About   Help   FAQ
Abhd5
Gene Detail
Symbol

Name
ID
Abhd5
abhydrolase domain containing 5
MGI:1914719
Synonyms
1300003D03Rik, 2010002J10Rik, CGI-58, IECN5, NCIE2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
73.03 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:122351608-122381524 bp, + strand
From VEGA annotation of GRCm38

  29917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABHD5
Protein SuperFamily: hypothetical protein YDR125c
Gene Tree: Abhd5

Human
homologs
ABHD5, abhydrolase domain containing 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51099
neXtProt AC: NX_Q8WTS1

Human Synonyms: CDS, CGI58, IECN2, NCIE2

Human Chr (Location): 3p21; chr3:43690883-43722725 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ABHD5

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect.
 
Human Diseases Modeled in Mice Using Abhd5 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Abhd5 interacts with 272 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (65)    Tissues (31)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase abhd5    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022749 (Evidence)
Ensembl Gene Model ENSMUSG00000032540 (Evidence)
Entrez Gene 67469 (Evidence)
NIA Mouse Gene Index U011178
EC 2.3.1.51
Consensus CDS Project CCDS23646.1
International Mouse Phenotyping Consortium Status Abhd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022749 VEGA Gene Model | MGI Sequence Detail 29917 C57BL/6J ±  kb
transcript OTTMUST00000054600 VEGA | MGI Sequence Detail 3157 Not Applicable 
polypeptide OTTMUSP00000026078 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR002410 Peptidase S33
Protein Ontology PR:000032150 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:222179 Ou J, et al., Loss of abhd5 promotes colorectal tumor development and progression by inducing aerobic glycolysis and epithelial-mesenchymal transition. Cell Rep. 2014 Dec 11;9(5):1798-811
All references(51)
Disease annotation references (1)
Other
accession IDs
MGI:1917092

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory