Herc4 Gene Detail

Summary

• Symbol
  Herc4
• Name
  hect domain and RLD 4
• Synonyms
  1700056O17Rik, 4921531D01Rik, 9530080M15Rik, mKIAA1593

• Feature Type
  protein coding gene
• IDs
  MGI:1914595
  NCBI Gene: 67345

Location & Maps

• Sequence Map
  Chr10:63243797-63317881 bp, + strand
• From Ensembl annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    74085 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 32.56 cM, cytoband B4
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4

• Vertebrate Orthologs
  10

• Human Ortholog
  HERC4, HECT and RLD domain containing E3 ubiquitin protein ligase 4
  Orthology source: HomoloGene, HGNC
• Links
  HGNC:24521

  NCBI Gene ID: 26091

  neXtProt AC: NX_Q5GLZ8

  UniProt: Q5GLZ8

  
  
• Chr Location
  10q21.3; chr10:67921899-68075348 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 56715
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: HERC4
• Protein SuperFamily
  HERC protein
• Gene Tree
  Herc4
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 2 alleles in 2 genetic backgrounds
  18 phenotype references
  

• All Mutations and Alleles
  67
• Chemically induced (other)
  1
• Gene trapped
  62
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  2 involving Herc4
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  48 strains or lines available

Mice homozygous for a gene-trapped allele display reduced male fertility associated with a high percentage of angulated sperm tails and impaired sperm motility.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  9
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  15

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase herc4

Interactions

• Herc4 interacts with 120 markers (Mir7-1, Mir10a, Mir15a, ...) View All

Sequences &
Gene Models

• All Sequences
  46
• RefSeq
  20
• UniProt
  2
• CCDS
  CCDS23897.1

• Ensembl
  ENSMUSG00000020064 (Evidence)
• NCBI Gene
  67345

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000020064	Ensembl Gene Model | MGI Sequence Detail	74085	C57BL/6J
transcript	ENSMUST00000020258	Ensembl | MGI Sequence Detail	4019	Not Applicable
polypeptide	ENSMUSP00000020258	Ensembl | MGI Sequence Detail	1049	Not Applicable

Polymorphisms

• SNPs within 2kb
  290 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000032543 E3 ubiquitin-protein ligase HERC4
  (term hierarchy)
• EC
  2.3.2.26
• InterPro Domains
  IPR000569 HECT domain
  IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
  IPR000408 Regulator of chromosome condensation, RCC1

Molecular
Reagents

• All nucleic 15

  cDNA 15

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1924839, MGI:1925766

References

• Summaries
  All 40

  Gene Ontology 4

  Phenotypes 18
• Earliest
  J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42