About   Help   FAQ
Ttll4 Gene Detail
Summary
  • Symbol
    Ttll4
  • Name
    tubulin tyrosine ligase-like family, member 4
  • Synonyms
    4632407P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914784
    NCBI Gene: 67534
Location & Maps
more
  • Sequence Map
    Chr1:74661745-74703730 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41986 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TTLL4, tubulin tyrosine ligase like 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTLL4, tubulin tyrosine ligase like 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9654
    neXtProt AC: NX_Q14679

  • Chr Location
    2p24.3-p24.1; chr2:218710835-218755416 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    25
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Ttll4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021753 VEGA Gene Model | MGI Sequence Detail 41986 C57BL/6J ±  kb
transcript OTTMUST00000051630 VEGA | MGI Sequence Detail 10019 Not Applicable  
polypeptide OTTMUSP00000024339 VEGA | MGI Sequence Detail 1193 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    135 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016793 tubulin polyglutamylase TTLL4
  • EC
  • InterPro Domains
    IPR027748 Tubulin polyglutamylase TTLL-4
    IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138255
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:231311 Xia P, et al., Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Apr;17(4):369-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory