Pdlim7 MGI Mouse Gene Detail - MGI:1914649

Pdlim7 Gene Detail

Symbol

Pdlim7
Name

PDZ and LIM domain 7
Synonyms

1110003B01Rik, 2410002J21Rik, Enigma

Feature Type

protein coding gene
IDs

MGI:1914649
NCBI Gene: 67399
Gene Overview

MyGene.info: PDLIM7

Sequence Map

Chr13:55495795-55513676 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

17882 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 30.06 cM, cytoband B2
Mapping Data

3 experiments

Human Ortholog

PDLIM7, PDZ and LIM domain 7

Vertebrate Orthologs

8

Human Ortholog

PDLIM7, PDZ and LIM domain 7
Orthology source: HomoloGene, HGNC
Synonyms

LMP1, LMP3
Links

HGNC:22958

NCBI Gene ID: 9260

neXtProt AC: NX_Q9NR12
Chr Location

5q35.3; chr5:177483394-177497619 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 3980
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: PDLIM7
Gene Tree

Pdlim7

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References

1 with disease annotations

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Phenotype Summary

19 phenotypes from 1 allele in 1 genetic background
4 images
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

12
Targeted

1
Genomic Mutations

2 involving Pdlim7

Mice homozygous for a gene trap allele exhibit heart defects and hemostatic dysfunction.

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All GO Annotations

16
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

27
Tissues

17
cDNA Data

96
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase pdlim7

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Pdlim7 interacts with 208 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

94
RefSeq

19
UniProt

5
CCDS

CCDS26547.1, CCDS49275.1, CCDS49276.1
UniGene

275648

			Length	Strain/Species	Flank
genomic	OTTMUSG00000032913	VEGA Gene Model \| MGI Sequence Detail	17882	C57BL/6J	± kb
transcript	OTTMUST00000082030	VEGA \| MGI Sequence Detail	1756	Not Applicable
polypeptide	OTTMUSP00000043944	VEGA \| MGI Sequence Detail	457	Not Applicable

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SNPs within 2kb

75 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000012512 PDZ and LIM domain protein 7
InterPro Domains

IPR001478 PDZ domain

IPR001781 Zinc finger, LIM-type

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All nucleic 96

cDNA 96

Microarray probesets 10

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MGI:1919209, MGI:2145386

Summaries

All 34

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:209780 Krcmery J, et al., Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction. PLoS One. 2013;8(11):e80809

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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