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Dock6 Gene Detail
Summary
  • Symbol
    Dock6
  • Name
    dedicator of cytokinesis 6
  • Synonyms
    2410095B20Rik, 4931431C02Rik, C330023D02Rik, mKIAA1395
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914789
    NCBI Gene: 319899
  • Gene Overview
    MyGene.info: DOCK6
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21800180-21852716 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.89 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914789
protein coding gene Chr9:21799860-21852716 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034463
protein coding gene Chr9:19062191-19119569 (-)
A/J MGP_AJ_G0034441
protein coding gene Chr9:18703129-18756509 (-)
AKR/J MGP_AKRJ_G0034368
protein coding gene Chr9:19066017-19121297 (-)
BALB/cJ MGP_BALBcJ_G0034432
protein coding gene Chr9:18584845-18638633 (-)
C3H/HeJ MGP_C3HHeJ_G0034144
protein coding gene Chr9:19364172-19417804 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034953
protein coding gene Chr9:19811693-19870222 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031883
protein coding gene Chr9:17806882-17859615 (-)
CAST/EiJ MGP_CASTEiJ_G0033467
protein coding gene Chr9:19199307-19254751 (-)
CBA/J MGP_CBAJ_G0034117
protein coding gene Chr9:20589545-20649396 (-)
DBA/2J MGP_DBA2J_G0034276
protein coding gene Chr9:18670373-18722904 (-)
FVB/NJ MGP_FVBNJ_G0034219
protein coding gene Chr9:18209719-18268734 (-)
LP/J MGP_LPJ_G0034361
protein coding gene Chr9:19196094-19254144 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034262
protein coding gene Chr9:22166743-22221902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034973
protein coding gene Chr9:19019057-19075950 (-)
PWK/PhJ MGP_PWKPhJ_G0033172
protein coding gene Chr9:18669449-18724713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033007
protein coding gene Chr9:19065864-19122204 (-)
WSB/EiJ MGP_WSBEiJ_G0033582
protein coding gene Chr9:18755592-18808179 (-)



Homology
more
  • Human Ortholog
    DOCK6, dedicator of cytokinesis 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DOCK6, dedicator of cytokinesis 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOS2, ZIR1
  • Links
    NCBI Gene ID: 57572
    neXtProt AC: NX_Q96HP0
    UniProt: Q96HP0

  • Chr Location
    19p13.2; chr19:11199293-11262502 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DOCK6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 319899 NCBI Gene Model | MGI Sequence Detail 52537 C57BL/6J ±  kb
transcript NM_177030 RefSeq | MGI Sequence Detail 6577 C57BL/6  
polypeptide Q8VDR9 UniProt | EBI | MGI Sequence Detail 2080 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 64
    Primer pair 2
    Other 1

    Microarray probesets 18
Other
Accession IDs
less
MGI:1924030, MGI:2442941
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory