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Gpx7
Gene Detail
Symbol

Name
ID
Gpx7
glutathione peroxidase 7
MGI:1914555
Synonyms
3110050F08Rik, GPX6
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:108400390-108406961 bp, - strand
From VEGA annotation of GRCm38

  6572 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128491  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutathione peroxidase
Gene Tree: Gpx7

Human
homologs
Human Homolog GPX7, glutathione peroxidase 7
NCBI Gene ID 2882
neXtProt AC  NX_Q96SL4
Human Synonyms  CL683, GPX6, GPx-7, GSHPx-7, NPGPx
Human Chr (Location)  1p32; chr1:52602371-52609051 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to oxidative stress, premature death, systemic disease and increased tumor incidence.
 
Interactions
Gpx7 interacts with 46 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (457)    Tissues (182)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 457
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008245 (Evidence)
Ensembl Gene ModelENSMUSG00000028597 (Evidence)
Entrez Gene67305 (Evidence)
UniGene20164
DFCITC1580791
DoTSDT.491710
EC1.11.1.9
Consensus CDS ProjectCCDS18450.1
International Mouse Knockout Project StatusGpx7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008245 VEGA Gene Model | MGI Sequence Detail 6572 C57BL/6J ±  kb
transcript OTTMUST00000018751 VEGA | MGI Sequence Detail 1289 Not Applicable 
polypeptide OTTMUSP00000008606 VEGA | MGI Sequence Detail 186 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000889 Glutathione peroxidase
InterPro IPR013376 Glutathione peroxidase Gpx7, putative
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008216 glutathione peroxidase 7
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202430 Bosello-Travain V, et al., Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7. Biochim Biophys Acta. 2013 Jun;1830(6):3846-57
All references(39)
Other
accession IDs
MGI:2140249

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory