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Faap20 Gene Detail
Summary
  • Symbol
    Faap20
  • Name
    Fanconi anemia core complex associated protein 20
  • Synonyms
    2610002J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914763
    NCBI Gene: 67513
Location & Maps
more
  • Sequence Map
    Chr4:155249802-155256684 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6883 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FAAP20, Fanconi anemia core complex associated protein 20
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FAAP20, Fanconi anemia core complex associated protein 20
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C1orf86, FP7162
  • Links
    NCBI Gene ID: 199990
    neXtProt AC: NX_Q6NZ36

  • Chr Location
    1p36.33; chr1:2184460-2212720 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Gene trapped
    26
  • Targeted
    2
Homozygous null mice show seminiferous tubule and ovarian follicle degeneration, small litter sizes, and increased sensitivity to DNA crosslinkers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010597 VEGA Gene Model | MGI Sequence Detail 6883 C57BL/6J ±  kb
transcript OTTMUST00000024737 VEGA | MGI Sequence Detail 1479 Not Applicable  
polypeptide OTTMUSP00000030886 VEGA | MGI Sequence Detail 176 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    90 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR031491 FAAP20, FANCA interaction domain
    IPR031490 FAAP20 ubiquitin-binding zinc-finger
Molecular
Reagents
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  • All nucleic 77
    cDNA 77

    Microarray probesets 6
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:224688 Zhang T, et al., Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress. Stem Cells. 2015 Jul;33(7):2320-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory