Pdlim7 MGI Mouse Gene Detail - MGI:1914649

Symbol

Pdlim7
Name

PDZ and LIM domain 7
Synonyms

1110003B01Rik, 2410002J21Rik, Enigma

Feature Type

protein coding gene
IDs

MGI:1914649
NCBI Gene: 67399
Gene Overview

MyGene.info: PDLIM7
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:55497487-55513473 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

75 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914649	protein coding gene	Chr13:55495795-55513676 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020600	protein coding gene	Chr13:54985278-55003193 (-)
A/J	MGP_AJ_G0020554	protein coding gene	Chr13:52950527-52968468 (-)
AKR/J	MGP_AKRJ_G0020532	protein coding gene	Chr13:54514782-54532657 (-)
BALB/cJ	MGP_BALBcJ_G0020550	protein coding gene	Chr13:53182568-53200803 (-)
C3H/HeJ	MGP_C3HHeJ_G0020349	protein coding gene	Chr13:54327464-54345364 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020984	protein coding gene	Chr13:56641458-56660371 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018566	protein coding gene	Chr13:50888425-50906468 (-)
CAST/EiJ	MGP_CASTEiJ_G0019863	protein coding gene	Chr13:54427449-54448262 (-)
CBA/J	MGP_CBAJ_G0020309	protein coding gene	Chr13:58820332-58838297 (-)
DBA/2J	MGP_DBA2J_G0020432	protein coding gene	Chr13:52501780-52519647 (-)
FVB/NJ	MGP_FVBNJ_G0020411	protein coding gene	Chr13:51971955-51990634 (-)
LP/J	MGP_LPJ_G0020508	protein coding gene	Chr13:55238269-55256087 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020440	protein coding gene	Chr13:58284737-58302614 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021027	protein coding gene	Chr13:54095374-54114250 (-)
PWK/PhJ	MGP_PWKPhJ_G0019619	protein coding gene	Chr13:52527815-52546438 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019446	protein coding gene	Chr13:53022730-53040695 (-)
WSB/EiJ	MGP_WSBEiJ_G0019925	protein coding gene	Chr13:54452530-54473163 (-)

Human Ortholog

PDLIM7, PDZ and LIM domain 7

Vertebrate Orthologs

8

Human Ortholog

PDLIM7, PDZ and LIM domain 7
Orthology source: HomoloGene, HGNC
Synonyms

LMP1, LMP3
Links

HGNC:22958

NCBI Gene ID: 9260

neXtProt AC: NX_Q9NR12

UniProt: Q9NR12
Chr Location

5q35.3; chr5:177483394-177497605 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3980
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: PDLIM7
Gene Tree

Pdlim7

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References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
4 images
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

12
Targeted

1
Genomic Mutations

2 involving Pdlim7
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit heart defects and hemostatic dysfunction.

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All GO Annotations

15
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

88
Tissues

70
cDNA Data

98
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pdlim7

ZFIN pdlim7

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Pdlim7 interacts with 208 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

93
RefSeq

19
UniProt

5
CCDS

CCDS26547.1, CCDS49275.1, CCDS49276.1
UniGene

275648

Ensembl

ENSMUSG00000021493 (Evidence)
NCBI Gene

67399

			Length	Strain/Species	Flank
genomic	67399	NCBI Gene Model \| MGI Sequence Detail	15987	C57BL/6J	± kb
transcript	NM_001114088	RefSeq \| MGI Sequence Detail	2626	C57BL/6
polypeptide	Q3TJD7	UniProt \| EBI \| MGI Sequence Detail	457	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012512 PDZ and LIM domain protein 7

(term hierarchy)
InterPro Domains

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR001781 Zinc finger, LIM-type

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All nucleic 99

cDNA 98

Primer pair 1

Microarray probesets 10

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MGI:1919209, MGI:2145386

Summaries

All 40

Developmental Gene Expression 3

Diseases 1

Gene Ontology 4

Phenotypes 10
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:256956 Brinegar AE, et al., Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. Elife. 2017 Aug 11;6

TSS for Pdlim7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122711	Chr13:55513427-55513443 (-)	38 bp
Tssr122710	Chr13:55512357-55512369 (-)	1,110 bp
Tssr122709	Chr13:55512339-55512352 (-)	1,127 bp
Tssr122708	Chr13:55508299-55508326 (-)	5,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13