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Necap1 Gene Detail
Summary
  • Symbol
    Necap1
  • Name
    NECAP endocytosis associated 1
  • Synonyms
    1200016B17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914852
    NCBI Gene: 67602
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:122874557-122888941 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914852
protein coding gene Chr6:122874474-122888941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031235
protein coding gene Chr6:125996791-126013389 (+)
A/J MGP_AJ_G0031204
protein coding gene Chr6:121222695-121237890 (+)
AKR/J MGP_AKRJ_G0031134
protein coding gene Chr6:124579783-124596577 (+)
BALB/cJ MGP_BALBcJ_G0031214
protein coding gene Chr6:120934865-120950621 (+)
C3H/HeJ MGP_C3HHeJ_G0030933
protein coding gene Chr6:124546343-124560842 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031673
protein coding gene Chr6:129322186-129343951 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028830
protein coding gene Chr6:117823210-117837644 (+)
CAST/EiJ MGP_CASTEiJ_G0030322
protein coding gene Chr6:124808650-124825848 (+)
CBA/J MGP_CBAJ_G0030896
protein coding gene Chr6:134361605-134375912 (+)
DBA/2J MGP_DBA2J_G0031052
protein coding gene Chr6:120153896-120169698 (+)
FVB/NJ MGP_FVBNJ_G0031005
protein coding gene Chr6:119086533-119101575 (+)
LP/J MGP_LPJ_G0031133
protein coding gene Chr6:126189471-126206412 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031040
protein coding gene Chr6:138316909-138338884 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031703
protein coding gene Chr6:124466148-124482887 (+)
PWK/PhJ MGP_PWKPhJ_G0030036
protein coding gene Chr6:118993961-119009043 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029864
protein coding gene Chr6:122612348-122626413 (+)
WSB/EiJ MGP_WSBEiJ_G0030404
protein coding gene Chr6:124784213-124798814 (+)



Homology
more
  • Human Ortholog
    NECAP1, NECAP endocytosis associated 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NECAP1, NECAP endocytosis associated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIEE21
  • Links
    NCBI Gene ID: 25977
    neXtProt AC: NX_Q8NC96
    UniProt: Q8NC96

  • Chr Location
    12p13.31; chr12:8082211-8097777 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NECAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67602 NCBI Gene Model | MGI Sequence Detail 14385 C57BL/6J ±  kb
transcript NM_026267 RefSeq | MGI Sequence Detail 2408 C57BL/6  
polypeptide Q9CR95 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    cDNA 86

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141467
References
more
  • Summaries
    All 32
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:245326 Ritter B, et al., NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. PLoS Biol. 2013 Oct;11(10):e1001670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory