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Dock6 Gene Detail
Summary
  • Symbol
    Dock6
  • Name
    dedicator of cytokinesis 6
  • Synonyms
    2410095B20Rik, 4931431C02Rik, C330023D02Rik, mKIAA1395
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914789
    NCBI Gene: 319899
Location & Maps
more
  • Sequence Map
    Chr9:21800184-21852635 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52452 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DOCK6, dedicator of cytokinesis 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DOCK6, dedicator of cytokinesis 6
    Orthology source: HomoloGene
  • Synonyms
    AOS2, ZIR1
  • Links
    NCBI Gene ID: 57572
    neXtProt AC: NX_Q96HP0

  • Chr Location
    19p13.2; chr19:11199293-11262501 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DOCK6 associations

Human Disease Mouse Models
       Adams-Oliver Syndrome 2; AOS2   OMIM: 614219
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032198 Ensembl Gene Model | MGI Sequence Detail 52452 C57BL/6J ±  kb
transcript ENSMUST00000034728 Ensembl | MGI Sequence Detail 6556 Not Applicable  
polypeptide ENSMUSP00000034728 Ensembl | MGI Sequence Detail 2111 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    71 from dbSNP Build 137
Protein
Information
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Molecular
Reagents
less
  • All nucleic 63
    cDNA 61
    Primer pair 1
    Other 1

    Microarray probesets 18
Other
Accession IDs
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MGI:1924030, MGI:2442941
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory