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Loxhd1 Gene Detail
Summary
  • Symbol
    Loxhd1
  • Name
    lipoxygenase homology domains 1
  • Synonyms
    1700096C21Rik, sba
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914609
    NCBI Gene: 240411
Location & Maps
more
  • Sequence Map
    Chr18:77307750-77442341 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      134592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.20 cM
  • Mapping Data
    1 experiment
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Chemically induced (ENU)
    1
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Loxhd1
  • Incidental Mutations
Mice honozygous for an ENU-induced mutation exhibit hearing loss associated with hair cell and spiral ganglion degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025866 VEGA Gene Model | MGI Sequence Detail 134592 C57BL/6J ±  kb
transcript OTTMUST00000063742 VEGA | MGI Sequence Detail 4680 Not Applicable  
polypeptide OTTMUSP00000031564 VEGA | MGI Sequence Detail 1478 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    986 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000031082 lipoxygenase homology domain-containing protein 1
  • InterPro Domains
    IPR033033 Lipoxygenase homology domain-containing protein 1
    IPR001024 PLAT/LH2 domain
Molecular
Reagents
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  • All nucleic 4
    cDNA 4
Other
Accession IDs
less
MGI:3708146
References
more
  • Summaries
    All 19
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:193334 Xiong W, et al., TMHS is an integral component of the mechanotransduction machinery of cochlear hair cells. Cell. 2012 Dec 7;151(6):1283-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory