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Ears2
Gene Detail
 Symbol
Name
ID
Ears2
glutamyl-tRNA synthetase 2 (mitochondrial)(putative)
MGI:1914667
Synonyms 3230401I01Rik, mKIAA1970
Feature Type protein coding gene
Genetic Map
Chromosome 7
65.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:122037213-122067263 bp, - strand
From VEGA annotation of GRCm38

  30051 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6907  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutamate-tRNA ligase
Gene Tree: Ears2

Human
homologs
Human Homolog EARS2, glutamyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID 124454
neXtProt AC  NX_Q5JPH6
Human Synonyms  COXPD12, MSE1
Human Chr (Location)  16p12.2; chr16:23522013-23557375 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EARS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ears2 interacts with 34 markers (Mir99a, Mir99b, Mir139, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process glutamyl-tRNA aminoacylation, translation, ...
Component cytoplasm, mitochondrion
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025467 (Evidence)
Ensembl Gene ModelENSMUSG00000030871 (Evidence)
Entrez Gene67417 (Evidence)
UniGene45171
NIA Mouse Gene IndexU029210
EC6.1.1.17
Consensus CDS ProjectCCDS21807.1
International Mouse Knockout Project StatusEars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025467 VEGA Gene Model | MGI Sequence Detail 30051 C57BL/6J ±  kb
transcript OTTMUST00000062703 VEGA | MGI Sequence Detail 2046 Not Applicable 
polypeptide OTTMUSP00000030963 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(5) UniProt(3)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding
InterPro IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2
InterPro IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
InterPro IPR004527 Glutamate-tRNA ligase, class Ib, bacterial/mitochondrial
InterPro IPR000924 Glutamyl/glutaminyl-tRNA synthetase, class Ib
InterPro IPR020061 Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain
InterPro IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000030548 probable glutamate--tRNA ligase, mitochondrial
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2142095

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory