Ttll4 MGI Mouse Gene Detail - MGI:1914784 - tubulin tyrosine ligase-like family, member 4

Symbol

Ttll4
Name

tubulin tyrosine ligase-like family, member 4
Synonyms

4632407P03Rik

Feature Type

protein coding gene
IDs

MGI:1914784
NCBI Gene: 67534
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:74700804-74740991 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.54 cM
Mapping Data

2 experiments

SNPs within 2kb

122 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914784	protein coding gene	Chr1:74700804-74742889 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016159	protein coding gene	Chr1:75269766-75312921 (+)
A/J	MGP_AJ_G0016142	protein coding gene	Chr1:72640101-72684686 (+)
AKR/J	MGP_AKRJ_G0016099	protein coding gene	Chr1:74650893-74693330 (+)
BALB/cJ	MGP_BALBcJ_G0016097	protein coding gene	Chr1:72700274-72743586 (+)
C3H/HeJ	MGP_C3HHeJ_G0015928	protein coding gene	Chr1:74987427-75029239 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016550	protein coding gene	Chr1:78195077-78238230 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014271	protein coding gene	Chr1:68208288-68251131 (+)
CAST/EiJ	MGP_CASTEiJ_G0015512	protein coding gene	Chr1:74310941-74353684 (+)
CBA/J	MGP_CBAJ_G0015901	protein coding gene	Chr1:80746873-80797922 (+)
DBA/2J	MGP_DBA2J_G0016002	protein coding gene	Chr1:71964039-72005679 (+)
FVB/NJ	MGP_FVBNJ_G0016005	protein coding gene	Chr1:71151776-71193884 (+)
LP/J	MGP_LPJ_G0016074	protein coding gene	Chr1:76381154-76423697 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016025	protein coding gene	Chr1:84132040-84176021 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016597	protein coding gene	Chr1:74720854-74763767 (+)
PWK/PhJ	MGP_PWKPhJ_G0015299	protein coding gene	Chr1:71418331-71460784 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015077	protein coding gene	Chr1:74088749-74130190 (+)
WSB/EiJ	MGP_WSBEiJ_G0015574	protein coding gene	Chr1:74524610-74569885 (+)

Human Ortholog

TTLL4, tubulin tyrosine ligase like 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TTLL4, tubulin tyrosine ligase like 4
Links

HGNC:28976

NCBI Gene ID: 9654

neXtProt AC: NX_Q14679

UniProt: Q14679
Chr Location

2q35; chr2:218710835-218757484 (+) GRCh38.p7

Alliance of Genome Resources

Ttll4 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TTLL4
Gene Tree

Ttll4

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

19
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Ttll4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ttll4

ZFIN ttll4

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Ttll4 interacts with 408 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

56
RefSeq

6
UniProt

4
CCDS

CCDS15053.1

Ensembl

ENSMUSG00000033257 (Evidence)
NCBI Gene

67534

			Length	Strain/Species	Flank
genomic	67534	NCBI Gene Model \| MGI Sequence Detail	40188	C57BL/6J	± kb
transcript	NM_001014974	RefSeq \| MGI Sequence Detail	8164	C57BL/6
polypeptide	Q80UG8	UniProt \| EBI \| MGI Sequence Detail	1193	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016793 tubulin polyglutamylase TTLL4

(term hierarchy)
EC

6.-.-.-
InterPro Domains

IPR013815 ATP-grasp fold, subdomain 1

IPR027748 Tubulin polyglutamylase TTLL4

IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase

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All nucleic 9

cDNA 9

Microarray probesets 5

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MGI:2138255

Summaries

All 47

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 22
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261

TSS for Ttll4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7442	Chr1:74700709-74700727 (+)	-86 bp
Tssr7443	Chr1:74700792-74700815 (+)	0 bp
Tssr7444	Chr1:74700857-74700872 (+)	61 bp
Tssr7445	Chr1:74700873-74700948 (+)	107 bp
Tssr7446	Chr1:74700953-74700991 (+)	168 bp
Tssr7447	Chr1:74701255-74701275 (+)	461 bp
Tssr7448	Chr1:74705421-74705425 (+)	4,619 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/23/2021 MGI 6.17