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Faap20 Gene Detail
Summary
  • Symbol
    Faap20
  • Name
    Fanconi anemia core complex associated protein 20
  • Synonyms
    2610002J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914763
    NCBI Gene: 67513
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155249802-155256687 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914763
protein coding gene Chr4:155246756-155256687 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029210
protein coding gene Chr4:159558481-159565355 (+)
A/J MGP_AJ_G0029175
protein coding gene Chr4:152861487-152868361 (+)
AKR/J MGP_AKRJ_G0029123
protein coding gene Chr4:157023106-157029980 (+)
BALB/cJ MGP_BALBcJ_G0029191
protein coding gene Chr4:153332515-153339258 (+)
C3H/HeJ MGP_C3HHeJ_G0028912
protein coding gene Chr4:157563027-157569901 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029640
protein coding gene Chr4:165250466-165257351 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026886
protein coding gene Chr4:145155590-145162579 (+)
CAST/EiJ MGP_CASTEiJ_G0028325
protein coding gene Chr4:154995633-155004873 (+)
CBA/J MGP_CBAJ_G0028874
protein coding gene Chr4:170214972-170221840 (+)
DBA/2J MGP_DBA2J_G0029023
protein coding gene Chr4:152878924-152886249 (+)
FVB/NJ MGP_FVBNJ_G0028987
protein coding gene Chr4:152120376-152127328 (+)
LP/J MGP_LPJ_G0029113
protein coding gene Chr4:159480958-159487826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029014
protein coding gene Chr4:173066851-173073742 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029672
protein coding gene Chr4:157623339-157631878 (+)
PWK/PhJ MGP_PWKPhJ_G0028045
protein coding gene Chr4:149010518-149017515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027879
protein coding gene Chr4:151892450-151899341 (+)
WSB/EiJ MGP_WSBEiJ_G0028405
protein coding gene Chr4:157796989-157803863 (+)



Homology
more
  • Human Ortholog
    FAAP20, FA core complex associated protein 20
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FAAP20, FA core complex associated protein 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf86, FP7162
  • Links
    NCBI Gene ID: 199990
    neXtProt AC: NX_Q6NZ36
    UniProt: Q6NZ36

  • Chr Location
    1p36.33; chr1:2184460-2212720 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show seminiferous tubule and ovarian follicle degeneration, small litter sizes, and increased sensitivity to DNA crosslinkers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073684 Ensembl Gene Model | MGI Sequence Detail 6886 C57BL/6J ±  kb
    transcript ENSMUST00000178473 Ensembl | MGI Sequence Detail 1076 Not Applicable  
    polypeptide ENSMUSP00000137116 Ensembl | MGI Sequence Detail 186 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR031491 FAAP20, FANCA interaction domain
      IPR031490 FAAP20 ubiquitin-binding zinc-finger
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 6
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:224688 Zhang T, et al., Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress. Stem Cells. 2015 Jul;33(7):2320-30

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory