Rffl MGI Mouse Gene Detail - MGI:1914588 - ring finger and FYVE like domain containing protein

Rffl Gene Detail

Symbol

Rffl
Name

ring finger and FYVE like domain containing protein
Synonyms

1700051E09Rik, 4930516L10Rik, Carp2, Carp-2, fring, rififylin

Feature Type

protein coding gene
IDs

MGI:1914588
NCBI Gene: 67338
Gene Overview

MyGene.info: RFFL

Sequence Map

Chr11:82802449-82846092 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

43644 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 50.25 cM, cytoband B5
Mapping Data

3 experiments

Human Ortholog

RFFL, ring finger and FYVE like domain containing E3 ubiquitin protein ligase

Vertebrate Orthologs

9

Human Ortholog

RFFL, ring finger and FYVE like domain containing E3 ubiquitin protein ligase
Orthology source: HomoloGene, HGNC
Synonyms

CARP2, CARP-2, FRING, RIFIFYLIN, RNF189, RNF34L
Links

HGNC:24821

NCBI Gene ID: 117584

neXtProt AC: NX_Q8WZ73

UniProt: Q8WZ73
Chr Location

17q12; chr17:35009112-35089329 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12116
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: RFFL
Gene Tree

Rffl

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

All Mutations and Alleles

37
Chemically induced (other)

1
Gene trapped

34
Targeted

2
Genomic Mutations

2 involving Rffl
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for an inactivating targeted mutation of this gene are born at the expected Mendelian frequency; they are viable and fertile and exhibit no apparent abnormal phenotype.

less

All GO Annotations

25
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

87
Tissues

63
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

Rffl interacts with 302 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

less

All Sequences

78
RefSeq

20
UniProt

8
CCDS

CCDS25148.1, CCDS25149.1, CCDS48867.1, CCDS48868.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000000906	VEGA Gene Model \| MGI Sequence Detail	43644	C57BL/6J	± kb
transcript	OTTMUST00000001763	VEGA \| MGI Sequence Detail	4973	Not Applicable
polypeptide	OTTMUSP00000000841	VEGA \| MGI Sequence Detail	363	Not Applicable

less

SNPs within 2kb

290 from dbSNP Build 142

less

UniProt

8 Sequences
Protein Ontology

PR:000013910 E3 ubiquitin-protein ligase rififylin

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR003034 SAP domain

IPR011011 Zinc finger, FYVE/PHD-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

less

All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 7

less

MGI:1922384, MGI:2671013

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:190487 Gan X, et al., PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. Nat Cell Biol. 2012 Jul;14(7):686-96

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/12/2017 MGI 6.10