Herc4 MGI Mouse Gene Detail - MGI:1914595

Symbol

Herc4
Name

hect domain and RLD 4
Synonyms

1700056O17Rik, 4921531D01Rik, 9530080M15Rik, mKIAA1593

Feature Type

protein coding gene
IDs

MGI:1914595
NCBI Gene: 67345
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:63079589-63153657 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.56 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

3201 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914595	protein coding gene	Chr10:63079122-63153660 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017314	protein coding gene	Chr10:62755135-62837993 (+)
A/J	MGP_AJ_G0017292	protein coding gene	Chr10:60792486-60868134 (+)
AKR/J	MGP_AKRJ_G0017252	protein coding gene	Chr10:62401247-62482346 (+)
BALB/cJ	MGP_BALBcJ_G0017252	protein coding gene	Chr10:60905543-60979370 (+)
C3H/HeJ	MGP_C3HHeJ_G0017075	protein coding gene	Chr10:62319778-62401782 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017710	protein coding gene	Chr10:65007759-65091388 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015400	protein coding gene	Chr10:57723201-57797493 (+)
CAST/EiJ	MGP_CASTEiJ_G0016646	protein coding gene	Chr10:62382584-62472335 (+)
CBA/J	MGP_CBAJ_G0017047	protein coding gene	Chr10:67481104-67572546 (+)
DBA/2J	MGP_DBA2J_G0017152	protein coding gene	Chr10:60063099-60143098 (+)
FVB/NJ	MGP_FVBNJ_G0017146	protein coding gene	Chr10:59337050-59412606 (+)
LP/J	MGP_LPJ_G0017226	protein coding gene	Chr10:63160193-63241076 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017174	protein coding gene	Chr10:69623607-69711177 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017748	protein coding gene	Chr10:62241655-62318671 (+)
PWK/PhJ	MGP_PWKPhJ_G0016429	protein coding gene	Chr10:59950372-60026424 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016211	protein coding gene	Chr10:61584221-61663255 (+)
WSB/EiJ	MGP_WSBEiJ_G0016710	protein coding gene	Chr10:62197006-62283985 (+)

Human Ortholog

HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
Links

HGNC:24521

NCBI Gene ID: 26091

UniProt: Q5GLZ8
Chr Location

10q21.3; chr10:67921899-68075301 (-) GRCh38

MGI Vertebrate Homology

Herc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HERC4
Gene Tree

Herc4

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

64
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

56
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Herc4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene-trapped allele display reduced male fertility associated with a high percentage of angulated sperm tails and impaired sperm motility.

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All GO Annotations

22
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase herc4

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All Sequences

88
RefSeq

28
UniProt

2
CCDS

CCDS23897.1, CCDS88014.1

Ensembl

ENSMUSG00000020064 (Evidence)
NCBI Gene

67345

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020064	Ensembl Gene Model \| MGI Sequence Detail	74069	C57BL/6J	± kb
transcript	ENSMUST00000219577	Ensembl \| MGI Sequence Detail	3914	Not Applicable
polypeptide	ENSMUSP00000151886	Ensembl \| MGI Sequence Detail	1057	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032543 probable E3 ubiquitin-protein ligase HERC4

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR051625 Diverse Signaling and Regulatory Domain-Containing Protein

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

IPR000408 Regulator of chromosome condensation, RCC1

IPR051709 Ubiquitin ligases and GTPase regulators

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All nucleic 20

Genomic 1

cDNA 19

Microarray probesets 4

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MGI:1924839, MGI:1925766

Summaries

All 49

Gene Ontology 9

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Herc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93750	Chr10:63079539-63079550 (+)	-44 bp
Tssr93751	Chr10:63079564-63079625 (+)	6 bp
Tssr93752	Chr10:63079667-63079743 (+)	116 bp
Tssr93753	Chr10:63079753-63079765 (+)	170 bp
Tssr93754	Chr10:63079781-63079792 (+)	198 bp
Tssr93755	Chr10:63116743-63116755 (+)	37,160 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24