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Ears2 Gene Detail
Summary
  • Symbol
    Ears2
  • Name
    glutamyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    3230401I01Rik, mKIAA1970
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914667
    NCBI Gene: 67417
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:122037213-122067263 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 65.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914667
protein coding gene Chr7:122034162-122067263 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032948
protein coding gene Chr7:126098235-126131213 (-)
A/J MGP_AJ_G0032931
protein coding gene Chr7:122832927-122864903 (-)
AKR/J MGP_AKRJ_G0032863
protein coding gene Chr7:125954528-125986215 (-)
BALB/cJ MGP_BALBcJ_G0032936
protein coding gene Chr7:122522861-122554890 (-)
C3H/HeJ MGP_C3HHeJ_G0032646
protein coding gene Chr7:125883123-125913862 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033442
protein coding gene Chr7:131081021-131111558 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030414
protein coding gene Chr7:124157875-124187817 (-)
CAST/EiJ MGP_CASTEiJ_G0031974
protein coding gene Chr7:117657627-117690657 (-)
CBA/J MGP_CBAJ_G0032619
protein coding gene Chr7:135465510-135511635 (-)
DBA/2J MGP_DBA2J_G0032771
protein coding gene Chr7:120838213-120869209 (-)
FVB/NJ MGP_FVBNJ_G0032724
protein coding gene Chr7:120689119-120718854 (-)
LP/J MGP_LPJ_G0032865
protein coding gene Chr7:127548415-127577902 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032756
protein coding gene Chr7:136857079-136888455 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033462
protein coding gene Chr7:124960707-124993344 (-)
PWK/PhJ MGP_PWKPhJ_G0031682
protein coding gene Chr7:113766329-113797483 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031528
protein coding gene Chr7:111733488-111766516 (-)
WSB/EiJ MGP_WSBEiJ_G0032087
protein coding gene Chr7:125868744-125900760 (-)



Homology
more
  • Human Ortholog
    EARS2, glutamyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EARS2, glutamyl-tRNA synthetase 2, mitochondrial
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COXPD12, gluRS, MSE1
  • Links
    NCBI Gene ID: 124454
    neXtProt AC: NX_Q5JPH6
    UniProt: Q5JPH6

  • Chr Location
    16p12.2; chr16:23522013-23557375 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human EARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030871 Ensembl Gene Model | MGI Sequence Detail 30051 C57BL/6J ±  kb
transcript ENSMUST00000033159 Ensembl | MGI Sequence Detail 2046 Not Applicable  
polypeptide ENSMUSP00000033159 Ensembl | MGI Sequence Detail 523 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000030548 glutamate--tRNA ligase, mitochondrial
  • EC
  • InterPro Domains
    IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding
    IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial
    IPR000924 Glutamyl/glutaminyl-tRNA synthetase
    IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
    IPR033910 Glutamyl-tRNA synthetase
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142095
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory