Dock6
Gene Detail

Symbol Name ID

Dock6 dedicator of cytokinesis 6 MGI:1914789

Synonyms

2410095B20Rik, 4931431C02Rik, C330023D02Rik, mKIAA1395

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.89 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:21800184-21852635 bp, - strand From Ensembl annotation of GRCm38   52452 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Dock6 ± 2 cM)

Gene Tree: Dock6

Human ortholog

DOCK6 dedicator of cytokinesis 6 NCBI Gene ID 57572
Human Synonyms: AOS2, ZIR1
Human Chr19:11309971-11373157 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human DOCK6 (1)

Alleles and phenotypes

All alleles(106) : Targeted(1) Gene trapped(105)

Gene Ontology (GO) classifications

All GO classifications: (4 annotations)

Process	small GTPase mediated signal transduction
Component	cytoplasm
Function	guanyl-nucleotide exchange factor activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (20)   
Theiler Stages: 15, 17, 19, 20, 21, 28

Assay Type	Results
RNA in situ	13
RT-PCR	8

cDNA source data(61)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) cDNA(61) Primer pair(1) Other(1)
Microarray probesets(18)

Other database links

Ensembl Gene Model	ENSMUSG00000032198 (Evidence)
Entrez Gene	319899 (Evidence)
UniGene	128153
DFCI	TC1579710, TC1587492, TC1603156, TC1605276, TC1623857, TC1714769
DoTS	DT.101312480, DT.101364957, DT.101708985, DT.101734846, DT.110621223, DT.40137551, DT.528778, DT.94137653, DT.97386039
NIA Mouse Gene Index	U030591
Consensus CDS Project	CCDS40555.1
International Mouse Knockout Project Status	Dock6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032198	Ensembl Gene Model | MGI Sequence Detail	52452	C57BL/6J
transcript	ENSMUST00000034728	Ensembl | MGI Sequence Detail	6556	Not Applicable
polypeptide	ENSMUSP00000034728	Ensembl | MGI Sequence Detail	2111	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(61 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026791	Dedicator of cytokinesis
InterPro	IPR026798	Dedicator of cytokinesis C
InterPro	IPR027007	Dedicator of cytokinesis C2 domain
InterPro	IPR021816	Dedicator of cytokinesis C/D, N-terminal
InterPro	IPR010703	Dedicator of cytokinesis C-terminal
Protein Ontology	PR:000006623	dedicator of cytokinesis protein 6

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189271 Shaheen R, et al., Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Am J Hum Genet. 2011 Aug 12;89(2):328-33
All references(35)

Other accession IDs

MGI:1924030, MGI:2442941