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Herc4 Gene Detail
Summary
  • Symbol
    Herc4
  • Name
    hect domain and RLD 4
  • Synonyms
    1700056O17Rik, 4921531D01Rik, 9530080M15Rik, mKIAA1593
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914595
    NCBI Gene: 67345
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:63243810-63317878 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.56 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914595
protein coding gene Chr10:63243782-63317881 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017314
protein coding gene Chr10:62755135-62837993 (+)
A/J MGP_AJ_G0017292
protein coding gene Chr10:60792486-60868134 (+)
AKR/J MGP_AKRJ_G0017252
protein coding gene Chr10:62401247-62482346 (+)
BALB/cJ MGP_BALBcJ_G0017252
protein coding gene Chr10:60905543-60979370 (+)
C3H/HeJ MGP_C3HHeJ_G0017075
protein coding gene Chr10:62319778-62401782 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017710
protein coding gene Chr10:65007759-65091388 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015400
protein coding gene Chr10:57723201-57797493 (+)
CAST/EiJ MGP_CASTEiJ_G0016646
protein coding gene Chr10:62382584-62472335 (+)
CBA/J MGP_CBAJ_G0017047
protein coding gene Chr10:67481104-67572546 (+)
DBA/2J MGP_DBA2J_G0017152
protein coding gene Chr10:60063099-60143098 (+)
FVB/NJ MGP_FVBNJ_G0017146
protein coding gene Chr10:59337050-59412606 (+)
LP/J MGP_LPJ_G0017226
protein coding gene Chr10:63160193-63241076 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017174
protein coding gene Chr10:69623607-69711177 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017748
protein coding gene Chr10:62241655-62318671 (+)
PWK/PhJ MGP_PWKPhJ_G0016429
protein coding gene Chr10:59950372-60026424 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016211
protein coding gene Chr10:61584221-61663255 (+)
WSB/EiJ MGP_WSBEiJ_G0016710
protein coding gene Chr10:62197006-62283985 (+)



Homology
more
  • Human Ortholog
    HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 26091
    neXtProt AC: NX_Q5GLZ8
    UniProt: Q5GLZ8

  • Chr Location
    10q21.3; chr10:67921899-68075348 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele display reduced male fertility associated with a high percentage of angulated sperm tails and impaired sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020064 Ensembl Gene Model | MGI Sequence Detail 74069 C57BL/6J ±  kb
transcript ENSMUST00000219577 Ensembl | MGI Sequence Detail 3914 Not Applicable  
polypeptide ENSMUSP00000151886 Ensembl | MGI Sequence Detail 1057 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 20
    Genomic 1
    cDNA 19

    Microarray probesets 4
Other
Accession IDs
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MGI:1924839, MGI:1925766
References
more
  • Summaries
    All 40
    Gene Ontology 3
    Phenotypes 18
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/22/2019
MGI 6.14
The Jackson Laboratory