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Dock6
Gene Detail
 Symbol
Name
ID
Dock6
dedicator of cytokinesis 6
MGI:1914789
Synonyms 2410095B20Rik, 4931431C02Rik, C330023D02Rik, mKIAA1395
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.89 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:21800184-21852635 bp, - strand
From Ensembl annotation of GRCm38

  52452 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:83291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dock6

Human
homologs
Human Homolog DOCK6, dedicator of cytokinesis 6
NCBI Gene ID 57572
neXtProt AC  NX_Q96HP0
Human Synonyms  AOS2, ZIR1
Human Chr (Location)  19p13.2; chr19:11199293-11262492 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DOCK6
Mutations,
alleles, and
phenotypes
All mutations/alleles(108) : Gene trapped(105) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dock6 interacts with 81 markers (Mir7-1, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process small GTPase mediated signal transduction
Component cytoplasm
Function guanyl-nucleotide exchange factor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (20)   
Theiler Stages: 15, 17, 19, 20, 21, 28
Assay TypeResults
RNA in situ 13
RT-PCR 8
cDNA source data(61)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) cDNA(61) Primer pair(1) Other(1)
Microarray probesets(18)
Other database
links
Ensembl Gene ModelENSMUSG00000032198 (Evidence)
Entrez Gene319899 (Evidence)
UniGene128153
DFCITC1579710, TC1587492, TC1603156, TC1605276, TC1623857, TC1714769
DoTSDT.101312480, DT.101364957, DT.101708985, DT.101734846, DT.110621223, DT.40137551, DT.528778, DT.94137653, DT.97386039
NIA Mouse Gene IndexU030591
Consensus CDS ProjectCCDS40555.1
International Mouse Knockout Project StatusDock6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032198 Ensembl Gene Model | MGI Sequence Detail 52452 C57BL/6J ±  kb
transcript ENSMUST00000034728 Ensembl | MGI Sequence Detail 6556 Not Applicable 
polypeptide ENSMUSP00000034728 Ensembl | MGI Sequence Detail 2111 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026791 Dedicator of cytokinesis
InterPro IPR026798 Dedicator of cytokinesis C
InterPro IPR021816 Dedicator of cytokinesis C/D, N-terminal
InterPro IPR010703 Dedicator of cytokinesis C-terminal
InterPro IPR027007 DHR-1 domain
InterPro IPR027357 DHR-2 domain
Protein Ontology PR:000006623 dedicator of cytokinesis protein 6
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:189271 Shaheen R, et al., Recessive mutations in DOCK6, encoding the guanidine nucleotide exchange factor DOCK6, lead to abnormal actin cytoskeleton organization and Adams-Oliver syndrome. Am J Hum Genet. 2011 Aug 12;89(2):328-33
All references(35)
Other
accession IDs
MGI:1924030, MGI:2442941

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory