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Pdlim7 Gene Detail
Summary
  • Symbol
    Pdlim7
  • Name
    PDZ and LIM domain 7
  • Synonyms
    1110003B01Rik, 2410002J21Rik, Enigma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914649
    NCBI Gene: 67399
  • Gene Overview
    MyGene.info: PDLIM7
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr13:55495795-55513676 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      17882 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PDLIM7, PDZ and LIM domain 7
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PDLIM7, PDZ and LIM domain 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LMP1, LMP3
  • Links
    NCBI Gene ID: 9260
    neXtProt AC: NX_Q9NR12
    UniProt: Q9NR12

  • Chr Location
    5q35.3; chr5:177483394-177497605 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    4 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit heart defects and hemostatic dysfunction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    88
  • Tissues
    70
  • cDNA Data
    96
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032913 VEGA Gene Model | MGI Sequence Detail 17882 C57BL/6J ±  kb
    transcript OTTMUST00000082030 VEGA | MGI Sequence Detail 1756 Not Applicable  
    polypeptide OTTMUSP00000043944 VEGA | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      75 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 96
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1919209, MGI:2145386
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:251155 Urban AE, et al., Pdlim7 Regulates Arf6-Dependent Actin Dynamics and Is Required for Platelet-Mediated Thrombosis in Mice. PLoS One. 2016;11(10):e0164042
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory