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Tbc1d23 Gene Detail
Summary
  • Symbol
    Tbc1d23
  • Name
    TBC1 domain family, member 23
  • Synonyms
    4930451A13Rik, D030022P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914831
    NCBI Gene: 67581
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:57168862-57231504 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    672 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914831
protein coding gene Chr16:57168858-57231533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022896
protein coding gene Chr16:56320062-56378978 (-)
A/J MGP_AJ_G0022863
protein coding gene Chr16:53905828-53961131 (-)
AKR/J MGP_AKRJ_G0022835
protein coding gene Chr16:55609143-55665094 (-)
BALB/cJ MGP_BALBcJ_G0022863
protein coding gene Chr16:54009445-54065039 (-)
C3H/HeJ MGP_C3HHeJ_G0022626
protein coding gene Chr16:55799428-55860127 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023311
protein coding gene Chr16:57883346-57945736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020822
protein coding gene Chr16:53557409-53611675 (-)
CAST/EiJ MGP_CASTEiJ_G0022153
protein coding gene Chr16:56185297-56244291 (-)
CBA/J MGP_CBAJ_G0022599
protein coding gene Chr16:60228247-60290801 (-)
DBA/2J MGP_DBA2J_G0022731
protein coding gene Chr16:53643215-53700350 (-)
FVB/NJ MGP_FVBNJ_G0022706
protein coding gene Chr16:53402825-53465882 (-)
LP/J MGP_LPJ_G0022798
protein coding gene Chr16:56143496-56198866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022724
protein coding gene Chr16:60571630-60630004 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023326
protein coding gene Chr16:55753390-55810454 (-)
PWK/PhJ MGP_PWKPhJ_G0021892
protein coding gene Chr16:53953733-54010431 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021722
protein coding gene Chr16:55532444-55591351 (-)
WSB/EiJ MGP_WSBEiJ_G0022197
protein coding gene Chr16:55798280-55858648 (-)



Homology
more
  • Human Ortholog
    TBC1D23, TBC1 domain family member 23
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBC1D23, TBC1 domain family member 23
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NS4ATP1, PCH11
  • Links
    NCBI Gene ID: 55773
    neXtProt AC: NX_Q9NUY8
    UniProt: Q9NUY8

  • Chr Location
    3q12.1-q12.2; chr3:100260817-100325252 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit increased serum cytokine production and inflammatory cells in the peritoneum following i.p. lipopolysaccharide injection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022749 Ensembl Gene Model | MGI Sequence Detail 62643 C57BL/6J ±  kb
transcript ENSMUST00000226586 Ensembl | MGI Sequence Detail 3112 Not Applicable  
polypeptide ENSMUSP00000154535 Ensembl | MGI Sequence Detail 699 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 109
    cDNA 109

    Microarray probesets 5
Other
Accession IDs
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MGI:2146539, MGI:2146578, MGI:2146579, MGI:2146737, MGI:2444361
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:249681 Shin JJH, et al., TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. Nat Cell Biol. 2017 Dec;19(12):1424-1432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory