Kctd16 MGI Mouse Gene Detail - MGI:1914659 - potassium channel tetramerisation domain containing 16

Kctd16 Gene Detail

Symbol

Kctd16
Name

potassium channel tetramerisation domain containing 16
Synonyms

4930434H12Rik, LOC383347

Feature Type

protein coding gene
IDs

MGI:1914659
NCBI Gene: 383348
Alliance

gene page

Sequence Map

Chr18:40258361-40531168 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

272808 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 21.30 cM, cytoband B3
Mapping Data

3 experiments

Human Ortholog

KCTD16, potassium channel tetramerization domain containing 16

Vertebrate Orthologs

10

Human Ortholog

KCTD16, potassium channel tetramerization domain containing 16
Orthology source: HomoloGene, HGNC
Links

HGNC:29244

NCBI Gene ID: 57528

neXtProt AC: NX_Q68DU8

UniProt: Q68DU8
Chr Location

5q31.3; chr5:144170723-144485686 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 44779
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KCTD16
Gene Tree

Kctd16

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available

Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively.

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All GO Annotations

9
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

134
Tissues

17
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kctd16

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Kctd16 interacts with 34 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

22
RefSeq

11
UniProt

1
CCDS

CCDS50264.1
UniGene

76366

Ensembl

ENSMUSG00000051401 (Evidence)
NCBI Gene

383348

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051401	Ensembl Gene Model \| MGI Sequence Detail	272808	C57BL/6J	± kb
transcript	ENSMUST00000091927	Ensembl \| MGI Sequence Detail	1349	Not Applicable
polypeptide	ENSMUSP00000089547	Ensembl \| MGI Sequence Detail	427	Not Applicable

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SNPs within 2kb

1593 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000031813 BTB/POZ domain-containing protein KCTD16

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 13

cDNA 13

Microarray probesets 1

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MGI:2686113

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:249700 Cathomas F, et al., Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16. Behav Brain Res. 2017 Jan 15;317(None):393-400

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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