Kctd16 MGI Mouse Gene Detail - MGI:1914659 - potassium channel tetramerisation domain containing 16

Symbol

Kctd16
Name

potassium channel tetramerisation domain containing 16
Synonyms

2900055J20Rik, 4930434H12Rik, LOC383347

Feature Type

protein coding gene
IDs

MGI:1914659
NCBI Gene: 383348
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr18:40256962-40531630 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 21.30 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

1593 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914659	protein coding gene	Chr18:40256305-40547258 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024372	protein coding gene	Chr18:38823991-39124802 (+)
A/J	MGP_AJ_G0024339	protein coding gene	Chr18:37479446-37763088 (+)
AKR/J	MGP_AKRJ_G0024308	protein coding gene	Chr18:38477439-38766632 (+)
BALB/cJ	MGP_BALBcJ_G0024339	protein coding gene	Chr18:37526964-37815767 (+)
C3H/HeJ	MGP_C3HHeJ_G0024105	protein coding gene	Chr18:38561706-38855451 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024781	protein coding gene	Chr18:40161121-40454417 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022220	protein coding gene	Chr18:37434779-37701563 (+)
CAST/EiJ	MGP_CASTEiJ_G0023580	protein coding gene	Chr18:38526440-38814549 (+)
CBA/J	MGP_CBAJ_G0024075	protein coding gene	Chr18:41377031-41699478 (+)
DBA/2J	MGP_DBA2J_G0024205	protein coding gene	Chr18:37058802-37335531 (+)
FVB/NJ	MGP_FVBNJ_G0024171	protein coding gene	Chr18:36769056-37035278 (+)
LP/J	MGP_LPJ_G0024289	protein coding gene	Chr18:38868020-39156397 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024202	protein coding gene	Chr18:42539430-42841072 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024830	protein coding gene	Chr18:38375480-38673563 (+)
PWK/PhJ	MGP_PWKPhJ_G0023324	protein coding gene	Chr18:37301034-37577934 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023129	protein coding gene	Chr18:38615726-38891573 (+)
WSB/EiJ	MGP_WSBEiJ_G0023643	protein coding gene	Chr18:38261646-38552548 (+)

Human Ortholog

KCTD16, potassium channel tetramerization domain containing 16

Vertebrate Orthologs

10

Human Ortholog

KCTD16, potassium channel tetramerization domain containing 16
Orthology source: HomoloGene, HGNC
Links

HGNC:29244

NCBI Gene ID: 57528

neXtProt AC: NX_Q68DU8

UniProt: Q68DU8
Chr Location

5q31.3; chr5:144170723-144485686 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 44779
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: KCTD16
Gene Tree

Kctd16

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , APF , CvDC
Find Mice (IMSR)

10 strains or lines available

Homozygous knockout leads to reduced extinction or increase of fear memory in cued or contextual conditioning behavior tests, respectively.

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All GO Annotations

12
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

17
cDNA Data

16
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kctd16

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Kctd16 interacts with 92 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

54
RefSeq

9
UniProt

3
CCDS

CCDS50264.1
UniGene

428647, 76366

Ensembl

ENSMUSG00000051401 (Evidence)
NCBI Gene

383348

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051401	Ensembl Gene Model \| MGI Sequence Detail	274669	C57BL/6J	± kb
transcript	ENSMUST00000236889	Ensembl \| MGI Sequence Detail	2767	Not Applicable
polypeptide	ENSMUSP00000158201	Ensembl \| MGI Sequence Detail	427	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031813 BTB/POZ domain-containing protein KCTD16

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR003131 Potassium channel tetramerisation-type BTB domain

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 16

cDNA 16

Microarray probesets 3

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MGI:1920251, MGI:2686113

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:249700 Cathomas F, et al., Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16. Behav Brain Res. 2017 Jan 15;317:393-400

TSS for Kctd16:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150843	Chr18:40256870-40256882 (+)	-86 bp
Tssr150844	Chr18:40256947-40256951 (+)	-13 bp
Tssr150845	Chr18:40256960-40257018 (+)	27 bp
Tssr150846	Chr18:40257031-40257042 (+)	75 bp
Tssr150855	Chr18:40512986-40513003 (+)	256,033 bp
Tssr150856	Chr18:40513024-40513027 (+)	256,064 bp
Tssr150858	Chr18:40530749-40530770 (+)	273,798 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16