Tvp23b MGI Mouse Gene Detail - MGI:1914760 - trans-golgi network vesicle protein 23B

Symbol

Tvp23b
Name

trans-golgi network vesicle protein 23B
Synonyms

1810036I24Rik, Fam18b

Feature Type

protein coding gene
IDs

MGI:1914760
NCBI Gene: 67510
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:62770281-62786012 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 38.81 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914760	protein coding gene	Chr11:62770281-62807606 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018465	protein coding gene	Chr11:62974021-63009756 (+)
A/J	MGP_AJ_G0018434	protein coding gene	Chr11:60629894-60666360 (+)
AKR/J	MGP_AKRJ_G0018403	protein coding gene	Chr11:62496474-62534106 (+)
BALB/cJ	MGP_BALBcJ_G0018405	protein coding gene	Chr11:60904372-60940681 (+)
C3H/HeJ	MGP_C3HHeJ_G0018218	protein coding gene	Chr11:62469331-62510882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018857	protein coding gene	Chr11:64938314-64976833 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016501	protein coding gene	Chr11:57705703-57739483 (+)
CAST/EiJ	MGP_CASTEiJ_G0017774	protein coding gene	Chr11:62629576-62666735 (+)
CBA/J	MGP_CBAJ_G0018192	protein coding gene	Chr11:67738658-67777010 (+)
DBA/2J	MGP_DBA2J_G0018301	protein coding gene	Chr11:60179265-60214900 (+)
FVB/NJ	MGP_FVBNJ_G0018291	protein coding gene	Chr11:59845923-59881995 (+)
LP/J	MGP_LPJ_G0018373	protein coding gene	Chr11:63501580-63538461 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018315	protein coding gene	Chr11:68719274-68755385 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018898	protein coding gene	Chr11:62654398-62691501 (+)
PWK/PhJ	MGP_PWKPhJ_G0017548	protein coding gene	Chr11:60798827-60835907 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017338	protein coding gene	Chr11:62506073-62541855 (+)
WSB/EiJ	MGP_WSBEiJ_G0017827	protein coding gene	Chr11:62271477-62308074 (+)

Human Ortholog

TVP23B, trans-golgi network vesicle protein 23 homolog B

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TVP23B, trans-golgi network vesicle protein 23 homolog B
Synonyms

CGI-148, FAM18B, FAM18B1, NPD008, YDR084C
Links

HGNC:20399

NCBI Gene ID: 51030

neXtProt AC: NX_Q9NYZ1

UniProt: Q9NYZ1
Chr Location

17p11.2; chr17:18781111-18806714 (+) GRCh38

Human Ortholog

TVP23C, trans-golgi network vesicle protein 23 homolog C
Synonyms

FAM18B2
Links

HGNC:30453

NCBI Gene ID: 201158

neXtProt AC: NX_Q96ET8

UniProt: Q96ET8
Chr Location

17p12; chr17:15502264-15563595 (-) GRCh38

Human Ortholog

TVP23C-CDRT4, TVP23C-CDRT4 readthrough
Synonyms

FAM18B2, FAM18B2-CDRT4, TVP23C
Links

HGNC:42961

NCBI Gene ID: 100533496

neXtProt AC: NX_Q96ET8
Chr Location

17p12; chr17:15436015-15563561 (-) GRCh38

MGI Vertebrate Homology

Tvp23b stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TVP23B, TVP23C, TVP23C-CDRT4
Gene Tree

Tvp23b

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

10
Targeted

3
Genomic Mutations

1 involving Tvp23b
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased susceptibility to induced colitis with decreased Paneth and goblet cell numbers and function.

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All GO Annotations

4
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

1
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tvp23b

ZFIN tvp23b

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All Sequences

45
RefSeq

6
UniProt

1
CCDS

CCDS24834.1

Ensembl

ENSMUSG00000014177 (Evidence)
NCBI Gene

67510

			Length	Strain/Species	Flank
genomic	67510	NCBI Gene Model \| MGI Sequence Detail	15732	C57BL/6J	± kb
transcript	NM_001356521	RefSeq \| MGI Sequence Detail	1928	C57BL/6
polypeptide	Q9D8T4	UniProt \| EBI \| MGI Sequence Detail	205	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029467 Golgi apparatus membrane protein TVP23 homolog C

(term hierarchy)
InterPro Domains

IPR008564 Golgi apparatus membrane protein TVP23-like

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All nucleic 13

Genomic 1

cDNA 12

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:340685 Song R, et al., Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Nat Commun. 2023 Jun 20;14(1):3652

TSS for Tvp23b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102071	Chr11:62770275-62770362 (+)	38 bp
Tssr102072	Chr11:62770386-62770406 (+)	115 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23