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Map1lc3b Gene Detail
Summary
  • Symbol
    Map1lc3b
  • Name
    microtubule-associated protein 1 light chain 3 beta
  • Synonyms
    1010001C15Rik, Atg8, LC3b, Map1lc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914693
    NCBI Gene: 67443
  • Gene Overview
    MyGene.info: MAP1LC3B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:121590361-121598760 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8400 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.67 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAP1LC3B, microtubule associated protein 1 light chain 3 beta
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MAP1LC3B, microtubule associated protein 1 light chain 3 beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
  • Links
    NCBI Gene ID: 81631
    neXtProt AC: NX_Q9GZQ8
    UniProt: Q9GZQ8

  • Chr Location
    16q24.2; chr16:87392195-87404774 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    33 phenotypes from multigenic genotypes
    155 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop, breed and behave normally and display a normal life span. In culture, mutant MEFs maintain wild-type levels of fibronectin (FN) protein despite reduced FN synthesis, and show normal induction of autophagosomes under starvation conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000043032 VEGA Gene Model | MGI Sequence Detail 8400 C57BL/6J ±  kb
    transcript OTTMUST00000112949 VEGA | MGI Sequence Detail 2633 Not Applicable  
    polypeptide OTTMUSP00000078025 VEGA | MGI Sequence Detail 173 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      85 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • PDB
    • InterPro Domains
      IPR004241 Autophagy protein Atg8 ubiquitin-like
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
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    • All nucleic 19
      cDNA 16
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 31
      Gene Ontology 11
      Phenotypes 155
    • Earliest
      J:65509 Gonzalez-Billault C, et al., Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. Mol Cell Neurosci. 2000 Oct;16(4):408-21
    • Latest
      J:261403 Mayer AL, et al., Enhanced Hepatic PPARalpha Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology. 2018 May 1;159(5):2110-2126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory