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Ttll4 Gene Detail
Summary
  • Symbol
    Ttll4
  • Name
    tubulin tyrosine ligase-like family, member 4
  • Synonyms
    4632407P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914784
    NCBI Gene: 67534
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74661645-74701832 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914784
protein coding gene Chr1:74661645-74703730 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016159
protein coding gene Chr1:75269766-75312921 (+)
A/J MGP_AJ_G0016142
protein coding gene Chr1:72640101-72684686 (+)
AKR/J MGP_AKRJ_G0016099
protein coding gene Chr1:74650893-74693330 (+)
BALB/cJ MGP_BALBcJ_G0016097
protein coding gene Chr1:72700274-72743586 (+)
C3H/HeJ MGP_C3HHeJ_G0015928
protein coding gene Chr1:74987427-75029239 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016550
protein coding gene Chr1:78195077-78238230 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014271
protein coding gene Chr1:68208288-68251131 (+)
CAST/EiJ MGP_CASTEiJ_G0015512
protein coding gene Chr1:74310941-74353684 (+)
CBA/J MGP_CBAJ_G0015901
protein coding gene Chr1:80746873-80797922 (+)
DBA/2J MGP_DBA2J_G0016002
protein coding gene Chr1:71964039-72005679 (+)
FVB/NJ MGP_FVBNJ_G0016005
protein coding gene Chr1:71151776-71193884 (+)
LP/J MGP_LPJ_G0016074
protein coding gene Chr1:76381154-76423697 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016025
protein coding gene Chr1:84132040-84176021 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016597
protein coding gene Chr1:74720854-74763767 (+)
PWK/PhJ MGP_PWKPhJ_G0015299
protein coding gene Chr1:71418331-71460784 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015077
protein coding gene Chr1:74088749-74130190 (+)
WSB/EiJ MGP_WSBEiJ_G0015574
protein coding gene Chr1:74524610-74569885 (+)



Homology
more
  • Human Ortholog
    TTLL4, tubulin tyrosine ligase like 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTLL4, tubulin tyrosine ligase like 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9654
    neXtProt AC: NX_Q14679
    UniProt: Q14679

  • Chr Location
    2q35; chr2:218710835-218757484 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8764
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTLL4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67534 NCBI Gene Model | MGI Sequence Detail 40188 C57BL/6J ±  kb
transcript NM_001014974 RefSeq | MGI Sequence Detail 8164 C57BL/6  
polypeptide Q80UG8 UniProt | EBI | MGI Sequence Detail 1193 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138255
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory