About   Help   FAQ
Mrfap1 Gene Detail
Summary
  • Symbol
    Mrfap1
  • Name
    Morf4 family associated protein 1
  • Synonyms
    9130413I22Rik, PAM14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914818
    NCBI Gene: 67568
  • Gene Overview
    MyGene.info: MRFAP1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36794867-36796754 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914818
protein coding gene Chr5:36794867-36796772 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0023802
protein coding gene Chr17:47352064-47353822 (+)
AKR/J MGP_AKRJ_G0029410
protein coding gene Chr5:35256459-35257387 (-)
BALB/cJ MGP_BALBcJ_G0029471
protein coding gene Chr5:34472435-34474929 (-)
C3H/HeJ MGP_C3HHeJ_G0029193
protein coding gene Chr5:35260414-35262576 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029925
protein coding gene Chr5:37039742-37043006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027162
protein coding gene Chr5:31698904-31700824 (-)
CAST/EiJ MGP_CASTEiJ_G0028602
protein coding gene Chr5:34398045-34401217 (-)
CBA/J MGP_CBAJ_G0029161
protein coding gene Chr5:37942448-37947634 (-)
DBA/2J MGP_DBA2J_G0023672
protein coding gene Chr17:46109614-46111620 (+)
FVB/NJ MGP_FVBNJ_G0023639
protein coding gene Chr17:45755175-45756330 (+)
LP/J MGP_LPJ_G0023753
protein coding gene Chr17:49230317-49231709 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0029958
protein coding gene Chr5:34745086-34749211 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028158
protein coding gene Chr5:34217048-34218958 (-)
WSB/EiJ MGP_WSBEiJ_G0028683
protein coding gene Chr5:34830267-34834446 (-)



Homology
more
  • Human Ortholog
    MRFAP1, Morf4 family associated protein 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MRFAP1, Morf4 family associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAM14, PGR1, PGR1`
  • Links
    NCBI Gene ID: 93621
    neXtProt AC: NX_Q9Y605
    UniProt: Q9Y605

  • Chr Location
    4p16.1; chr4:6640091-6642745 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    8 involving Mrfap1
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous null mice are viable, fertile, develop normally, have normal T cell development and function, and produce MEFs with normal growth rates and times to senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67568 NCBI Gene Model | MGI Sequence Detail 1888 C57BL/6J ±  kb
transcript NM_026242 RefSeq | MGI Sequence Detail 1630 C57BL/6  
polypeptide Q9CQL7 UniProt | EBI | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR029254 MORF4 family-associated protein 1
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141014
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 24
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:125425 Howell GR, et al., Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Genetics. 2007 Feb;175(2):699-707

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory