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Loxl4 Gene Detail
Summary
  • Symbol
    Loxl4
  • Name
    lysyl oxidase-like 4
  • Synonyms
    4833426I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914823
    NCBI Gene: 67573
  • Gene Overview
    MyGene.info: LOXL4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42593982-42612813 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.56 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914823
protein coding gene Chr19:42592279-42612813 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025147
protein coding gene Chr19:41932414-41951455 (-)
A/J MGP_AJ_G0025124
protein coding gene Chr19:39922731-39941426 (-)
AKR/J MGP_AKRJ_G0025092
protein coding gene Chr19:41213370-41232074 (-)
BALB/cJ MGP_BALBcJ_G0025118
protein coding gene Chr19:39980751-40000278 (-)
C3H/HeJ MGP_C3HHeJ_G0024878
protein coding gene Chr19:41368763-41387468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025561
protein coding gene Chr19:43006192-43031644 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022975
protein coding gene Chr19:39275371-39294239 (-)
CAST/EiJ MGP_CASTEiJ_G0024343
protein coding gene Chr19:41067454-41086233 (-)
CBA/J MGP_CBAJ_G0024858
protein coding gene Chr19:45086460-45105156 (-)
DBA/2J MGP_DBA2J_G0024990
protein coding gene Chr19:39763048-39781735 (-)
FVB/NJ MGP_FVBNJ_G0024951
protein coding gene Chr19:39537744-39556478 (-)
LP/J MGP_LPJ_G0025076
protein coding gene Chr19:41916911-41935617 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024982
protein coding gene Chr19:44703931-44722640 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025619
protein coding gene Chr19:41278813-41297418 (-)
PWK/PhJ MGP_PWKPhJ_G0024092
protein coding gene Chr19:39664113-39683689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023896
protein coding gene Chr19:40019445-40040245 (-)
WSB/EiJ MGP_WSBEiJ_G0024413
protein coding gene Chr19:41418083-41436798 (-)



Homology
more
  • Human Ortholog
    LOXL4, lysyl oxidase like 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LOXL4, lysyl oxidase like 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LOXC
  • Links
    NCBI Gene ID: 84171
    neXtProt AC: NX_Q96JB6
    UniProt: Q96JB6

  • Chr Location
    10q24.2; chr10:98247686-98268250 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12977
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LOXL4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025185 Ensembl Gene Model | MGI Sequence Detail 18832 C57BL/6J ±  kb
transcript ENSMUST00000164786 Ensembl | MGI Sequence Detail 2617 Not Applicable  
polypeptide ENSMUSP00000125803 Ensembl | MGI Sequence Detail 758 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:239184 Zhang J, et al., Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development in Mice. Sci Rep. 2016 Sep 20;6:33856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory