Tespa1 MGI Mouse Gene Detail - MGI:1914846 - thymocyte expressed, positive selection associated 1

Symbol

Tespa1
Name

thymocyte expressed, positive selection associated 1
Synonyms

5830405N20Rik, A430001F24Rik, Itprid3

Feature Type

protein coding gene
IDs

MGI:1914846
NCBI Gene: 67596
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:130158696-130199338 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.85 cM
Mapping Data

2 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914846	protein coding gene	Chr10:130158696-130199980 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017949	protein coding gene	Chr10:134282305-134326028 (+)
A/J	MGP_AJ_G0017919	protein coding gene	Chr10:128833790-128872989 (+)
AKR/J	MGP_AKRJ_G0017883	protein coding gene	Chr10:132612233-132657139 (+)
BALB/cJ	MGP_BALBcJ_G0017889	protein coding gene	Chr10:129278151-129322175 (+)
C3H/HeJ	MGP_C3HHeJ_G0017704	protein coding gene	Chr10:132806574-132851058 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018344	protein coding gene	Chr10:138829914-138880678 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016003	protein coding gene	Chr10:122577179-122616523 (+)
CAST/EiJ	MGP_CASTEiJ_G0017267	protein coding gene	Chr10:133523818-133560963 (+)
CBA/J	MGP_CBAJ_G0017677	protein coding gene	Chr10:144486032-144534239 (+)
DBA/2J	MGP_DBA2J_G0017787	protein coding gene	Chr10:127951585-127996136 (+)
FVB/NJ	MGP_FVBNJ_G0017779	protein coding gene	Chr10:126838556-126878896 (+)
LP/J	MGP_LPJ_G0017859	protein coding gene	Chr10:134836332-134881485 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017808	protein coding gene	Chr10:147106634-147144082 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018380	protein coding gene	Chr10:132689115-132732071 (+)
PWK/PhJ	MGP_PWKPhJ_G0017047	protein coding gene	Chr10:128082538-128124638 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016841	protein coding gene	Chr10:131712539-131748654 (+)
WSB/EiJ	MGP_WSBEiJ_G0017320	protein coding gene	Chr10:132954547-132997408 (+)

Human Ortholog

TESPA1, thymocyte expressed, positive selection associated 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TESPA1, thymocyte expressed, positive selection associated 1
Synonyms

HSPC257, ITPRID3, KIAA0748
Links

HGNC:29109

NCBI Gene ID: 9840

neXtProt AC: NX_A2RU30

UniProt: A2RU30
Chr Location

12q13.2; chr12:54948015-54985188 (-) GRCh38

MGI Vertebrate Homology

Tespa1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TESPA1
Gene Tree

Tespa1

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired late thymocyte development.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

4
cDNA Data

23
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS48735.1

Ensembl

ENSMUSG00000034833 (Evidence)
NCBI Gene

67596

			Length	Strain/Species	Flank
genomic	67596	NCBI Gene Model \| MGI Sequence Detail	40643	C57BL/6J	± kb
transcript	NM_183264	RefSeq \| MGI Sequence Detail	1694	Not Specified
polypeptide	Q3U132	UniProt \| EBI \| MGI Sequence Detail	458	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031130 protein TESPA1

(term hierarchy)
InterPro Domains

IPR029325 ITPR-interacting domain

IPR043444 Protein TESPA1-like

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All nucleic 25

cDNA 25

Microarray probesets 4

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MGI:2143610, MGI:2444602

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340599 Yang R, et al., Tespa1 deficiency reduces the antitumour immune response by decreasing CD8(+)T cell activity in a mouse Lewis lung cancer model. Int Immunopharmacol. 2023 Sep 1;124(Pt A):110865

TSS for Tespa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96488	Chr10:130158696-130158711 (+)	8 bp
Tssr96489	Chr10:130158714-130158725 (+)	24 bp
Tssr96490	Chr10:130158738-130158774 (+)	60 bp
Tssr96491	Chr10:130158784-130158793 (+)	93 bp
Tssr96492	Chr10:130166841-130166848 (+)	8,149 bp
Tssr96493	Chr10:130166851-130166900 (+)	8,180 bp
Tssr96494	Chr10:130168845-130168857 (+)	10,155 bp
Tssr96495	Chr10:130190338-130190342 (+)	31,644 bp
Tssr96496	Chr10:130196961-130196964 (+)	38,267 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23