Cxxc5 MGI Mouse Gene Detail - MGI:1914643

Symbol

Cxxc5
Name

CXXC finger 5
Synonyms

4930415K17Rik

Feature Type

protein coding gene
IDs

MGI:1914643
NCBI Gene: 67393
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr18:35962450-35994741 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.26 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

651 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914643	protein coding gene	Chr18:35962432-35994746 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024272	protein coding gene	Chr18:34170888-34202667 (+)
A/J	MGP_AJ_G0024238	protein coding gene	Chr18:32990895-33023597 (+)
AKR/J	MGP_AKRJ_G0024206	protein coding gene	Chr18:33920069-33951612 (+)
BALB/cJ	MGP_BALBcJ_G0024238	protein coding gene	Chr18:33040388-33072360 (+)
C3H/HeJ	MGP_C3HHeJ_G0024005	protein coding gene	Chr18:33953603-33988894 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024679	protein coding gene	Chr18:35392359-35430235 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022119	protein coding gene	Chr18:33086435-33118988 (+)
CAST/EiJ	MGP_CASTEiJ_G0023480	protein coding gene	Chr18:33949801-33982800 (+)
CBA/J	MGP_CBAJ_G0023973	protein coding gene	Chr18:36425617-36457416 (+)
DBA/2J	MGP_DBA2J_G0024105	protein coding gene	Chr18:32619493-32651161 (+)
FVB/NJ	MGP_FVBNJ_G0024072	protein coding gene	Chr18:32312110-32347267 (+)
LP/J	MGP_LPJ_G0024187	protein coding gene	Chr18:34215422-34247025 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024100	protein coding gene	Chr18:37632725-37665591 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024728	protein coding gene	Chr18:33757000-33796001 (+)
PWK/PhJ	MGP_PWKPhJ_G0023224	protein coding gene	Chr18:32851084-32883999 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023031	protein coding gene	Chr18:34019809-34051899 (+)
WSB/EiJ	MGP_WSBEiJ_G0023543	protein coding gene	Chr18:33687558-33719923 (+)

Human Ortholog

CXXC5, CXXC finger protein 5

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXXC5, CXXC finger protein 5
Synonyms

CF5, HSPC195, RINF, WID
Links

HGNC:26943

NCBI Gene ID: 51523

UniProt: Q7LFL8
Chr Location

5q31.2; chr5:139647299-139683882 (+) GRCh38

MGI Vertebrate Homology

Cxxc5 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: CXXC5
Gene Tree

Cxxc5

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
3 images
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

3
Gene trapped

5
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit an increase in bone mass, bone mineral density, osteocyte dendrite formation, and bone formation rate.

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

3
cDNA Data

135
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CXXC5

ZFIN cxxc5a

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All Sequences

65
RefSeq

16
UniProt

6
CCDS

CCDS29150.1

Ensembl

ENSMUSG00000046668 (Evidence)
NCBI Gene

67393

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046668	Ensembl Gene Model \| MGI Sequence Detail	32292	C57BL/6J	± kb
transcript	ENSMUST00000060722	Ensembl \| MGI Sequence Detail	2302	Not Applicable
polypeptide	ENSMUSP00000054307	Ensembl \| MGI Sequence Detail	317	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006076 CXXC-type zinc finger protein 5

(term hierarchy)
InterPro Domains

IPR040388 CXXC-type zinc finger protein CXXC4/CXXC5

IPR002857 Zinc finger, CXXC-type
GlyGen

Q91WA4 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 137

cDNA 135

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 50

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 20
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345030 Ma L, et al., CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis. Cell Commun Signal. 2024 Jan 2;22(1):4

TSS for Cxxc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150566	Chr18:35961851-35961868 (+)	-590 bp
Tssr150567	Chr18:35961906-35961921 (+)	-536 bp
Tssr150568	Chr18:35962783-35962809 (+)	346 bp
Tssr150569	Chr18:35962832-35962848 (+)	390 bp
Tssr150570	Chr18:35962851-35962874 (+)	413 bp
Tssr150571	Chr18:35962881-35962892 (+)	437 bp
Tssr150572	Chr18:35962893-35962904 (+)	449 bp
Tssr150573	Chr18:35963144-35963164 (+)	704 bp
Tssr150574	Chr18:35963232-35963261 (+)	797 bp
Tssr150575	Chr18:35963353-35963416 (+)	935 bp
Tssr150576	Chr18:35964024-35964026 (+)	1,575 bp
Tssr150577	Chr18:35987732-35987768 (+)	25,300 bp
Tssr150578	Chr18:35987770-35987785 (+)	25,328 bp
Tssr150579	Chr18:35987787-35987803 (+)	25,345 bp
Tssr150580	Chr18:35991746-35991758 (+)	29,302 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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