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Cpeb4 Gene Detail
Summary
  • Symbol
    Cpeb4
  • Name
    cytoplasmic polyadenylation element binding protein 4
  • Synonyms
    4930447D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914829
    NCBI Gene: 67579
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:31872226-31935634 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63409 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 18.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CPEB4, cytoplasmic polyadenylation element binding protein 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CPEB4, cytoplasmic polyadenylation element binding protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CPE-BP4, hCPEB-4
  • Links
    NCBI Gene ID: 80315
    neXtProt AC: NX_Q17RY0
    UniProt: Q17RY0

  • Chr Location
    5q35.2; chr5:173888328-173960991 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12736
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CPEB4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show slightly longer dendritic spines but normal hippocampal synaptic plasticity and memory. Homozygotes for a different null allele show neo- and postnatal lethality, erythropoiesis, suckling and mobility defects, and reduced motor axon branching and NMJ formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005363 VEGA Gene Model | MGI Sequence Detail 63409 C57BL/6J ±  kb
    transcript OTTMUST00000011965 VEGA | MGI Sequence Detail 6303 Not Applicable  
    polypeptide OTTMUSP00000005534 VEGA | MGI Sequence Detail 712 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      396 from dbSNP Build 142
    Protein
    Information
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    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005808 cytoplasmic polyadenylation element-binding protein 4
    • InterPro Domains
      IPR038446 CEBP, ZZ domain superfamily
      IPR034819 Cytoplasmic polyadenylation element-binding protein
      IPR032296 Cytoplasmic polyadenylation element-binding protein, ZZ domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
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    • All nucleic 74
      cDNA 73
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144310
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:244622 Maillo C, et al., Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. Nat Cell Biol. 2017 Feb;19(2):94-105

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory