Faap20 MGI Mouse Gene Detail - MGI:1914763 - Fanconi anemia core complex associated protein 20

Symbol

Faap20
Name

Fanconi anemia core complex associated protein 20
Synonyms

2610002J02Rik

Feature Type

protein coding gene
IDs

MGI:1914763
NCBI Gene: 67513
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:155334259-155341144 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.17 cM
Mapping Data

1 experiment

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914763	protein coding gene	Chr4:155333168-155341144 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029210	protein coding gene	Chr4:159558481-159565355 (+)
A/J	MGP_AJ_G0029175	protein coding gene	Chr4:152861487-152868361 (+)
AKR/J	MGP_AKRJ_G0029123	protein coding gene	Chr4:157023106-157029980 (+)
BALB/cJ	MGP_BALBcJ_G0029191	protein coding gene	Chr4:153332515-153339258 (+)
C3H/HeJ	MGP_C3HHeJ_G0028912	protein coding gene	Chr4:157563027-157569901 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029640	protein coding gene	Chr4:165250466-165257351 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026886	protein coding gene	Chr4:145155590-145162579 (+)
CAST/EiJ	MGP_CASTEiJ_G0028325	protein coding gene	Chr4:154995633-155004873 (+)
CBA/J	MGP_CBAJ_G0028874	protein coding gene	Chr4:170214972-170221840 (+)
DBA/2J	MGP_DBA2J_G0029023	protein coding gene	Chr4:152878924-152886249 (+)
FVB/NJ	MGP_FVBNJ_G0028987	protein coding gene	Chr4:152120376-152127328 (+)
LP/J	MGP_LPJ_G0029113	protein coding gene	Chr4:159480958-159487826 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029014	protein coding gene	Chr4:173066851-173073742 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029672	protein coding gene	Chr4:157623339-157631878 (+)
PWK/PhJ	MGP_PWKPhJ_G0028045	protein coding gene	Chr4:149010518-149017515 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027879	protein coding gene	Chr4:151892450-151899341 (+)
WSB/EiJ	MGP_WSBEiJ_G0028405	protein coding gene	Chr4:157796989-157803863 (+)

Human Ortholog

FAAP20, FA core complex associated protein 20

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAAP20, FA core complex associated protein 20
Synonyms

C1orf86, FP7162
Links

HGNC:26428

NCBI Gene ID: 199990

neXtProt AC: NX_Q6NZ36

UniProt: Q6NZ36
Chr Location

1p36.33; chr1:2184461-2212720 (-) GRCh38

MGI Vertebrate Homology

Faap20 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FAAP20
Gene Tree

Faap20

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

2
Gene trapped

25
Targeted

2
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show seminiferous tubule and ovarian follicle degeneration, small litter sizes, and increased sensitivity to DNA crosslinkers.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

24
cDNA Data

78
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

7
UniProt

3
CCDS

CCDS57317.1, CCDS84835.1

Ensembl

ENSMUSG00000073684 (Evidence)
NCBI Gene

67513

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073684	Ensembl Gene Model \| MGI Sequence Detail	6886	C57BL/6J	± kb
transcript	ENSMUST00000178473	Ensembl \| MGI Sequence Detail	1076	Not Applicable
polypeptide	ENSMUSP00000137116	Ensembl \| MGI Sequence Detail	186	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060153 Fanconi anemia core complex-associated protein 20

(term hierarchy)
InterPro Domains

IPR031491 FAAP20, FANCA interaction domain

IPR031490 FAAP20, zinc finger UBZ2-type

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All nucleic 78

cDNA 78

Microarray probesets 6

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Faap20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40627	Chr4:155334417-155334467 (+)	183 bp
Tssr40628	Chr4:155334545-155334580 (+)	304 bp
Tssr40629	Chr4:155334646-155334658 (+)	393 bp
Tssr40630	Chr4:155334740-155334751 (+)	487 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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