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Narfl Gene Detail
Summary
  • Symbol
    Narfl
  • Name
    nuclear prelamin A recognition factor-like
  • Synonyms
    9030612I22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914813
    NCBI Gene: 67563
Location & Maps
more
  • Sequence Map
    Chr17:25773776-25783332 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9557 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.88 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NARFL, nuclear prelamin A recognition factor like
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NARFL, nuclear prelamin A recognition factor like
    Orthology source: HomoloGene
  • Synonyms
    HPRN, IOP1, LET1L, NAR1, PRN
  • Links
    NCBI Gene ID: 64428
    neXtProt AC: NX_Q9H6Q4

  • Chr Location
    16p13.3; chr16:729753-741038 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 6750
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NARFL
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    2 involving Narfl
  • Incidental Mutations
Mice homozygous for a targeted knock-out die before E10.5. Mice heterozygous for a targeted allele exhibit partial lethality between E10.5 and birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033885 VEGA Gene Model | MGI Sequence Detail 9557 C57BL/6J ±  kb
transcript OTTMUST00000085443 VEGA | MGI Sequence Detail 2062 Not Applicable  
polypeptide OTTMUSP00000046159 VEGA | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    29 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010988 cytosolic Fe-S cluster assembly factor NARFL
  • InterPro Domains
    IPR009016 Iron hydrogenase
    IPR004108 Iron hydrogenase, large subunit, C-terminal
    IPR003149 Iron hydrogenase, small subunit
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 4
Other
Accession IDs
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MGI:2146884
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory