Map1lc3b
Gene Detail

Symbol Name ID

Map1lc3b microtubule-associated protein 1 light chain 3 beta MGI:1914693

Synonyms

1010001C15Rik, Atg8, LC3b, Map1lc3

Feature Type

protein coding gene

Genetic Map

Chromosome 8

70.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:121590468-121598047 bp, + strand From NCBI annotation of GRCm38   7580 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: microtubule-associated proteins 1 light chain 3A/3B
Gene Tree: Map1lc3b

Human homologs

Human Homolog		MAP1LC3B, microtubule-associated protein 1 light chain 3 beta
NCBI Gene ID		81631
neXtProt AC		NX_Q9GZQ8
Human Synonyms		ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
Human Chr (Location)		16q24.2; chr16:87425801-87438380 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele develop, breed and behave normally and display a normal life span. In culture, mutant MEFs maintain wild-type levels of fibronectin (FN) protein despite reduced FN synthesis, and show normal induction of autophagosomes under starvation conditions.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	autophagy, positive regulation of protein binding
Component	autophagic vacuole, autophagic vacuole membrane, ...
Function	microtubule binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (50)    Tissues (36)    Images (12)
Theiler Stages: 15, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	28
Western blot	16
RT-PCR	4

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000031812 (Evidence)
Entrez Gene	67443 (Evidence)
NIA Mouse Gene Index	U006446, U009899, U060072, U064787, U125204
Consensus CDS Project	CCDS22726.1
International Mouse Knockout Project Status	Map1lc3b

Sequences

Length	Strain/Species
genomic	67443	NCBI Gene Model | MGI Sequence Detail	7580	C57BL/6J
transcript	NM_026160	RefSeq | MGI Sequence Detail	1712	C57BL/6
polypeptide	Q9CQV6	UniProt | EBI | MGI Sequence Detail	125	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004241	Autophagy protein Atg8 ubiquitin-like
Protein Ontology	PR:000010120	microtubule-associated proteins 1A/1B light chain 3B

Graphical View of Protein Domain Structure

References

(Earliest) J:65509 Gonzalez-Billault C, et al., Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. Mol Cell Neurosci. 2000 Oct;16(4):408-21
(Latest) J:190998 Yang JW, et al., Autophagy appears during the development of the mouse lower first molar. Histochem Cell Biol. 2013 Jan;139(1):109-18
All references(45)