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Map1lc3b Gene Detail
Summary
  • Symbol
    Map1lc3b
  • Name
    microtubule-associated protein 1 light chain 3 beta
  • Synonyms
    1010001C15Rik, Atg8, LC3b, Map1lc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914693
    NCBI Gene: 67443
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:122317177-122325499 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 70.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914693
 protein coding gene Chr8:122317100-122325499 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034213
 protein coding gene Chr8:125108516-125117058 (+)
A/J MGP_AJ_G0034193
 protein coding gene Chr8:119895973-119921482 (+)
AKR/J MGP_AKRJ_G0034120
 protein coding gene Chr8:123418625-123429204 (+)
BALB/cJ MGP_BALBcJ_G0034187
 protein coding gene Chr8:120117753-120126426 (+)
C3H/HeJ MGP_C3HHeJ_G0033898
 protein coding gene Chr8:124122667-124130927 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034707
 protein coding gene Chr8:129257727-129267787 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031649
 protein coding gene Chr8:112751009-112759656 (+)
CAST/EiJ MGP_CASTEiJ_G0033225
 protein coding gene Chr8:124160253-124173568 (+)
CBA/J MGP_CBAJ_G0033871
 protein coding gene Chr8:134022149-134035370 (+)
DBA/2J MGP_DBA2J_G0034027
 protein coding gene Chr8:119101754-119113256 (+)
FVB/NJ MGP_FVBNJ_G0033970
 protein coding gene Chr8:118216762-118225890 (+)
LP/J MGP_LPJ_G0034116
 protein coding gene Chr8:125232255-125241031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034017
 protein coding gene Chr8:136263335-136273999 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034725
 protein coding gene Chr8:123590080-123598340 (+)
PWK/PhJ MGP_PWKPhJ_G0032927
 protein coding gene Chr8:118913026-118922323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032767
 protein coding gene Chr8:122309192-122321804 (+)
WSB/EiJ MGP_WSBEiJ_G0033341
 protein coding gene Chr8:124344216-124354682 (+)



Homology
more
  • Human Ortholog
    MAP1LC3B, microtubule associated protein 1 light chain 3 beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP1LC3B, microtubule associated protein 1 light chain 3 beta
  • Synonyms
    ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
  • Links
    NCBI Gene ID: 81631
    neXtProt AC: NX_Q9GZQ8
    UniProt: Q9GZQ8

  • Chr Location
    16q24.2; chr16:87383953-87404779 (+)  GRCh38
  • Human Ortholog
    MAP1LC3B2, microtubule associated protein 1 light chain 3 beta 2
  • Synonyms
    ATG8G
  • Links
    NCBI Gene ID: 643246
    neXtProt AC: NX_A6NCE7
    UniProt: A6NCE7

  • Chr Location
    12q24.22; chr12:116548105-116576606 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop, breed and behave normally and display a normal life span. In culture, mutant MEFs maintain wild-type levels of fibronectin (FN) protein despite reduced FN synthesis, and show normal induction of autophagosomes under starvation conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    835
  • Tissues
    61
  • cDNA Data
    17
  • Literature Summary
    68
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67443 NCBI Gene Model | MGI Sequence Detail 8323 C57BL/6J ±  kb
    transcript NM_001364358 RefSeq | MGI Sequence Detail 2560 C57BL/6  
    polypeptide Q9CQV6 UniProt | EBI | MGI Sequence Detail 125 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 3
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 68
      Gene Ontology 15
      Phenotypes 28
    • Earliest
      J:65509 Gonzalez-Billault C, et al., Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. Mol Cell Neurosci. 2000 Oct;16(4):408-21
    • Latest
      J:345639 Guo H, et al., ADP-Ribosylation Factor-Interacting Protein 2 Acts as a Novel Regulator of Mitophagy and Autophagy in Podocytes in Diabetic Nephropathy. Antioxidants (Basel). 2024 Jan 8;13(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory