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Trim62 Gene Detail
Summary
  • Symbol
    Trim62
  • Name
    tripartite motif-containing 62
  • Synonyms
    6330414G21Rik, Dear1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914775
    NCBI Gene: 67525
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:128777837-128805119 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 62.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914775
 protein coding gene Chr4:128777373-128805121 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028808
 protein coding gene Chr4:130725265-130754750 (+)
A/J MGP_AJ_G0028767
 protein coding gene Chr4:125554292-125582721 (+)
AKR/J MGP_AKRJ_G0028720
 protein coding gene Chr4:129027475-129054910 (+)
BALB/cJ MGP_BALBcJ_G0028790
 protein coding gene Chr4:126132813-126161134 (+)
C3H/HeJ MGP_C3HHeJ_G0028504
 protein coding gene Chr4:129080755-129108617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029232
 protein coding gene Chr4:135682005-135714632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026505
 protein coding gene Chr4:118688664-118715752 (+)
CAST/EiJ MGP_CASTEiJ_G0027937
 protein coding gene Chr4:127248287-127277171 (+)
CBA/J MGP_CBAJ_G0028470
 protein coding gene Chr4:138980013-139007598 (+)
DBA/2J MGP_DBA2J_G0028619
 protein coding gene Chr4:125982994-126010923 (+)
FVB/NJ MGP_FVBNJ_G0028586
 protein coding gene Chr4:124734971-124762708 (+)
LP/J MGP_LPJ_G0028720
 protein coding gene Chr4:131035791-131064955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028612
 protein coding gene Chr4:143900866-143929587 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029270
 protein coding gene Chr4:129396764-129425545 (+)
PWK/PhJ MGP_PWKPhJ_G0027658
 protein coding gene Chr4:122549754-122580197 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027485
 protein coding gene Chr4:125248864-125279175 (+)
WSB/EiJ MGP_WSBEiJ_G0028017
 protein coding gene Chr4:129507314-129535983 (+)



Homology
more
  • Human Ortholog
    TRIM62, tripartite motif containing 62
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM62, tripartite motif containing 62
  • Synonyms
    DEAR1
  • Links
    NCBI Gene ID: 55223
    neXtProt AC: NX_Q9BVG3
    UniProt: Q9BVG3

  • Chr Location
    1p35.1; chr1:33145399-33182059 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous or homozygous for a targeted allele exhibit increased tumorigenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    47
  • cDNA Data
    66
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67525 NCBI Gene Model | MGI Sequence Detail 27283 C57BL/6J ±  kb
    transcript NM_001370756 RefSeq | MGI Sequence Detail 3312 C57BL/6  
    polypeptide Q80V85 UniProt | EBI | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140291
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:265843 Chowdhury R, et al., The Trim family of genes and the retina: Expression and functional characterization. PLoS One. 2018;13(9):e0202867
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory