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Map1lc3b
Gene Detail
Symbol

Name
ID
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
MGI:1914693
Synonyms
1010001C15Rik, Atg8, LC3b, Map1lc3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
70.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:121590361-121598760 bp, + strand
From VEGA annotation of GRCm38

  8400 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69359  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: microtubule-associated proteins 1 light chain 3A/3B
Gene Tree: Map1lc3b

Human
homologs
Human Homolog MAP1LC3B, microtubule-associated protein 1 light chain 3 beta
NCBI Gene ID 81631
neXtProt AC  NX_Q9GZQ8
Human Synonyms  ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
Human Chr (Location)  16q24.2; chr16:87389551-87404774 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele develop, breed and behave normally and display a normal life span. In culture, mutant MEFs maintain wild-type levels of fibronectin (FN) protein despite reduced FN synthesis, and show normal induction of autophagosomes under starvation conditions.
 
Interactions
Map1lc3b interacts with 155 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component autophagic vacuole, autophagic vacuole membrane, ...
Function GABA receptor binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (50)    Tissues (37)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 28
Western blot 16
RT-PCR 4
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000043032 (Evidence)
Ensembl Gene ModelENSMUSG00000031812 (Evidence)
Entrez Gene67443 (Evidence)
NIA Mouse Gene IndexU064787, U006446, U060072, U009899, U125204
Consensus CDS ProjectCCDS22726.1
International Mouse Knockout Project StatusMap1lc3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043032 VEGA Gene Model | MGI Sequence Detail 8400 C57BL/6J ±  kb
transcript OTTMUST00000112951 VEGA | MGI Sequence Detail 766 Not Applicable 
polypeptide OTTMUSP00000063260 VEGA | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(2) UniProt(9)
Polymorphisms
SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004241 Autophagy protein Atg8 ubiquitin-like
Protein Ontology PR:000010120 microtubule-associated proteins 1A/1B light chain 3B
References
(Earliest) J:65509 Gonzalez-Billault C, et al., Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. Mol Cell Neurosci. 2000 Oct;16(4):408-21
(Latest) J:207394 Sebti S, et al., BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory