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Hoga1
Gene Detail
 Symbol
Name
ID
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
MGI:1914682
Synonyms 0610010D20Rik, Dhdpsl, Npl2
Feature Type protein coding gene
Genetic Map
Chromosome 19
35.67 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:42045610-42070953 bp, + strand
From VEGA annotation of GRCm38

  25344 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12130  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dihydrodipicolinate synthase
Gene Tree: Hoga1

Human
homologs
Human Homolog HOGA1, 4-hydroxy-2-oxoglutarate aldolase 1
NCBI Gene ID 112817
neXtProt AC  NX_Q86XE5
Human Synonyms  C10orf65, DHDPS2, DHDPSL, HP3, NPL2
Human Chr (Location)  10q24.2; chr10:97584345-97612802 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human HOGA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hoga1 interacts with 82 markers (Mir27a, Mir27b, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process 4-hydroxyproline catabolic process, glyoxylate catabolic process, ...
Component extracellular vesicular exosome, mitochondrion
Function 4-hydroxy-2-oxoglutarate aldolase activity, catalytic activity, ...
External Resources: FuncBase
Expression
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035806 (Evidence)
Ensembl Gene ModelENSMUSG00000025176 (Evidence)
Entrez Gene67432 (Evidence)
UniGene24196
DFCITC1581960
DoTSDT.490400
NIA Mouse Gene IndexU019463
EC4.1.3.16
Consensus CDS ProjectCCDS29820.1
International Mouse Knockout Project StatusHoga1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035806 VEGA Gene Model | MGI Sequence Detail 25344 C57BL/6J ±  kb
transcript OTTMUST00000091702 VEGA | MGI Sequence Detail 1668 Not Applicable 
polypeptide OTTMUSP00000050533 VEGA | MGI Sequence Detail 321 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(245 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR020625 Dihydrodipicolinate synthetase, active site
InterPro IPR002220 Dihydrodipicolinate synthetase-like
Protein Ontology PR:000032371 probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory