Pwp1 MGI Mouse Gene Detail - MGI:1914735 - PWP1 homolog, endonuclein

Symbol

Pwp1
Name

PWP1 homolog, endonuclein
Synonyms

2310058A11Rik, 2610205J09Rik

Feature Type

protein coding gene
IDs

MGI:1914735
NCBI Gene: 103136
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:85707695-85724967 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.73 cM
Mapping Data

2 experiments

SNPs within 2kb

530 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914735	protein coding gene	Chr10:85665358-85724967 (+)
129S1/SvImJ	ENSMUSG00200028315	protein coding gene	Chr10:82159610-82221900 (+)
A/J	ENSMUSG00195021358	protein coding gene	Chr10:82609501-82669112 (+)
AKR/J	ENSMUSG00220020347	protein coding gene	Chr10:82211795-82271405 (+)
BALB/cJ	ENSMUSG00180031315	protein coding gene	Chr10:82612617-82672226 (+)
C3H/HeJ	ENSMUSG00175022394	protein coding gene	Chr10:82488480-82548081 (+)
C57BL/6NJ	ENSMUSG00215023898	protein coding gene	Chr10:82156932-82216542 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015686	protein coding gene	Chr10:79749617-79765656 (+)
CAST/EiJ	ENSTCUG00005033605	protein coding gene	Chr10:81937509-81959296 (+)
CBA/J	ENSMUSG00210032017	protein coding gene	Chr10:82339210-82398814 (+)
DBA/2J	ENSMUSG00185037767	protein coding gene	Chr10:82553276-82612882 (+)
FVB/NJ	ENSMUSG00205016259	protein coding gene	Chr10:82258678-82275943 (+)
JF1/MsJ	ENSUMUG00000008597	protein coding gene	Chr10:83947332-83968864 (+)
LP/J	ENSMUSG00230015793	protein coding gene	Chr10:84445715-84505326 (+)
NOD/ShiLtJ	ENSMUSG00190016374	protein coding gene	Chr10:82595161-82654769 (+)
NZO/HlLtJ	ENSMUSG00225048554	protein coding gene	Chr10:88718418-88778024 (+)
PWK/PhJ	ENSLUMG00010021129	protein coding gene	Chr10:82225196-82246723 (+)
SPRET/EiJ	ENSMSPG00010031297	protein coding gene	Chr10:83638254-83697662 (+)
WSB/EiJ	ENSIUOG00005036821	protein coding gene	Chr10:82320708-82342442 (+)

Human Ortholog

PWP1, PWP1 homolog, endonuclein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PWP1, PWP1 homolog, endonuclein
Synonyms

IEF-SSP-9502, NCLB
Links

HGNC:17015

NCBI Gene ID: 11137

UniProt: Q13610
Chr Location

12q23.3; chr12:107685766-107713462 (+) GRCh38

MGI Vertebrate Homology

Pwp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PWP1
Gene Tree

Pwp1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Pwp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

614
Tissues

11
cDNA Data

131
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pwp1

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All Sequences

58
RefSeq

2
UniProt

6
CCDS

CCDS24092.1

Ensembl

ENSMUSG00000001785 (Evidence)
NCBI Gene

103136

			Length	Strain/Species	Flank
genomic	103136	NCBI Gene Model \| MGI Sequence Detail	17273	C57BL/6J	± kb
transcript	NM_133993	RefSeq \| MGI Sequence Detail	2579	C57BL/6
polypeptide	Q99LL5	UniProt \| EBI \| MGI Sequence Detail	501	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013504 periodic tryptophan protein 1

(term hierarchy)
InterPro Domains

IPR020472 PAC1/LIS1-like, WD-40 repeat

IPR044285 Periodic tryptophan protein 1

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q99LL5 1 site

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All nucleic 132

cDNA 132

Microarray probesets 4

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MGI:1917686, MGI:2143522, MGI:2143712, MGI:2143781, MGI:2143860

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:369172 Wang YF, et al., Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos. Nat Commun. 2025 Jul 1;16(1):5630

TSS for Pwp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94935	Chr10:85707267-85707271 (+)	-426 bp
Tssr94936	Chr10:85707679-85707762 (+)	26 bp
Tssr94937	Chr10:85707768-85707783 (+)	81 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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