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Herc4 Gene Detail
Summary
  • Symbol
    Herc4
  • Name
    hect domain and RLD 4
  • Synonyms
    1700056O17Rik, 4921531D01Rik, 9530080M15Rik, mKIAA1593
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914595
    NCBI Gene: 67345
Location & Maps
more
  • Sequence Map
    Chr10:63243797-63317881 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.56 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 26091
    neXtProt AC: NX_Q5GLZ8

  • Chr Location
    10q21.3; chr10:67921899-68075348 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    67
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Herc4
  • Incidental Mutations
Mice homozygous for a gene-trapped allele display reduced male fertility associated with a high percentage of angulated sperm tails and impaired sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020064 Ensembl Gene Model | MGI Sequence Detail 74085 C57BL/6J ±  kb
transcript ENSMUST00000020258 Ensembl | MGI Sequence Detail 4019 Not Applicable  
polypeptide ENSMUSP00000020258 Ensembl | MGI Sequence Detail 1049 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    290 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000032543 E3 ubiquitin-protein ligase HERC4
  • EC
  • InterPro Domains
    IPR000569 HECT domain
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR000408 Regulator of chromosome condensation, RCC1
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
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MGI:1924839, MGI:1925766
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory