Decr1
Gene Detail

Symbol Name ID

Decr1 2,4-dienoyl CoA reductase 1, mitochondrial MGI:1914710

Synonyms

1200012F07Rik, Decr, Nadph

Feature Type

protein coding gene

Genetic Map

Chromosome 4

6.66 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:15917240-15945507 bp, - strand From VEGA annotation of GRCm38   28268 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68178  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Decr1

Human homologs

Human Homolog		DECR1, 2,4-dienoyl CoA reductase 1, mitochondrial
NCBI Gene ID		1666
neXtProt AC		NX_Q16698
Human Synonyms		DECR, NADPH, SDR18C1
Human Chr (Location)		8q21.3; chr8:91013580-91064227 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DECR1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a null allele exhibit increased sensitivity to fasting and cold stresses.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	fatty acid beta-oxidation, fatty acid metabolic process, ...
Component	cytoplasm, mitochondrion, ...
Function	2,4-dienoyl-CoA reductase (NADPH) activity, NADPH binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (93)    Tissues (93)    Images (1)
Theiler Stages: 22

Assay Type	Results
RNA in situ	93

cDNA source data(71)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) cDNA(71) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000004641 (Evidence)
Ensembl Gene Model	ENSMUSG00000028223 (Evidence)
Entrez Gene	67460 (Evidence)
UniGene	393293
DFCI	TC1576471
DoTS	DT.533407
NIA Mouse Gene Index	U024862
EC	1.3.1.34
Consensus CDS Project	CCDS17985.1
International Mouse Knockout Project Status	Decr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004641	VEGA Gene Model | MGI Sequence Detail	28268	C57BL/6J
transcript	OTTMUST00000010471	VEGA | MGI Sequence Detail	2959	Not Applicable
polypeptide	OTTMUSP00000004962	VEGA | MGI Sequence Detail	335	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(317 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000006373	2,4-dienoyl-CoA reductase, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
All references(35)