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Mrpl46 Gene Detail
Summary
  • Symbol
    Mrpl46
  • Name
    mitochondrial ribosomal protein L46
  • Synonyms
    3110052F15Rik, LIECG2, P2ECSL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914558
    NCBI Gene: 67308
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78775341-78783089 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 44.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914558
protein coding gene Chr7:78775236-78783531 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032378
protein coding gene Chr7:80606554-80614911 (-)
A/J MGP_AJ_G0032357
protein coding gene Chr7:78771023-78779319 (-)
AKR/J MGP_AKRJ_G0032293
protein coding gene Chr7:80462406-80470700 (-)
BALB/cJ MGP_BALBcJ_G0032369
protein coding gene Chr7:78469208-78477792 (-)
C3H/HeJ MGP_C3HHeJ_G0032082
protein coding gene Chr7:81123424-81132335 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032861
protein coding gene Chr7:83779402-83788786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029869
protein coding gene Chr7:81332778-81341276 (-)
CAST/EiJ MGP_CASTEiJ_G0031410
protein coding gene Chr7:71964525-71972931 (-)
CBA/J MGP_CBAJ_G0032048
protein coding gene Chr7:86542949-86552087 (-)
DBA/2J MGP_DBA2J_G0032203
protein coding gene Chr7:77364030-77373201 (-)
FVB/NJ MGP_FVBNJ_G0032158
protein coding gene Chr7:77262850-77271152 (-)
LP/J MGP_LPJ_G0032284
protein coding gene Chr7:81855021-81863311 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032195
protein coding gene Chr7:86817551-86826719 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032879
protein coding gene Chr7:79899465-79908916 (-)
PWK/PhJ MGP_PWKPhJ_G0031130
protein coding gene Chr7:70506497-70515177 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030971
protein coding gene Chr7:66886031-66894254 (-)
WSB/EiJ MGP_WSBEiJ_G0031528
protein coding gene Chr7:80220083-80229368 (-)



Homology
more
  • Human Ortholog
    MRPL46, mitochondrial ribosomal protein L46
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MRPL46, mitochondrial ribosomal protein L46
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C15orf4, LIECG2, P2ECSL
  • Links
    NCBI Gene ID: 26589
    neXtProt AC: NX_Q9H2W6
    UniProt: Q9H2W6

  • Chr Location
    15q25.3; chr15:88459478-88467402 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6747
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MRPL46
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Mrpl46
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67308 NCBI Gene Model | MGI Sequence Detail 7749 C57BL/6J ±  kb
transcript NM_023331 RefSeq | MGI Sequence Detail 1173 Not Specified  
polypeptide Q9EQI8 UniProt | EBI | MGI Sequence Detail 283 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    cDNA 52

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142340
References
more
  • Summaries
    All 39
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory