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Cxxc5 Gene Detail
Summary
  • Symbol
    Cxxc5
  • Name
    CXXC finger 5
  • Synonyms
    4930415K17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914643
    NCBI Gene: 67393
  • Gene Overview
    MyGene.info: CXXC5
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35829818-35861687 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.26 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914643
 protein coding gene Chr18:35829356-35861691 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024272
 protein coding gene Chr18:34170888-34202667 (+)
A/J MGP_AJ_G0024238
 protein coding gene Chr18:32990895-33023597 (+)
AKR/J MGP_AKRJ_G0024206
 protein coding gene Chr18:33920069-33951612 (+)
BALB/cJ MGP_BALBcJ_G0024238
 protein coding gene Chr18:33040388-33072360 (+)
C3H/HeJ MGP_C3HHeJ_G0024005
 protein coding gene Chr18:33953603-33988894 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024679
 protein coding gene Chr18:35392359-35430235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022119
 protein coding gene Chr18:33086435-33118988 (+)
CAST/EiJ MGP_CASTEiJ_G0023480
 protein coding gene Chr18:33949801-33982800 (+)
CBA/J MGP_CBAJ_G0023973
 protein coding gene Chr18:36425617-36457416 (+)
DBA/2J MGP_DBA2J_G0024105
 protein coding gene Chr18:32619493-32651161 (+)
FVB/NJ MGP_FVBNJ_G0024072
 protein coding gene Chr18:32312110-32347267 (+)
LP/J MGP_LPJ_G0024187
 protein coding gene Chr18:34215422-34247025 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024100
 protein coding gene Chr18:37632725-37665591 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024728
 protein coding gene Chr18:33757000-33796001 (+)
PWK/PhJ MGP_PWKPhJ_G0023224
 protein coding gene Chr18:32851084-32883999 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023031
 protein coding gene Chr18:34019809-34051899 (+)
WSB/EiJ MGP_WSBEiJ_G0023543
 protein coding gene Chr18:33687558-33719923 (+)



Homology
more
  • Human Ortholog
    CXXC5, CXXC finger protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CXXC5, CXXC finger protein 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CF5, HSPC195, RINF, WID
  • Links
    NCBI Gene ID: 51523
    neXtProt AC: NX_Q7LFL8
    UniProt: Q7LFL8

  • Chr Location
    5q31.2; chr5:139647299-139683885 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    3 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit an increase in bone mass, bone mineral density, osteocyte dendrite formation, and bone formation rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    135
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046668 Ensembl Gene Model | MGI Sequence Detail 31870 C57BL/6J ±  kb
transcript ENSMUST00000060722 Ensembl | MGI Sequence Detail 2271 Not Applicable  
polypeptide ENSMUSP00000054307 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    cDNA 135

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:242004 Ma S, et al., Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017 May 01;214(5):1471-1491
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory