About   Help   FAQ
Uchl5 Gene Detail
Summary
  • Symbol
    Uchl5
  • Name
    ubiquitin carboxyl-terminal esterase L5
  • Synonyms
    5830413B11Rik, Uch37
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914848
    NCBI Gene: 56207
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:143777272-143807466 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.54 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914848
protein coding gene Chr1:143777218-143807466 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016564
protein coding gene Chr1:148134733-148167268 (+)
A/J MGP_AJ_G0016547
protein coding gene Chr1:142226882-142260960 (+)
AKR/J MGP_AKRJ_G0016512
protein coding gene Chr1:146593420-146625193 (+)
BALB/cJ MGP_BALBcJ_G0016507
protein coding gene Chr1:142650467-142683043 (+)
C3H/HeJ MGP_C3HHeJ_G0016332
protein coding gene Chr1:146708660-146739480 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016968
protein coding gene Chr1:153125937-153161565 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014677
protein coding gene Chr1:135038278-135069029 (+)
CAST/EiJ MGP_CASTEiJ_G0015911
protein coding gene Chr1:146130563-146163243 (+)
CBA/J MGP_CBAJ_G0016306
protein coding gene Chr1:158570705-158613287 (+)
DBA/2J MGP_DBA2J_G0016412
protein coding gene Chr1:141323705-141360926 (+)
FVB/NJ MGP_FVBNJ_G0016410
protein coding gene Chr1:139814223-139847357 (+)
LP/J MGP_LPJ_G0016483
protein coding gene Chr1:149148814-149182520 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016436
protein coding gene Chr1:164997825-165046296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017004
protein coding gene Chr1:146319711-146354335 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015484
protein coding gene Chr1:145120057-145156451 (+)
WSB/EiJ MGP_WSBEiJ_G0015974
protein coding gene Chr1:146356598-146389319 (+)



Homology
more
  • Human Ortholog
    UCHL5, ubiquitin C-terminal hydrolase L5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UCHL5, ubiquitin C-terminal hydrolase L5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-70, INO80R, UCH37, UCH-L5
  • Links
    NCBI Gene ID: 51377
    neXtProt AC: NX_Q9Y5K5
    UniProt: Q9Y5K5

  • Chr Location
    1q31.2; chr1:193012366-193060140 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality associated with abnormal brain development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018189 Ensembl Gene Model | MGI Sequence Detail 30195 C57BL/6J ±  kb
    transcript ENSMUST00000189936 Ensembl | MGI Sequence Detail 1696 Not Applicable  
    polypeptide ENSMUSP00000140106 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 7
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:242651 Kim SK, et al., Strain survey and genetic analysis of vasoreactivity in mouse aorta. Physiol Genomics. 2016 Oct 07;:physiolgenomics.00054.2016

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory