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Decr1 Gene Detail
Summary
  • Symbol
    Decr1
  • Name
    2,4-dienoyl CoA reductase 1, mitochondrial
  • Synonyms
    1200012F07Rik, Decr, Nadph
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914710
    NCBI Gene: 67460
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:15917240-15945507 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 6.66 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914710
protein coding gene Chr4:15917240-15945507 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028073
protein coding gene Chr4:12811567-12839751 (-)
A/J MGP_AJ_G0028031
protein coding gene Chr4:12468068-12496351 (-)
AKR/J MGP_AKRJ_G0027996
protein coding gene Chr4:12697465-12725651 (-)
BALB/cJ MGP_BALBcJ_G0028042
protein coding gene Chr4:12407645-12435833 (-)
C3H/HeJ MGP_C3HHeJ_G0027772
protein coding gene Chr4:12807657-12835926 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028485
protein coding gene Chr4:13331342-13359613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025827
protein coding gene Chr4:11655781-11683930 (-)
CAST/EiJ MGP_CASTEiJ_G0027227
protein coding gene Chr4:12647488-12675544 (-)
CBA/J MGP_CBAJ_G0027745
protein coding gene Chr4:13652570-13680837 (-)
DBA/2J MGP_DBA2J_G0027888
protein coding gene Chr4:12301857-12330124 (-)
FVB/NJ MGP_FVBNJ_G0027854
protein coding gene Chr4:12070519-12098790 (-)
LP/J MGP_LPJ_G0027997
protein coding gene Chr4:12849771-12877959 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027887
protein coding gene Chr4:14000086-14028369 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028544
protein coding gene Chr4:12677147-12705418 (-)
PWK/PhJ MGP_PWKPhJ_G0026947
protein coding gene Chr4:12275110-12309214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026776
protein coding gene Chr4:12547793-12575984 (-)
WSB/EiJ MGP_WSBEiJ_G0027304
protein coding gene Chr4:12704166-12733840 (-)



Homology
more
  • Human Ortholog
    DECR1, 2,4-dienoyl-CoA reductase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DECR1, 2,4-dienoyl-CoA reductase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DECR, NADPH, SDR18C1
  • Links
    NCBI Gene ID: 1666
    neXtProt AC: NX_Q16698
    UniProt: Q16698

  • Chr Location
    8q21.3; chr8:90001337-90052004 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68178
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DECR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 images
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to fasting and cold stresses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67460 NCBI Gene Model | MGI Sequence Detail 28268 C57BL/6J ±  kb
    transcript NM_026172 RefSeq | MGI Sequence Detail 2829 Not Specified  
    polypeptide Q9CQ62 UniProt | EBI | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 73
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory