NCBI Gene: 67605
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:44498648-44504845 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 28.94 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914855	protein coding gene	Chr7:44498415-44504845 (+)
129S1/SvImJ	ENSMUSG00200027911	protein coding gene	Chr7:32094070-32100498 (+)
A/J	ENSMUSG00195037492	protein coding gene	Chr7:36122137-36128566 (+)
AKR/J	ENSMUSG00220007321	protein coding gene	Chr7:30427111-30433541 (+)
BALB/cJ	ENSMUSG00180036384	protein coding gene	Chr7:32997530-33003958 (+)
C3H/HeJ	ENSMUSG00175031228	protein coding gene	Chr7:33530000-33536428 (+)
C57BL/6NJ	ENSMUSG00215043778	protein coding gene	Chr7:32791168-32797598 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029678	protein coding gene	Chr7:46782931-46789407 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210048284	protein coding gene	Chr7:33901365-33907793 (+)
DBA/2J	ENSMUSG00185045355	protein coding gene	Chr7:37773996-37780424 (+)
FVB/NJ	ENSMUSG00205045125	protein coding gene	Chr7:33446706-33453136 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230051499	protein coding gene	Chr7:43203320-43209751 (+)
NOD/ShiLtJ	ENSMUSG00190027866	protein coding gene	Chr7:33774467-33780897 (+)
NZO/HlLtJ	ENSMUSG00225014138	protein coding gene	Chr7:41411905-41418336 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

AKT1S1, AKT1 substrate 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AKT1S1, AKT1 substrate 1
Synonyms

Lobe, PRAS40
Links

HGNC:28426

NCBI Gene ID: 84335

UniProt: Q96B36
Chr Location

19q13.33; chr19:49869033-49879470 (-) GRCh38

MGI Vertebrate Homology

Akt1s1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AKT1S1
Gene Tree

Akt1s1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

3
Gene trapped

34
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

Mice homozygous for a knock-out allele exhibit increased susceptibility to induced ischemic brain injury.

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All GO Annotations

32
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

620
Tissues

6
cDNA Data

16
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase akt1s1

ZFIN akt1s1

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All Sequences

102
RefSeq

26
UniProt

10
CCDS

CCDS21218.1, CCDS71954.1

Ensembl

ENSMUSG00000011096 (Evidence)
NCBI Gene

67605

			Length	Strain/Species	Flank
genomic	67605	NCBI Gene Model \| MGI Sequence Detail	6198	C57BL/6J	± kb
transcript	NM_001382480	RefSeq \| MGI Sequence Detail	2264	ZRU/MplStud
polypeptide	Q9D1F4	UniProt \| EBI \| MGI Sequence Detail	257	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000003911 proline-rich AKT1 substrate 1

(term hierarchy)
InterPro Domains

IPR055192 Proline-rich AKT1 substrate 1, N-terminal domain

IPR026682 Proline-rich AKT1 substrate 1 protein
GlyGen

Q9D1F4 2 sites, 1 O-linked glycan (1 site)

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All nucleic 16

cDNA 16

Antibodies 2

Microarray probesets 6

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MGI:2141884

Summaries

All 68

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:258057 Corbit KC, et al., Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. 2018 Feb;67(2):208-221

TSS for Akt1s1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66435	Chr7:44498518-44498538 (+)	-120 bp
Tssr66436	Chr7:44498640-44498719 (+)	32 bp
Tssr66438	Chr7:44499373-44499450 (+)	764 bp
Tssr66439	Chr7:44499788-44499816 (+)	1,154 bp
Tssr66440	Chr7:44499817-44499838 (+)	1,180 bp
Tssr66441	Chr7:44502200-44502247 (+)	3,576 bp
Tssr66442	Chr7:44504013-44504039 (+)	5,378 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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