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Stk35 Gene Detail
Summary
  • Symbol
    Stk35
  • Name
    serine/threonine kinase 35
  • Synonyms
    1700054C12Rik, CLIK1, CLP-36 interacting kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914583
    NCBI Gene: 67333
  • Gene Overview
    MyGene.info: STK35
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129800517-129832287 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914583
protein coding gene Chr2:129800517-129832287 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026492
protein coding gene Chr2:133213390-133246960 (+)
A/J MGP_AJ_G0026456
protein coding gene Chr2:127808220-127839990 (+)
AKR/J MGP_AKRJ_G0026431
protein coding gene Chr2:131433251-131467234 (+)
BALB/cJ MGP_BALBcJ_G0026468
protein coding gene Chr2:128088934-128120886 (+)
C3H/HeJ MGP_C3HHeJ_G0026211
protein coding gene Chr2:131958358-131990417 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026913
protein coding gene Chr2:137358125-137395833 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024290
protein coding gene Chr2:122598864-122629925 (+)
CAST/EiJ MGP_CASTEiJ_G0025672
protein coding gene Chr2:132195019-132227916 (+)
CBA/J MGP_CBAJ_G0026191
protein coding gene Chr2:142446062-142478952 (+)
DBA/2J MGP_DBA2J_G0026325
protein coding gene Chr2:127194718-127226295 (+)
FVB/NJ MGP_FVBNJ_G0026289
protein coding gene Chr2:125842353-125874243 (+)
LP/J MGP_LPJ_G0026430
protein coding gene Chr2:133476609-133508532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026309
protein coding gene Chr2:146317703-146349828 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026968
protein coding gene Chr2:131474431-131506327 (+)
PWK/PhJ MGP_PWKPhJ_G0025408
protein coding gene Chr2:126772717-126806632 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025210
protein coding gene Chr2:130595798-130627642 (+)
WSB/EiJ MGP_WSBEiJ_G0025746
protein coding gene Chr2:132401591-132434497 (+)



Homology
more
  • Human Ortholog
    STK35, serine/threonine kinase 35
  • Vertebrate Orthologs
    12
  • Human Ortholog
    STK35, serine/threonine kinase 35
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLIK1, STK35L1
  • Links
    NCBI Gene ID: 140901
    neXtProt AC: NX_Q8TDR2
    UniProt: Q8TDR2

  • Chr Location
    20p13; chr20:2098035-2148555 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15441
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STK35
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal gametogenesis, eye defects and partial lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67333 NCBI Gene Model | MGI Sequence Detail 31771 C57BL/6J ±  kb
    transcript NM_183262 RefSeq | MGI Sequence Detail 6204 C57BL/6  
    polypeptide Q80ZW0 UniProt | EBI | MGI Sequence Detail 539 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 4
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264258 Miyamoto Y, et al., The STK35 locus contributes to normal gametogenesis and encodes a lncRNA responsive to oxidative stress. Biol Open. 2018 Aug 6;7(8)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory