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Larp6 Gene Detail
Summary
  • Symbol
    Larp6
  • Name
    La ribonucleoprotein 6, translational regulator
  • Synonyms
    5430431G03Rik, acheron, Achn
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914807
    NCBI Gene: 67557
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:60620404-60646084 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 32.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914807
protein coding gene Chr9:60620272-60646084 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034911
protein coding gene Chr9:60135039-60153943 (+)
A/J MGP_AJ_G0034891
protein coding gene Chr9:58202893-58221795 (+)
AKR/J MGP_AKRJ_G0034821
protein coding gene Chr9:59549738-59570347 (+)
BALB/cJ MGP_BALBcJ_G0034884
protein coding gene Chr9:57917602-57936505 (+)
C3H/HeJ MGP_C3HHeJ_G0034594
protein coding gene Chr9:60032117-60051040 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035403
protein coding gene Chr9:61787214-61808029 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032314
protein coding gene Chr9:57899093-57917872 (+)
CAST/EiJ MGP_CASTEiJ_G0033915
protein coding gene Chr9:60133824-60152474 (+)
CBA/J MGP_CBAJ_G0034565
protein coding gene Chr9:63939703-63958395 (+)
DBA/2J MGP_DBA2J_G0034724
protein coding gene Chr9:58003155-58022726 (+)
FVB/NJ MGP_FVBNJ_G0034666
protein coding gene Chr9:57275355-57301169 (+)
LP/J MGP_LPJ_G0034807
protein coding gene Chr9:60443153-60462030 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034709
protein coding gene Chr9:65410446-65430302 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035425
protein coding gene Chr9:59570390-59590060 (+)
PWK/PhJ MGP_PWKPhJ_G0033619
protein coding gene Chr9:58091945-58110926 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033452
protein coding gene Chr9:59855858-59874505 (+)
WSB/EiJ MGP_WSBEiJ_G0034028
protein coding gene Chr9:59504709-59523404 (+)



Homology
more
  • Human Ortholog
    LARP6, La ribonucleoprotein 6, translational regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LARP6, La ribonucleoprotein 6, translational regulator
  • Synonyms
    ACHN
  • Links
    NCBI Gene ID: 55323
    neXtProt AC: NX_Q9BRS8
    UniProt: Q9BRS8

  • Chr Location
    15q23; chr15:70829130-70854157 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67557 NCBI Gene Model | MGI Sequence Detail 25681 C57BL/6J ±  kb
    transcript NM_026235 RefSeq | MGI Sequence Detail 2308 C57BL/6  
    polypeptide Q8BN59 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143090
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:328890 Zuo S, et al., ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. EMBO J. 2021 Jul 5;:e107403

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory