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Xab2
Gene Detail
Symbol

Name
ID
Xab2
XPA binding protein 2
MGI:1914689
Synonyms
0610041O14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
1.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:3608421-3621316 bp, - strand
From VEGA annotation of GRCm38

  12896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5738  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: XAB2
Gene Tree: Xab2

Human
homologs
XAB2, XPA binding protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 56949
neXtProt AC: NX_Q9HCS7

Human Synonyms: HCNP, HCRN, NTC90, SYF1

Human Chr (Location): 19p13.2; chr19:7619525-7629553 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die by the blastocyst stage (E3.5) and some eight-cell stage embryos do not undergo compaction.
 
Interactions
Xab2 interacts with 130 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process blastocyst development, cellular response to DNA damage stimulus, ...
Component catalytic step 1 spliceosome, catalytic step 2 spliceosome, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (11)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
cDNA source data(90)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase xab2 ; ZFIN xab2    NEW 
Molecular
reagents
All nucleic(91) cDNA(91)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034606 (Evidence)
Ensembl Gene Model ENSMUSG00000019470 (Evidence)
Entrez Gene 67439 (Evidence)
UniGene 23739
DFCI TC1573042, TC1614357
NIA Mouse Gene Index U029537
Consensus CDS Project CCDS22065.1
International Mouse Phenotyping Consortium Status Xab2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034606 VEGA Gene Model | MGI Sequence Detail 12896 C57BL/6J ±  kb
transcript OTTMUST00000087802 VEGA | MGI Sequence Detail 2677 Not Applicable 
polypeptide OTTMUSP00000047812 VEGA | MGI Sequence Detail 855 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003107 RNA-processing protein, HAT helix
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR013105 Tetratricopeptide TPR2
Protein Ontology PR:000017470 pre-mRNA-splicing factor SYF1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2142733

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory