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Pwp1 Gene Detail
Summary
  • Symbol
    Pwp1
  • Name
    PWP1 homolog, endonuclein
  • Synonyms
    2310058A11Rik, 2610205J09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914735
    NCBI Gene: 103136
  • Gene Overview
    MyGene.info: PWP1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:85871831-85889103 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 41.73 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914735
protein coding gene Chr10:85829494-85889103 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017602
protein coding gene Chr10:86808943-86826226 (+)
A/J MGP_AJ_G0017582
protein coding gene Chr10:83915567-83932826 (+)
AKR/J MGP_AKRJ_G0017542
protein coding gene Chr10:86253538-86270797 (+)
BALB/cJ MGP_BALBcJ_G0017545
protein coding gene Chr10:84146879-84164240 (+)
C3H/HeJ MGP_C3HHeJ_G0017368
protein coding gene Chr10:86301672-86318931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018002
protein coding gene Chr10:89764187-89782532 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015686
protein coding gene Chr10:79749617-79765656 (+)
CAST/EiJ MGP_CASTEiJ_G0016934
protein coding gene Chr10:86150942-86168138 (+)
CBA/J MGP_CBAJ_G0017337
protein coding gene Chr10:93461742-93479474 (+)
DBA/2J MGP_DBA2J_G0017444
protein coding gene Chr10:83032281-83049548 (+)
FVB/NJ MGP_FVBNJ_G0017437
protein coding gene Chr10:82300775-82318109 (+)
LP/J MGP_LPJ_G0017516
protein coding gene Chr10:87486014-87504278 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017465
protein coding gene Chr10:95116812-95134100 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018039
protein coding gene Chr10:86140487-86158647 (+)
PWK/PhJ MGP_PWKPhJ_G0016715
protein coding gene Chr10:83034605-83052013 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016504
protein coding gene Chr10:84780685-84798777 (+)
WSB/EiJ MGP_WSBEiJ_G0016992
protein coding gene Chr10:86096438-86114452 (+)



Homology
more
  • Human Ortholog
    PWP1, PWP1 homolog, endonuclein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PWP1, PWP1 homolog, endonuclein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IEF-SSP-9502
  • Links
    NCBI Gene ID: 11137
    neXtProt AC: NX_Q13610
    UniProt: Q13610

  • Chr Location
    12q23.3; chr12:107685732-107713162 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5129
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PWP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 103136 NCBI Gene Model | MGI Sequence Detail 17273 C57BL/6J ±  kb
transcript NM_133993 RefSeq | MGI Sequence Detail 2579 C57BL/6  
polypeptide Q99LL5 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 132
    cDNA 132

    Microarray probesets 4
Other
Accession IDs
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MGI:1917686, MGI:2143522, MGI:2143712, MGI:2143781, MGI:2143860
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory