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Akt1s1 Gene Detail
Summary
  • Symbol
    Akt1s1
  • Name
    AKT1 substrate 1 (proline-rich)
  • Synonyms
    1110012J22Rik, Lobe, PRAS40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914855
    NCBI Gene: 67605
  • Gene Overview
    MyGene.info: AKT1S1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44849126-44855421 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.94 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914855
protein coding gene Chr7:44848991-44855421 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032181
protein coding gene Chr7:45057018-45063446 (+)
A/J MGP_AJ_G0032160
protein coding gene Chr7:44212536-44218964 (+)
AKR/J MGP_AKRJ_G0032096
protein coding gene Chr7:45428474-45434904 (+)
BALB/cJ MGP_BALBcJ_G0032172
protein coding gene Chr7:44212308-44218736 (+)
C3H/HeJ MGP_C3HHeJ_G0031888
protein coding gene Chr7:45931482-45937910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032664
protein coding gene Chr7:47321251-47327681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029678
protein coding gene Chr7:46782931-46789407 (+)
CAST/EiJ MGP_CASTEiJ_G0031216
protein coding gene Chr7:37299783-37306230 (+)
CBA/J MGP_CBAJ_G0031852
protein coding gene Chr7:48871713-48878141 (+)
DBA/2J MGP_DBA2J_G0032010
protein coding gene Chr7:43883407-43889835 (+)
FVB/NJ MGP_FVBNJ_G0031961
protein coding gene Chr7:43659700-43666130 (+)
LP/J MGP_LPJ_G0032088
protein coding gene Chr7:45739475-45745906 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031998
protein coding gene Chr7:47609600-47616030 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032680
protein coding gene Chr7:44652714-44659145 (+)
PWK/PhJ MGP_PWKPhJ_G0030939
protein coding gene Chr7:37247555-37253968 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030776
protein coding gene Chr7:32653517-32659972 (+)
WSB/EiJ MGP_WSBEiJ_G0031333
protein coding gene Chr7:45127481-45133908 (+)



Homology
more
  • Human Ortholog
    AKT1S1, AKT1 substrate 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AKT1S1, AKT1 substrate 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Lobe, PRAS40
  • Links
    NCBI Gene ID: 84335
    neXtProt AC: NX_Q96B36
    UniProt: Q96B36

  • Chr Location
    19q13.33; chr19:49869033-49878356 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to induced ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67605 NCBI Gene Model | MGI Sequence Detail 6296 C57BL/6J ±  kb
transcript NM_001290694 RefSeq | MGI Sequence Detail 1857 C57BL/6  
polypeptide Q9D1F4 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR026682 Proline-rich AKT1 substrate 1 protein
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
less
MGI:2141884
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:248325 Figlia G, et al., Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. Elife. 2017 Sep 07;6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory