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Srpr Gene Detail
Summary
  • Symbol
    Srpr
  • Name
    signal recognition particle receptor ('docking protein')
  • Synonyms
    1300011P19Rik, D11Mgi27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914648
    NCBI Gene: 67398
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35211203-35217003 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 20.06 cM, cytoband A5.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914648
protein coding gene Chr9:35200175-35247973 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034531
protein coding gene Chr9:33004768-33052351 (+)
A/J MGP_AJ_G0034509
protein coding gene Chr9:32151409-32196107 (+)
AKR/J MGP_AKRJ_G0034435
protein coding gene Chr9:32874918-32923666 (+)
BALB/cJ MGP_BALBcJ_G0034500
protein coding gene Chr9:32067660-32113005 (+)
C3H/HeJ MGP_C3HHeJ_G0034212
protein coding gene Chr9:33211144-33259759 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035021
protein coding gene Chr9:34116480-34162340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031951
protein coding gene Chr9:30840109-30887555 (+)
CAST/EiJ MGP_CASTEiJ_G0033535
protein coding gene Chr9:33101568-33162015 (+)
CBA/J MGP_CBAJ_G0034186
protein coding gene Chr9:35266938-35316754 (+)
DBA/2J MGP_DBA2J_G0034343
protein coding gene Chr9:32132955-32179248 (+)
FVB/NJ MGP_FVBNJ_G0034286
protein coding gene Chr9:31546934-31593090 (+)
LP/J MGP_LPJ_G0034429
protein coding gene Chr9:33256040-33305259 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034330
protein coding gene Chr9:36840670-36890487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035041
protein coding gene Chr9:32824616-32876505 (+)
PWK/PhJ MGP_PWKPhJ_G0033240
protein coding gene Chr9:32118690-32165592 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033075
protein coding gene Chr9:32974154-32993839 (+)
WSB/EiJ MGP_WSBEiJ_G0033650
protein coding gene Chr9:32593628-32643093 (+)



Homology
more
  • Human Ortholog
    SRPRA, SRP receptor subunit alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRPRA, SRP receptor subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DP, Sralpha, SRPR
  • Links
    NCBI Gene ID: 6734
    neXtProt AC: NX_P08240
    UniProt: P08240

  • Chr Location
    11q24.2; chr11:126255151-126268982 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2364
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRPRA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67398 NCBI Gene Model | MGI Sequence Detail 5801 C57BL/6J ±  kb
transcript NM_026130 RefSeq | MGI Sequence Detail 2934 C57BL/6  
polypeptide Q9DBG7 UniProt | EBI | MGI Sequence Detail 636 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015632 signal recognition particle receptor subunit alpha
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011012 Longin-like domain superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR007222 Signal recognition particle receptor, alpha subunit, N-terminal
    IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain
    IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
    IPR036225 SRP/SRP receptor, N-terminal
Molecular
Reagents
less
  • All nucleic 239
    cDNA 239

    Microarray probesets 5
Other
Accession IDs
less
MGI:2681058
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:197701 Lang S, et al., Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory