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Cxxc5 Gene Detail
Summary
  • Symbol
    Cxxc5
  • Name
    CXXC finger 5
  • Synonyms
    4930415K17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914643
    NCBI Gene: 67393
  • Gene Overview
    MyGene.info: CXXC5
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:35829818-35861687 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      31870 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.26 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CXXC5, CXXC finger protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CXXC5, CXXC finger protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CF5, HSPC195, RINF, WID
  • Links
    NCBI Gene ID: 51523
    neXtProt AC: NX_Q7LFL8
    UniProt: Q7LFL8

  • Chr Location
    5q31.2; chr5:139647299-139683885 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit an increase in bone mass, bone mineral density, osteocyte dendrite formation, and bone formation rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    134
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046668 Ensembl Gene Model | MGI Sequence Detail 31870 C57BL/6J ±  kb
transcript ENSMUST00000060722 Ensembl | MGI Sequence Detail 2271 Not Applicable  
polypeptide ENSMUSP00000054307 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 134
    cDNA 134

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:242004 Ma S, et al., Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017 May 01;214(5):1471-1491
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/15/2018
MGI 6.12 		The Jackson Laboratory