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Bag4 Gene Detail
Summary
  • Symbol
    Bag4
  • Name
    BCL2-associated athanogene 4
  • Synonyms
    2410112I15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914634
    NCBI Gene: 67384
  • Gene Overview
    MyGene.info: BAG4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:25764538-25785287 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20750 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 14.17 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAG4, BCL2 associated athanogene 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BAG4, BCL2 associated athanogene 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAG-4, SODD
  • Links
    NCBI Gene ID: 9530
    neXtProt AC: NX_O95429
    UniProt: O95429

  • Chr Location
    8p11.23; chr8:38176588-38213301 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant animals may show enhanced cytokine response and increased IL-6 production following TNF challenge. Studies on two different alleles of this gene are not in agreement.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060659 VEGA Gene Model | MGI Sequence Detail 20750 C57BL/6J ±  kb
    transcript OTTMUST00000148327 VEGA | MGI Sequence Detail 4876 Not Applicable  
    polypeptide OTTMUSP00000077122 VEGA | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      37 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 5
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:176630 Rahman P, et al., Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton. J Biol Chem. 2011 Aug 26;286(34):29758-70

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory