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Nvl
Gene Detail
Symbol

Name
ID
Nvl
nuclear VCP-like
MGI:1914709
Synonyms
1200009I24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
84.53 cM, cytoband H4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:181087138-181144204 bp, - strand
From VEGA annotation of GRCm38

  57067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1902  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NVL
Protein SuperFamily: AAA ATPase, Nsf/Cdc48/Vcp types
Gene Tree: Nvl

Human
homologs
NVL, nuclear VCP-like
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4931
neXtProt AC: NX_O15381

Human Chr (Location): 1q41-q42.2; chr1:224227334-224330201 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(24) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nvl interacts with 80 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process biological_process
Component cytoplasm, membrane, ...
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nvl ; ZFIN nvl    NEW 
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000050467 (Evidence)
Ensembl Gene Model ENSMUSG00000026516 (Evidence)
Entrez Gene 67459 (Evidence)
NIA Mouse Gene Index U022149
PDB 2RRE
Consensus CDS Project CCDS15581.1
International Mouse Phenotyping Consortium Status Nvl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050467 VEGA Gene Model | MGI Sequence Detail 57067 C57BL/6J ±  kb
transcript OTTMUST00000128041 VEGA | MGI Sequence Detail 9392 Not Applicable 
polypeptide OTTMUSP00000068953 VEGA | MGI Sequence Detail 855 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(13) UniProt(2)
Polymorphisms
SNPs within 2kb(480 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR003960 ATPase, AAA-type, conserved site
InterPro IPR003959 ATPase, AAA-type, core
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011534 nuclear valosin-containing protein-like
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory