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Ttll4 Gene Detail
Summary
  • Symbol
    Ttll4
  • Name
    tubulin tyrosine ligase-like family, member 4
  • Synonyms
    4632407P03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914784
    NCBI Gene: 67534
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:74661745-74703730 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      41986 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TTLL4, tubulin tyrosine ligase like 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TTLL4, tubulin tyrosine ligase like 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9654
    neXtProt AC: NX_Q14679
    UniProt: Q14679

  • Chr Location
    2q35; chr2:218710835-218757484 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 8764
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTLL4
  • Gene Tree
    Ttll4
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    8
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021753 VEGA Gene Model | MGI Sequence Detail 41986 C57BL/6J ±  kb
transcript OTTMUST00000051630 VEGA | MGI Sequence Detail 10019 Not Applicable  
polypeptide OTTMUSP00000024339 VEGA | MGI Sequence Detail 1193 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    135 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138255
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2018
MGI 6.12 		The Jackson Laboratory