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Cxxc5 Gene Detail
Summary
  • Symbol
    Cxxc5
  • Name
    CXXC finger 5
  • Synonyms
    4930415K17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914643
    NCBI Gene: 67393
  • Gene Overview
    MyGene.info: CXXC5
Location & Maps
more
  • Sequence Map
    Chr18:35829818-35861687 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31870 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.26 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CXXC5, CXXC finger protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CXXC5, CXXC finger protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CF5, HSPC195, RINF, WID
  • Links
    NCBI Gene ID: 51523
    neXtProt AC: NX_Q7LFL8

  • Chr Location
    5q31.2; chr5:139648716-139683882 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    88
  • Gene trapped
    82
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a null allele exhibit an increase in bone mass, bone mineral density, osteocyte dendrite formation, and bone formation rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046668 Ensembl Gene Model | MGI Sequence Detail 31870 C57BL/6J ±  kb
transcript ENSMUST00000060722 Ensembl | MGI Sequence Detail 2271 Not Applicable  
polypeptide ENSMUSP00000054307 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006076 CXXC-type zinc finger protein 5
  • InterPro Domains
    IPR002857 Zinc finger, CXXC-type
Molecular
Reagents
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  • All nucleic 134
    cDNA 134

    Microarray probesets 4
References
more
  • Summaries
    All 34
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227338 Kim MY, et al., CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation. Glia. 2015 Oct 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory