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Rfk Gene Detail
Summary
  • Symbol
    Rfk
  • Name
    riboflavin kinase
  • Synonyms
    0610038L10Rik, ATP:riboflavin 5'-phosphotransferase, flavokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914688
    NCBI Gene: 54391
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:17394043-17401349 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 12.82 cM, cytoband B
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914688
protein coding gene Chr19:17394043-17401349 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024964
protein coding gene Chr19:15215004-15222247 (+)
A/J MGP_AJ_G0024941
protein coding gene Chr19:14328237-14335466 (+)
AKR/J MGP_AKRJ_G0024911
protein coding gene Chr19:14900131-14908270 (+)
BALB/cJ MGP_BALBcJ_G0024940
protein coding gene Chr19:14373248-14381498 (+)
C3H/HeJ MGP_C3HHeJ_G0024698
protein coding gene Chr19:14845982-14853269 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025382
protein coding gene Chr19:15779917-15787929 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022801
protein coding gene Chr19:14757419-14764818 (+)
CAST/EiJ MGP_CASTEiJ_G0024166
protein coding gene Chr19:14465203-14472532 (+)
CBA/J MGP_CBAJ_G0024676
protein coding gene Chr19:16326105-16334466 (+)
DBA/2J MGP_DBA2J_G0024808
protein coding gene Chr19:14369116-14376450 (+)
FVB/NJ MGP_FVBNJ_G0024769
protein coding gene Chr19:14287977-14295199 (+)
LP/J MGP_LPJ_G0024892
protein coding gene Chr19:15187379-15194631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024796
protein coding gene Chr19:16216217-16223435 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025437
protein coding gene Chr19:14839327-14846475 (+)
PWK/PhJ MGP_PWKPhJ_G0023915
protein coding gene Chr19:13909592-13916817 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023720
protein coding gene Chr19:14131551-14139050 (+)
WSB/EiJ MGP_WSBEiJ_G0024234
protein coding gene Chr19:14887692-14896134 (+)



Homology
more
  • Human Ortholog
    RFK, riboflavin kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RFK, riboflavin kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIFK
  • Links
    NCBI Gene ID: 55312
    neXtProt AC: NX_Q969G6
    UniProt: Q969G6

  • Chr Location
    9q21.13; chr9:76385517-76394528 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 115690
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: RFK
  • Gene Tree
    Rfk
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die in utero prior to E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54391 NCBI Gene Model | MGI Sequence Detail 7307 C57BL/6J ±  kb
transcript NM_019437 RefSeq | MGI Sequence Detail 2482 C57BL/6  
polypeptide Q8CFV9 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 116
    cDNA 116

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147470
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:250810 Hirano A, et al., FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice. Cell Rep. 2017 Apr 11;19(2):255-266

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory