About   Help   FAQ
Decr1
Gene Detail
 Symbol
Name
ID
Decr1
2,4-dienoyl CoA reductase 1, mitochondrial
MGI:1914710
Synonyms 1200012F07Rik, Decr, Nadph
Feature Type protein coding gene
Genetic Map
Chromosome 4
6.66 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:15917240-15945507 bp, - strand
From VEGA annotation of GRCm38

  28268 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68178  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Decr1

Human
homologs
Human Homolog DECR1, 2,4-dienoyl CoA reductase 1, mitochondrial
NCBI Gene ID 1666
neXtProt AC  NX_Q16698
Human Synonyms  DECR, NADPH, SDR18C1
Human Chr (Location)  8q21.3; chr8:90001352-90052004 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DECR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased sensitivity to fasting and cold stresses.
 
Interactions
Decr1 interacts with 272 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function 2,4-dienoyl-CoA reductase (NADPH) activity, NADPH binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (93)    Tissues (93)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 93
cDNA source data(72)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(72) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000004641 (Evidence)
Ensembl Gene ModelENSMUSG00000028223 (Evidence)
Entrez Gene67460 (Evidence)
UniGene393293
DFCITC1576471
DoTSDT.533407
NIA Mouse Gene IndexU024862
EC1.3.1.34
Consensus CDS ProjectCCDS17985.1
International Mouse Knockout Project StatusDecr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004641 VEGA Gene Model | MGI Sequence Detail 28268 C57BL/6J ±  kb
transcript OTTMUST00000010471 VEGA | MGI Sequence Detail 2959 Not Applicable 
polypeptide OTTMUSP00000004962 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(349 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000006373 2,4-dienoyl-CoA reductase, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory